Navigation Links
Fewer platelets could be used for some cancer and bone-marrow transplantation patients
Date:3/10/2010

DALLAS March 10, 2010 Physicians may be able to safely lower the platelet dosage in transfusions for cancer and bone-marrow transplant patients without risking increased bleeding, according to new research involving UT Southwestern Medical Center and 28 other medical institutions.

Reducing platelet transfusions, and lowering the threshold on when to administer transfusions could help address frequent shortages in platelet supplies, said Dr. Victor Aquino, associate professor of pediatrics and an author of the study appearing in The New England Journal of Medicine.

Blood platelet shortages are a big problem in blood banking. So the question is: 'Can you use fewer platelets to achieve the same effect, thereby helping to alleviate that problem?'" said Dr. Aquino, also a bone-marrow transplant physician at Children's Medical Center Dallas. "The basic conclusion of the research was that fewer platelets could be used and that would have a societal benefit because, by using less platelets for oncology patients, more platelets would be available to other people who needed them."

Platelet blood cells help control bleeding, so patients with low platelet counts bleed easily. Typical patients with low platelet counts include those with acute myeloid leukemia (a type of bone marrow cancer), aplastic anemia, some congenital diseases and those undergoing chemotherapy treatments. Platelets for this large patient community can be stored only about five days so supplies constantly must be replenished, Dr. Aquino noted.

The mulitcenter study followed 1,272 patients who received at least one transfusion between 2004 and 2007. Patients randomly assigned low, medium (standard) or higher doses all reported similar bleeding and other adverse events. The low dose saved about a third of platelets when compared with the medium dose.

Researchers also found that they could use a lower threshold of platelets per cubic millimeter to trigger the need for transfusions. Many bone marrow transplant patients receive transfusions every other day, while other types of cancer patients may have transfusions every one or two weeks, Dr. Aquino said.

"If the number is too low, then we give them platelets. The threshold we were using was 20,000 per cubic millimeter. But in this study they used 10,000, and the subjects didn't have much bleeding, so one of the things we have learned is that we may be able to give fewer transfusions," Dr. Aquino said. "At some point the patient will become resistant to platelets and so the fewer transfusions you use, the better it can be for the patient."


'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Recession May Mean Fewer Nips & Tucks
2. Fewer Childhood Deaths From Rheumatic Disease
3. Improved air quality linked to fewer pediatric ear infections
4. Even a Small Dietary Reduction in Salt Could Mean Fewer Heart Attacks, Strokes and Deaths
5. Fewer headaches on the horizon thanks to latest guidelines
6. Fewer left-sided colorectal tumors observed after colonoscopies
7. Wider Adult Screening May Mean Fewer Children With Cystic Fibrosis
8. HIV Therapy Linked to Fewer Suicides
9. NVHR: New Data Finding Fewer than 1 in 5 Hepatitis C Patients Receiving Antiviral Therapy is Wake-Up Call for Washington
10. New Pap Test Guidelines: Start Later, Have Fewer
11. Less HRT, Fewer Cases of Possible Breast Cancer Precursor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... 2016 , , , WHEN: ... 2016 , , , , LOCATION: , , , Online, ... , , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global ... Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager ... pharmaceutical industry is witnessing an exceptional era. Several new demand spaces, ...
Breaking Medicine Technology: