Navigation Links
Fewer platelets could be used for some cancer and bone-marrow transplantation patients
Date:3/10/2010

DALLAS March 10, 2010 Physicians may be able to safely lower the platelet dosage in transfusions for cancer and bone-marrow transplant patients without risking increased bleeding, according to new research involving UT Southwestern Medical Center and 28 other medical institutions.

Reducing platelet transfusions, and lowering the threshold on when to administer transfusions could help address frequent shortages in platelet supplies, said Dr. Victor Aquino, associate professor of pediatrics and an author of the study appearing in The New England Journal of Medicine.

Blood platelet shortages are a big problem in blood banking. So the question is: 'Can you use fewer platelets to achieve the same effect, thereby helping to alleviate that problem?'" said Dr. Aquino, also a bone-marrow transplant physician at Children's Medical Center Dallas. "The basic conclusion of the research was that fewer platelets could be used and that would have a societal benefit because, by using less platelets for oncology patients, more platelets would be available to other people who needed them."

Platelet blood cells help control bleeding, so patients with low platelet counts bleed easily. Typical patients with low platelet counts include those with acute myeloid leukemia (a type of bone marrow cancer), aplastic anemia, some congenital diseases and those undergoing chemotherapy treatments. Platelets for this large patient community can be stored only about five days so supplies constantly must be replenished, Dr. Aquino noted.

The mulitcenter study followed 1,272 patients who received at least one transfusion between 2004 and 2007. Patients randomly assigned low, medium (standard) or higher doses all reported similar bleeding and other adverse events. The low dose saved about a third of platelets when compared with the medium dose.

Researchers also found that they could use a lower threshold of platelets per cubic millimeter to trigger the need for transfusions. Many bone marrow transplant patients receive transfusions every other day, while other types of cancer patients may have transfusions every one or two weeks, Dr. Aquino said.

"If the number is too low, then we give them platelets. The threshold we were using was 20,000 per cubic millimeter. But in this study they used 10,000, and the subjects didn't have much bleeding, so one of the things we have learned is that we may be able to give fewer transfusions," Dr. Aquino said. "At some point the patient will become resistant to platelets and so the fewer transfusions you use, the better it can be for the patient."


'/>"/>

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Recession May Mean Fewer Nips & Tucks
2. Fewer Childhood Deaths From Rheumatic Disease
3. Improved air quality linked to fewer pediatric ear infections
4. Even a Small Dietary Reduction in Salt Could Mean Fewer Heart Attacks, Strokes and Deaths
5. Fewer headaches on the horizon thanks to latest guidelines
6. Fewer left-sided colorectal tumors observed after colonoscopies
7. Wider Adult Screening May Mean Fewer Children With Cystic Fibrosis
8. HIV Therapy Linked to Fewer Suicides
9. NVHR: New Data Finding Fewer than 1 in 5 Hepatitis C Patients Receiving Antiviral Therapy is Wake-Up Call for Washington
10. New Pap Test Guidelines: Start Later, Have Fewer
11. Less HRT, Fewer Cases of Possible Breast Cancer Precursor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent review ... as the number one company for hearing aids, ranking it higher ... other brands. ... Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, state-of-the-art, ...
(Date:9/9/2017)... ... ... Monday, September 18 th .The Brain Tumor Foundation (BTF) begins a week-long ... BTF,s Mobile MRI Unit – a 70 Ft. ... brings its nationwide initiative, the Road to Early Detection Sponsor-A-City Campaign to ...
Breaking Medicine Technology: