Navigation Links
Few DNA repair genes maintain association with cancer in field synopsis

Variants of numerous DNA repair genes initially appeared to be statistically significantly associated with cancer risk in epidemiological studies. When the data from individual studies are pooled, however, few DNA repair gene variants appear truly associated with increased cancer risk, according to a field synopsis published in the December 30 online issue of the Journal of the National Cancer Institute.

Because DNA damage is associated with cancer development, researchers hypothesized that genes required for DNA repair may influence risk of cancer. Initial reports supported the idea. A comprehensive review of the data has not been available previously.

In the current study, John P. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, and colleagues identified 241 previously reported associations between gene variants and the risk of cancer. The team pooled the data from 1,087 data sets and reexamined these associations.

Initially 31 of the 241 associations appeared to be statistically significantly associated with cancer risk in the meta-analysis. However, only two remained statistically significant after the researchers adjusted for multiple comparisons. An XRCC1 allele (-77 T>C) and an allele of ERCC2 (codon 751) were associated with lung cancer risk.

"The lack of many signals with strong credibility that emerged from our analysis, despite an enormous amount of work in this area over the years, needs careful consideration," the authors write. "The ability of the candidate gene approach to identify genetic risk factors may have been overestimated. Alternatively, the importance of the DNA repair pathway may have been exaggerated. However, there is increasing recognition that genetic risks of cancer conferred by single variants are almost always very modest. This means that even if the DNA repair pathway is essential for carcinogenesis, extremely large-scale evidence would be necessary to establish with high confidence the presence of specific associations."

In an accompanying editorial, Ajay Yesupriya, of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention in Atlanta, and colleagues describe an international collaboration of researchers called the Human Genome Epidemiology Network (HuGENet) that advocates a concerted approach to conducting meta-analyses and systematic reviews of literature on gene-disease association studies. The paper by Ioannidis and colleagues is the first HuGENet Field Synopsis on cancer susceptibility.

"The identification of reliable genetic associations is fundamental to the translation of genomic research findings to clinical and public health applications," the editorialists write. "By synthesizing research findings and assessing cumulative evidence, field synopses can recognize the most credible genetic associations."


Contact: Caroline McNeil
Journal of the National Cancer Institute

Related medicine news :

1. ETHICON Launches the Latest Innovation in Hernia Repair Platform; PROCEED(TM) Ventral Patch (PVP(TM) Device)
2. Several New 5th Generation iPod Video Repairs Announced Today
3. Scaffold Could One Day Repair Damaged Hearts
4. New Pathways Studied to Repair Nerves
5. Repair and healing of osteoporotic fractures a focus of upcoming IOF World Congress on Osteoporosis
6. Ventral Hernia Repair Market to Grow to Over $800 Million in 2013
7. Stem cell regeneration repairs congenital heart defect
8. Neural Stem Cells May Help Repair Spina Bifida in Utero
9. Drug Given 24 Hours After Stroke Helps Repair Brain Tissue
10. Scripps research team unravels new cellular repair mechanism
11. New Skin Revitalizing Product Uses Naturally Occurring Serum for the Repair of Sun Damaged Skin
Post Your Comments:
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in ... involving adult stem cell therapies to patients with chronic degenerative medical conditions. Now, ... a Registered Trademark (RTM). , Organizations are required to hold a registered trademark ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software helps practice ... an agreement between the practice owner and the patient that automatically manages all ... projections. Click here to learn more. , According to ...
(Date:11/24/2015)... , ... November 24, 2015 , ... New patients who ... a referral for dental implants at her Mississauga, ON practice. Dr. Williams ... in the placement of dental implants. , Missing teeth can lead to a ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and ... signed an agreement for DILON to distribute GE,s Discovery ... the globe. The signing of this distribution agreement will provide ... Molecular Breast Imaging system and is considered an initial ... better healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... 24, 2015 . ... adds Latest Guidebook for Chinese Medical Device ... published in November 2015 to the medical devices ... library at . ... growing global economies with a fifth population in ...
(Date:11/24/2015)... -- Figure 1, a free mobile-first network that enables healthcare ... a new completely redesigned web version that includes uploading. ... work primarily on a desktop, to upload images directly ... user base, Figure 1 is hosting an event during ... (RSNA) Annual Meeting. Joshua Landy ...
Breaking Medicine Technology: