Navigation Links
Fever control using external cooling reduces early mortality in septic shock patients
Date:2/16/2012

Fever control using external cooling in sedated patients with septic shock is safe and decreases vasopressor requirements and early mortality, according to a new study from researchers in France.

"The benefits and risks of fever control in patients with severe sepsis remains a matter of controversy," said lead author Frdrique Schortgen, MD, PhD, of the Henri Mondor Hospital in Crteil, France. "In our study, external cooling to achieve normothermia in patients with septic shock was safe, accelerated hemodynamic stabilization, decreased vasopressor requirements, increased the rate of shock reversal, and decreased early mortality."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the multicenter trial, 200 febrile adults with septic shock from seven participating ICUs, all of whom were receiving vasopressor treatment, mechanical ventilation and sedation, were randomized to external cooling (n = 101) or no external cooling (n = 99). Patients underwent cooling for 48 hours to maintain a core body temperature between 36.5C and 37C. Vasopressors were tapered to maintain a mean arterial pressure target of 65 mmHg or more in both groups.

After two hours of treatment, body temperature was significantly lower in the cooling group. The percentage of patients with a 50 percent vasopressor dose decrease vs. baseline was significantly higher in the cooling group from 12 hours of treatment; this difference was not significant at 48 hours. Shock reversal during the ICU stay was significantly more common in the cooling group, as was day-14 mortality. All comparisons remained significant after adjustment for baseline vasopressor dose and sepsis severity scores.

The study had several limitations. Patients in the cooling group had a lower baseline dose of vasopressors, perhaps indicating lower illness severity, although all other variables associated with outcomes in sepsis were well balanced between the two treatment groups. In addition, the study was not blinded, and life-supporting treatments given before inclusion during the early stage of sepsis were not recorded.

"Although cooling prevented early deaths in our patients, mortality reduction was not significant at ICU or hospital discharge, and we cannot make definitive conclusions on the effects of cooling on mortality from our data" said Dr. Schortgen. "Larger studies are needed to confirm the positive effects of cooling on mortality we observed and to examine whether fever control provides any additional benefits in patients with severe sepsis."


'/>"/>
Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Flightless mosquitoes developed to help control dengue fever
2. Abington Memorial Hospital's Travelers Clinic Can Protect Travelers From The Now Active Yellow Fever
3. The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide
4. Study finds respiratory symptoms more reliable indicator of H1N1, not fever alone
5. Too Soon to Tell Whether Dengue Fever Will Spread in U.S.
6. Pet allergies worsen hay fever symptoms, Queens study finds
7. Kids Fevers May Not Always Need Treatment
8. Shar-Pei Dogs Shed Light on Human Fever Syndromes
9. Firstborn Kids Seem to Have More Food Allergies, Hay Fever
10. Childhood eczema and hay fever leads to adult allergic asthma
11. Kids Eczema, Hay Fever Linked to Allergic Asthma Later
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... May 06, 2016 , ... Online HR/benefits platforms offer a ... the game for traditional brokers and health plans. “ The Rapid Emergence of Online ... from Atlantic Information Services, Inc. (AIS), will offer an accurate picture of online benefits ...
(Date:5/6/2016)... ... ... From the Speaker Podium to the Exhibit Floor at Booth#514, Worldwide Leading Contact Center ... at SpeechTek 2016 Event, taking place May 23-25 at the Omni Shoreham in Washington ... “5 Customer Engagement Strategies to improve Customer Satisfaction in your Contact Center” on May ...
(Date:5/6/2016)... NY (PRWEB) , ... May 06, 2016 , ... The ... & Resort on the north end of the island close to the town famous ... 17th- August 10th 2016. , “We continue to have an amazing experience in ...
(Date:5/6/2016)... ... May 06, 2016 , ... Multiple award winning plumbing company ... over 35 years. Maintaining core values of exceptional customer service, quality work at reasonable ... a leading name in San Diego plumbing, and other services including heating & air ...
(Date:5/6/2016)... ... 2016 , ... Few events in healthcare changed the landscape ... cost despite its potential to wipe out a silent killer, hepatitis C virus. ... called direct-acting antivirals (DAAs)—have created fallout in the courts and state governments. Advocates ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Research and Markets has ... Ischemic Stroke Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Ischemic Stroke epidemiology, Acute Ischemic ...
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Actinic Keratosis Market ... to their offering.       (Logo: ... Keratosis Market and Competitive Landscape Highlights 2016, ... products, Actinic Keratosis epidemiology, Actinic Keratosis market ...
(Date:5/3/2016)... PUNE, India , May 4, 2016 /PRNewswire/ ... report spreads across 154 pages, profiling 09 key ... It is a professional and in-depth study on ... providing a basic overview of the industry including ... Insulin Needles market analysis is provided for the ...
Breaking Medicine Technology: