Navigation Links
Fetal stem cells from placenta may help maternal heart recover from injury
Date:11/14/2011

Researchers from Mount Sinai School of Medicine have discovered the therapeutic benefit of fetal stem cells in helping the maternal heart recover after heart attack or other injury. The research, which marks a significant advancement in cardiac regenerative medicine, was presented today at the American Heart Association's (AHA) Scientific Sessions 2011 in Orlando, Florida, and is also published in the current issue of Circulation Research, a journal of the AHA.

In the first study of its kind, the Mount Sinai researchers found that fetal stem cells from the placenta migrate to the heart of the mother and home to the site where an injury, such as a heart attack, occurred. The stem cells then reprogram themselves as beating heart stem cells to aid in its repair. The scientists also mimicked this reprogramming in vitro, showing that the fetal cells became spontaneously beating heart cells in cell culture, which has broad-reaching implications in treating heart disease.

Previous studies have documented a phenomenon in which half of women with a type of heart failure called peripartum cardiomyopathy saw their condition spontaneously recover in the months following pregnancy. Based on this evidence, the Mount Sinai team wanted to determine whether fetal stem cells played a role in maternal recovery.

They evaluated the hearts of pregnant female mice that underwent mid-gestation heart injury and survived. Using green fluorescent protein in the fetuses to tag the fetal stem cells derived from the placenta, they found that the green fluorescent stem cells homed to the injured hearts of their mothers, grafted onto the damaged tissue, and differentiated into smooth muscle cells, blood vessel cells, or another type of heart cell called cardiomyocytes.

"Our research shows that fetal stem cells play an important role in inducing maternal cardiac repair," said Hina Chaudhry, MD, Director of Cardiovascular Regenerative Medicine at Mount Sina
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Links to Mental Illness Seen in Fetal Brains: Study
2. Fetal Exposure to Magnetic Fields From Appliances, Power Lines May Up Kids Asthma Risk
3. NICHD renews maternal-fetal medicine, neonatal ties with Women & Infants
4. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
5. Fetal electrocardiogram helps in early detection of neonatal acidosis
6. Fetal programming of disease risk to next generation depends on parental gender
7. The TET1 enzyme steers us through fetal development and fights cancer
8. Society for Maternal-Fetal Medicine commends FDA on makena announcement
9. Study finds that electronic fetal heart rate monitoring greatly reduces infant mortality
10. Study finds even with fetal lung maturity, babies delivered prior to 39 weeks are at risk
11. Fetal Surgery Could Boost Outcomes in Severe Spina Bifida
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... and vegetables are often displayed in the popular ... also plenty of high-sugar foods. A new study ... is portrayed in children,s TV programmes as well ... dietary habits and weight status. , Steingerdur Olafsdottir,s ... in the popular Swedish children,s TV show Bolibompa. ...
(Date:4/23/2014)... Washington, April 21, 2014 Five for-profit and ... of $1.25 million in Proof of Concept grants ... ideas into commercial products, the Life Sciences Discovery ... $300,000 Entrepreneur Mentoring Program grant to the Washington ... statewide advisory network to train the next generation ...
(Date:4/23/2014)... Parents and physicians concerned about an increase in ... can breathe a sigh of relief. According to a ... years worth of data from states with and without ... to increased use among adolescents. The study is published ... of Adolescent Health . , "Any time a ...
(Date:4/23/2014)... published in the journal Oncotarget , explored ... appearances or their own DNA signatures within the ... to design effective, targeted treatment strategies. , Firstly ... mutation and either the KRAS or BRAF mutation. ... the EGFR gene mutation have that specific mutation ...
(Date:4/23/2014)... have shown that proliferation of endogenous neural precursor ... neurons and axons. From the perspective of neural ... Yat-sen University in China observed the effects of ... cell proliferation and expression of basic fibroblast growth ... brain on the infarct side. The researchers found ...
Breaking Medicine News(10 mins):Health News:High-calorie and low-nutrient foods in kids' TV 2Health News:LSDF announces commercialization grants and Entrepreneur Mentoring Program 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2Health News:Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment 2
... pills a patient is prescribed to take and how well ... a new study presented recently at the 19th Annual Meeting ... San Diego (April 11-14). The large-scale study looked at patients ... channel blockers (CCBs), and provides more supportive evidence that adherence ...
... some of us gain more weight than others- This ... molecule called BSX, as scientists from the European Molecular ... [DIFE], Potsdam, and the University of Cincinnati report in ... is the molecular link between spontaneous physical activity and ...
... of Leeds have found a mechanism to prevent a ... ,Dr Lezanne Ooi, a postdoctoral researcher in ... progression of cardiac hypertrophy can be halted by increasing ... a significant discovery because whilst the symptoms can be ...
... Indonesia, the country worst hit by bird flu, have ... susceptible to infection, an official warned Wednesday . ... flu control, Bayu Krisnamurthi, also told reporters the human ... to 86.4 percent, as compared with 74.5 percent the ...
... needs of the country, Prime Minister Manmohan Singh will ... (NDC) to discuss disease control and public health . ... implementation of the National Rural Health Mission (NRHM), he ... issues and ensure efficient functioning of public health services, ...
... Network) Foundation has organized a function for honoring of Organ ... ,Organ donation is the most selfless gift that ... India almost twelve hundred transplants of kidneys, heart, liver have ... take place after declaration of brain death by specialists. MOHAN ...
Cached Medicine News:Health News:Molecular Basis of Obesity-Revealing the Unknown Facts 2Health News:Breakthrough for Treatment of Fatal Heart Condition 2Health News:Honoring of Organ Donor Families at Raj Bhavan in Chennai 2
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... RAPIDS, Mich. , Jan. 15, 2014 As health ... the flu virus, select Meijer pharmacies in Michigan ... strep throat to eligible patients, enabling Meijer pharmacists to administer ... strict protocol set by a physician participating in the study. ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... commitments from institutional investors to purchase an aggregate of ... an at-the-market registered direct offering, led by a dedicated ... definitive purchase agreements with these investors pursuant to which ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
Infusion Cannula, 4.0mm....
Subretinal Injection Cannula, Curved; 20g (0.90) x 1" (25mm); Tip Extension: 3mm, 32g (0.23); Angled at 35°....
Subretinal Fluid Cannula, Straight; 20g (0.90) x 1-1/2" (38mm); 12mm Flexible Tubing Extends 6mm Beyond Tip....
Micro Vitreoretinal Cannula; Angled; 20g (0.90) x 1" (25mm); Tip Extension: 3mm, 32g (0.23); Angled at 65°, 1mm from Tip....
Medicine Products: