Navigation Links
Fetal programming of disease risk to next generation depends on parental gender
Date:6/4/2011

Overexposure to stress hormones in the womb can program the potential for adverse health effects in those children and the next generation, but effects vary depending on whether the mother or father transmits them, a new animal study suggests. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston.

"This research sheds light on how babies who are exposed in the womb to excessive levels of stress hormones, known as glucocorticoids, can pass on the health effects to their own children, and how the effects vary between mothers and fathers," said the study's principal investigator, Amanda Drake, MD, PhD, a senior clinical fellow at the University of Edinburgh in Scotland.

Glucocorticoid levels may become raised during pregnancy if, for example, the mother experiences stress or illness or receives glucocorticoid drugs for treatment of illness or premature labor. Excess glucocorticoid exposure of the fetus can reduce birth weight and raise blood pressure later in life in animals and humans, and babies born with low birth weight are at increased risk of diabetes and heart disease in adulthood, Drake said.

"This has led to the concept of fetal programming, suggesting that the environment experienced in the womb can affect development, resulting in an increased risk of later disease. This increased disease risk can be passed to the next generation," Drake said.

Using a rodent model of early life programming, Drake and colleagues studied the effects of glucocorticoid overexposure, with the drug dexamethasone, during the last week of gestation. They studied the effects on the directly exposed offspring and on their offspring. Their prior research showed that the low birth weight induced by prenatal exposure to dexamethasone transmits to a second generation through both male and female rats, according to Drake.

This new research showed that although birth weight is reduced in the offspring of male or female rats that were exposed to dexamethasone during fetal development, this effect was more pronounced in the offspring of male rats exposed to excess glucocorticoids during development in the womb.

Additionally, although birth weight was reduced in the second generation of rats, the genes that were affected differed from those seen in their parents, Drake said. In the first generation, glucocorticoid overexposure in the womb affected genes in the liver of the fetus and in the placenta. This increased the likelihood of the baby rats having a low birth weight and increased their risk of developing diabetes and heart disease in later life, she said.

However, the genes affected in the second generation depended on whether the mother or the father had been exposed to glucocorticoids while developing in the womb, the authors reported. These affected genes that could produce adverse health effects included genes important in growth and the transport of nutrients across the placenta.

Regarding the study, which was funded by the U.K. Medical Research Council, Drake said, "It could help inform future research to find interventions that could prevent diseases such as diabetes and high blood pressure," Drake said.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. The TET1 enzyme steers us through fetal development and fights cancer
2. Society for Maternal-Fetal Medicine commends FDA on makena announcement
3. Study finds that electronic fetal heart rate monitoring greatly reduces infant mortality
4. Study finds even with fetal lung maturity, babies delivered prior to 39 weeks are at risk
5. Fetal Surgery Could Boost Outcomes in Severe Spina Bifida
6. Figuring out fetal alcohol syndrome in fruit flies
7. AIUM announces ultrasound practice accreditation in fetal echocardiography
8. Hurricanes Linked to Raised Fetal Distress Risk
9. Study finds changes in fetal epigenetics throughout pregnancy
10. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
11. Ultrasensitive detector pinpoints big problem in tiny fetal heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... , June 23, 2016  The National ... has joined the health policy research organization as ... Romano , MD, senior vice president and chief ... company,s representative on the NPC Board of Directors. ... pleased that Mallinckrodt has joined us in support ...
Breaking Medicine Technology: