Navigation Links
Fetal programming of disease risk to next generation depends on parental gender
Date:6/4/2011

Overexposure to stress hormones in the womb can program the potential for adverse health effects in those children and the next generation, but effects vary depending on whether the mother or father transmits them, a new animal study suggests. The results will be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston.

"This research sheds light on how babies who are exposed in the womb to excessive levels of stress hormones, known as glucocorticoids, can pass on the health effects to their own children, and how the effects vary between mothers and fathers," said the study's principal investigator, Amanda Drake, MD, PhD, a senior clinical fellow at the University of Edinburgh in Scotland.

Glucocorticoid levels may become raised during pregnancy if, for example, the mother experiences stress or illness or receives glucocorticoid drugs for treatment of illness or premature labor. Excess glucocorticoid exposure of the fetus can reduce birth weight and raise blood pressure later in life in animals and humans, and babies born with low birth weight are at increased risk of diabetes and heart disease in adulthood, Drake said.

"This has led to the concept of fetal programming, suggesting that the environment experienced in the womb can affect development, resulting in an increased risk of later disease. This increased disease risk can be passed to the next generation," Drake said.

Using a rodent model of early life programming, Drake and colleagues studied the effects of glucocorticoid overexposure, with the drug dexamethasone, during the last week of gestation. They studied the effects on the directly exposed offspring and on their offspring. Their prior research showed that the low birth weight induced by prenatal exposure to dexamethasone transmits to a second generation through both male and female rats, according to Drake.

This new research showed that although birth weight is reduced in the offspring of male or female rats that were exposed to dexamethasone during fetal development, this effect was more pronounced in the offspring of male rats exposed to excess glucocorticoids during development in the womb.

Additionally, although birth weight was reduced in the second generation of rats, the genes that were affected differed from those seen in their parents, Drake said. In the first generation, glucocorticoid overexposure in the womb affected genes in the liver of the fetus and in the placenta. This increased the likelihood of the baby rats having a low birth weight and increased their risk of developing diabetes and heart disease in later life, she said.

However, the genes affected in the second generation depended on whether the mother or the father had been exposed to glucocorticoids while developing in the womb, the authors reported. These affected genes that could produce adverse health effects included genes important in growth and the transport of nutrients across the placenta.

Regarding the study, which was funded by the U.K. Medical Research Council, Drake said, "It could help inform future research to find interventions that could prevent diseases such as diabetes and high blood pressure," Drake said.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. The TET1 enzyme steers us through fetal development and fights cancer
2. Society for Maternal-Fetal Medicine commends FDA on makena announcement
3. Study finds that electronic fetal heart rate monitoring greatly reduces infant mortality
4. Study finds even with fetal lung maturity, babies delivered prior to 39 weeks are at risk
5. Fetal Surgery Could Boost Outcomes in Severe Spina Bifida
6. Figuring out fetal alcohol syndrome in fruit flies
7. AIUM announces ultrasound practice accreditation in fetal echocardiography
8. Hurricanes Linked to Raised Fetal Distress Risk
9. Study finds changes in fetal epigenetics throughout pregnancy
10. Fetal alcohol spectrum disorder linked to high prevalence of epilepsy, Queens study
11. Ultrasensitive detector pinpoints big problem in tiny fetal heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... SAN LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast ... purpose of this dance is to provide a night of fun for teens with and ... to help everyone feel welcomed and included at the event. The dance will take place ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Basketball is a ... integral part of the Peety PoppersTM series, sign language translation is featured in the ... health and wellness in Peety PoppersTM lessons has a sign language translator to teach ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Dignity Health named ... Hospital Emergency Room –Mesa. The new facility is licensed under Dignity Health ... “Dr. Bingham is an excellent leader and will ensure our new freestanding emergency room ...
(Date:2/11/2016)... CA (PRWEB) , ... February 11, 2016 , ... According ... System, a product marketed as a weight loss dietary supplement, is being recalled due ... group Beverly Hills Physicians, because there is not a single supplement on the market ...
(Date:2/11/2016)... ... 2016 , ... Registered nurses, licensed practical nurses and nursing aides who treat ... Act, Time to Heal” on Thursday, February 25 from 9:00 to 11:00 a.m. at ... Chedda, president of ANSA Consultants, who will discuss clinical best practices throughout the continuum ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 Exactus Pharmacy ... providing high-quality specialty pharmacy care for those suffering ... it has achieved full Specialty Pharmacy Accreditation from ... dedicated to promoting health care quality through accreditation, ... --> The URAC accreditation process demonstrates ...
(Date:2/11/2016)... 11, 2016  M3 Biotechnology Inc., spurred by a major "team investment" by Bruce Montgomery ... completed an oversubscribed Series A-Round, according to CEO Leen Kawas , PhD. ... ... ... Kawas said ...
(Date:2/11/2016)... Feb. 11, 2016 SI-BONE, Inc., a ... the iFuse Implant System, a minimally invasive surgical ... of the sacroiliac (SI) joint, announced the publication ... of MIS SI joint fusion for patients suffering ... sacroiliitis or SI joint disruption.  In the first ...
Breaking Medicine Technology: