Navigation Links
Fetal exposure to tributyltin linked to obesity

Irvine, Calif. (Corrected version) Exposing pregnant mice to low doses of the chemical tributyltin (TBT) which was used in marine antifouling paints and is used as an antifungal agent in some paints, certain plastics and a variety of consumer products can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT at low concentrations, similar to those found in the environment and in humans, researchers observed increased body fat, liver fat and fat-specific gene expression in liver and stem cells in mouse "children," "grandchildren" and "great-grandchildren." The "children" were exposed as embryos, while the "grandchildren" may have been exposed as germ cells within the "children." The "great-grandchildren" had never been exposed to TBT. Such effects without exposure are termed transgenerational and thought to be permanently transmitted to future generations.

These findings demonstrate that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects on fat accumulation, gene expression and stem cell programming without further exposure, said study leader Professor Bruce Blumberg with the UC Irvine Departments of Developmental & Cell Biology, Pharmaceutical Sciences and Biomedical Engineering.

The study appeared online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT and related organotins can occur in a variety of ways. TBT contaminates particles derived from such products as shower curtains, vinyl flooring, carpet fibers, polyurethane foams, mold-resistant paints and other consumer products, where it is used as an antifungal agent. As a result, noteworthy levels of TBT have been reported in house dust, which may be particularly relevant for young children who can spend significant time on floors and carpets. Although TBT is now largely banned for use in marine hull paints, it remains pervasive in the environment, and people can be exposed by ingesting TBT-contaminated seafood. Organotins may also leach into liquids that come into contact with organotin-containing plastic pipes, containers and packaging materials.

Blumberg categorizes TBT as an obesogen, a class of chemicals that promote obesity by increasing the number of fat cells and the storage of fat in existing cells or by altering metabolic regulation of appetite and satiety. He and his colleagues identified TBT as an obesogen in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.


Contact: Tom Vasich
University of California - Irvine

Related medicine news :

1. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
2. 3 types of fetal cells can migrate into maternal organs during pregnancy
3. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
4. Pregnant Mothers Gut Changes May Support Fetal Growth
5. Dangerous experiment in fetal engineering
6. Fetal alcohol exposure affects brain structure in children
7. U-M study shows BPA exposure in fetal livers
8. Plastics Chemical BPA Found in Fetal Livers
9. Prenatal Antidepressants Dont Raise Fetal, Infant Death Risk: Study
10. Treating sleep-disordered breathing in pregnancy may improve fetal health
11. Women and Infants Maternal-Fetal Medicine specialist selected for editorial team
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... During the National Family ... and held two webinars on topics of ‘Medical and Palliative Care Decisions,’ and ... . , With a loved one's diagnosis of mesothelioma, the closest ...
(Date:11/30/2015)... ... 2015 , ... Thermi™, a world leader in thermistor-regulated energy ... temperature controlled radiofrequency platform has received CE marking and may now be sold ... as a clinical endpoint. The technology has been available in the United ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... driverless vehicle experience this summer, ushering in a new era of publicly accessible ... and electric shuttle, will continue to offer guests an up-close look at the ...
(Date:11/30/2015)... Creek, Michigan (PRWEB) , ... November 30, 2015 , ... ... MI, the American Cancer Society held an annual fundraising event, a 5K walk known ... a holistic treatment center for substance abuse which is also located in Battle Creek, ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... off its annual fundraising campaign to raise funds for its research, education, support, ... 10% of the organization’s annual funding. , The Mesothelioma Applied Research Foundation, which ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015   Royal Philips ... the launch of Radiology Solutions, a fully integrated, ... Solutions comprises customized, data-driven practice management approaches that ... help radiology practices improve care delivery and reduce ... Radiological Society of North America Annual Meeting (RSNA) ...
(Date:11/30/2015)... , Nov. 30, 2015  IBA Molecular North ... and distribution of radiopharmaceuticals, announced that as of January ... Inc. (Zevacor Pharma). The decision to rebrand the company ... firm as well as its close relationship with Zevacor ... Illinois Health and Science (IHS). Peter ...
(Date:11/30/2015)... BOCA RATON, Fla. , Nov. 30, 2015 ... Public Research (the Institute) announced today that it ... a medical device start-up company with technology developed at ... based on publicly-funded research, and bridges early funding gaps ... -based universities and research institutions. ...
Breaking Medicine Technology: