Navigation Links
Fetal exposure to tributyltin linked to obesity
Date:1/24/2013

Irvine, Calif. (Corrected version) Exposing pregnant mice to low doses of the chemical tributyltin (TBT) which was used in marine antifouling paints and is used as an antifungal agent in some paints, certain plastics and a variety of consumer products can lead to obesity for multiple generations without subsequent exposure, a UC Irvine study has found.

After exposing pregnant mice to TBT at low concentrations, similar to those found in the environment and in humans, researchers observed increased body fat, liver fat and fat-specific gene expression in liver and stem cells in mouse "children," "grandchildren" and "great-grandchildren." The "children" were exposed as embryos, while the "grandchildren" may have been exposed as germ cells within the "children." The "great-grandchildren" had never been exposed to TBT. Such effects without exposure are termed transgenerational and thought to be permanently transmitted to future generations.

These findings demonstrate that early-life exposure to endocrine-disrupting compounds such as TBT can have permanent effects on fat accumulation, gene expression and stem cell programming without further exposure, said study leader Professor Bruce Blumberg with the UC Irvine Departments of Developmental & Cell Biology, Pharmaceutical Sciences and Biomedical Engineering.

The study appeared online Jan. 15 in Environmental Health Perspectives, a publication of the National Institute for Environmental Health Sciences.

Human exposure to TBT and related organotins can occur in a variety of ways. TBT contaminates particles derived from such products as shower curtains, vinyl flooring, carpet fibers, polyurethane foams, mold-resistant paints and other consumer products, where it is used as an antifungal agent. As a result, noteworthy levels of TBT have been reported in house dust, which may be particularly relevant for young children who can spend significant time on floors and carpets. Altho
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Presence of fetal cells in women lowers risk of breast cancer but raises risk of colon cancer
2. 3 types of fetal cells can migrate into maternal organs during pregnancy
3. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
4. Pregnant Mothers Gut Changes May Support Fetal Growth
5. Dangerous experiment in fetal engineering
6. Fetal alcohol exposure affects brain structure in children
7. U-M study shows BPA exposure in fetal livers
8. Plastics Chemical BPA Found in Fetal Livers
9. Prenatal Antidepressants Dont Raise Fetal, Infant Death Risk: Study
10. Treating sleep-disordered breathing in pregnancy may improve fetal health
11. Women and Infants Maternal-Fetal Medicine specialist selected for editorial team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 26, 2014 This is a ... the global Sterilizers industry with a focus on the ... market status of the Sterilizers manufacturers and is a ... individuals interested in the industry. This report provides a ... and manufacturing technology. In this part, the report presents ...
(Date:12/25/2014)... 25, 2014 Product liability lawsuits filed ... recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in ... Order issued in the U.S. District Court, Northern District ... an open conference on January 7, 2015, at the ... in West Palm Beach, Florida. The Conference is scheduled ...
(Date:12/25/2014)... Angeles, CA (PRWEB) December 25, 2014 The ... Dolcemaschio was created in honor of a true 9/11 ... at two film festivals including the 24 hours of Nuremberg ... Festival in Bangladesh. , Actress, screenwriter and director ... helped produce this film together with her husband, Gregory ...
(Date:12/25/2014)... When head lice hits a home or school, parents and ... of it while keeping it from taking over the house ... solution right in their neighborhood: Lice Troopers . Expanding ... spectrum head lice screening and treatment services to families and ... Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , The ...
(Date:12/25/2014)... News) -- Overeating is common during the holidays, but there ... expert says. "Don,t arrive at a party hungry. It ... you,ll be attending a party, but deprivation leads to hunger, ... Northern Westchester Hospital in Mount Kisco, N.Y., said in a ... the day and even to have a snack before attending ...
Breaking Medicine News(10 mins):Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... inhaled through hookah, research shows , FRIDAY, Dec. 4 (HealthDay ... smoking tobacco, researchers say. , A new study found that ... monoxide and nicotine, which puts them at risk for heart ... aged 18 to 50, who smoked tobacco using a water ...
... , JACKSONVILLE, Fla., Dec. 4 ... their work in improving the health of Florida,s uninsured and ... Sapphire Award ceremony. , The Sapphire Award is Florida,s only ... excellence in addressing health disparities within their communities. , Honorees ...
... , KINGFISHER, Okla., Dec. 4 United Country ... of the former Kingfisher Regional Hospital, according to Troy Lippard, ... on the South end of town," explained Lippard. "Therefore we ... which means it sells to the highest bidder with no ...
... A new study published this week in the Journal ... Juvenile Pilocytic Astrocytoma, or JPA, tumors in the thalamus of ... DTI. The sensitivity of DTI imaging allows for the ... information can maximize the potential of completely removing the tumor ...
... ... exclusive agreements in 2009 with USA IDN Health Systems and hospitals valued at $22.4 million ... end of 2009. , ... WA (PRWEB) December 4, 2009 -- PHACTS, LLC, a leader in Pharmacy Inventory Management Systems, ...
... BETHEL, Conn., Dec. 4 MedClean Technologies, Inc. (OTC Bulletin Board: ... purchase agreement with Socius Capital Group, LLC, a Delaware limited liability ... Pursuant to the Purchase Agreement, MedClean will receive up to $7.5 ... to 750 shares of its Series C Preferred Stock, in one ...
Cached Medicine News:Health News:Water Pipes No Safer Than Cigarettes 2Health News:Top Nonprofits Honored for Improving Health of Floridians 2Health News:Top Nonprofits Honored for Improving Health of Floridians 3Health News:Former Kingfisher Regional Hospital Property and Equipment to Sell at Absolute Public Auction 2Health News:PHACTS Receives $22.4 Million in New Business Commitments 2Health News:MedClean Technologies Enters Into Preferred Stock Agreement of Up to $7.5 Million 2Health News:MedClean Technologies Enters Into Preferred Stock Agreement of Up to $7.5 Million 3
(Date:12/24/2014)... , Dec. 24, 2014  The International Trade Commission ... ResMed (RMD) against BMC Medical. In a notice issued on ... found that ResMed,s patent on its humidifier was invalid. ... a "monumental win". "We are very excited with the ITC,s ... position that we have taken since the very beginning on ...
(Date:12/24/2014)... 2014  Diplomat Pharmacy, Inc. (NYSE: DPLO ... to announce Jennifer Hagerman , Pharm.D., AE-C, senior ... office as the president of the Michigan Pharmacists Association ... take place Feb. 28, 2015, at the MPA Annual ... Renaissance Center in Detroit, Michigan . ...
(Date:12/24/2014)... and LONDON , December 24, 2014 ... are expected to grow at an average rate of ... value and volume. Hip, knee and spine surgeries are ... in emerging economies they have a lower penetration. Increased ... the use of composites. Non-metallic orthopedic devices have gained ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
HemoSite meter can be used to measure the effects of transfusion or the treatment of deficiency states. It is fast, easy, convenient and discrete....
... test system is the worlds ... test system designed for use ... clinics, blood centers and emergency ... is designed for the point-of-care ...
... hemoglobin testing system (110V) ... for diabetes monitoring, sickle ... hemoglobinopathy screening and multiple ... test. It has bar ...
The Advia 60 is designed to deliver powerful performance in a small package....
Medicine Products: