Navigation Links
Fetal cell 'transplant' could be a hidden link between childbirth and reduced risk of breast cancer
Date:10/2/2007

PHILADELPHIA Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer. In Seattle, Washington, researchers at the University of Washington and Fred Hutchinson Cancer Research Center believe they have identified a source of this protective effect: fetal cells transplanted to the mother before birth.

Their findings are presented in the October 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

The ability of cells from a growing fetus to take up long-term residence within its mother is a phenomenon called fetal microchimerism. According to the researchers, while fetal microchimerism has been implicated as a mechanism of autoimmune disease, it may also benefit mothers by putting the immune system on alert for malignant cells to destroy.

To test the idea, the researchers recruited 82 women, 35 of whom had been diagnosed with breast cancer. Approximately two-thirds of the women studied have had children, and more than half of the participants had given birth to at least one son. The researchers took blood samples from each participant and searched them for male DNA, as they reasoned it is a relatively definitive matter to detect the male Y chromosome amid the mothers native and obviously female cells within a blood sample.

Among the women with breast cancer, only five had male DNA in their bloodstream. Three of the five previously gave birth to sons, one had had an abortion and the other had never been knowingly pregnant. In total, about 14 percent of all women in the breast cancer group had male DNA in their bloodstream compared to 43 percent of women in the non-breast cancer group.

"Our research found that these persisting fetal cells may be giving a woman an edge against developing breast cancer, said lead author Vijayakrishna K. Gadi, M.D., Ph.D., assistant professor at the University of Washington and research associate at the Fred Hutchinson Cancer Research Center. This experiment of nature is all the more fascinating because for years doctors treated a number of different cancers by transplanting cells from one person to another."

According to Dr. Gadi, these findings could provide a starting point for future research on the role of fetal microchimerism in the prevention of cancer. In addition, there are other reasons for male DNA to be in a womans peripheral blood, such as miscarriage and abortion or possibly even blood transfusion or a male twin that was reabsorbed into the womb at an early stage of the pregnancy.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Anthrax drug doxycycline could stunt fetal growth
2. Fish Found To Improve Fetal Growth
3. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
4. Epidural can affect the fetal head position
5. Pomegranate juice to check fetal brain injury
6. Vitamin Supplements During Pregnancy to Boost Fetal Development
7. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
8. Using Eyes As The Line Of Reference For Fetal Brain Imaging
9. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
10. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
11. Fetal Development Face The Threat By Frequent Ultrasounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... ... The V Foundation for Cancer Research, a top-rated cancer research charity, announced ... to compete in the Boston Marathon on April 17. From first-time participants to ... marathon to join Team V and support the Foundation’s mission to declare victory over ...
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their ... that they have achieved certification to ISO 13485. This certification is another way they ... to date products and services that they need. , The ISO 13485 Certification is ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, the ... Technology (ABT), an innovative braking system that allows skaters of all levels to ... of the biggest concerns of beginner and intermediate skaters – learning how to ...
(Date:1/17/2017)... New York, NY (PRWEB) , ... January 17, 2017 , ... ... the grand opening of a new showroom at South Dixie Hwy in Miami, FL. ... Marketing Officer at Gym Source. “The new innovative in-store concept is designed to give ...
(Date:1/17/2017)... Tampa, Fla (PRWEB) , ... January 17, 2017 , ... ... IT Excellence Award for Innovation of the Year. , Each year, Pink ... has taken an innovative approach to address a specific business problem or opportunity. The ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... The Philadelphia Pediatric Medical Device Consortium (PPDC) has announced seed ... Consortium chose those companies from eight finalists in ... The devices under development are a powered orthotic arm ... delivery system for emergency situations and a device that gradually ... ...
(Date:1/18/2017)... BETHESDA, Md. , Jan. 18, 2017 /PRNewswire/ ... in the coffee family, are often used to ... are consumed by several million Americans annually to ... as a natural remedy for minor aches and ... kratom,s effects is intended to assist FDA and ...
(Date:1/18/2017)... de enero de 2017  Hoy, en el Foro ... una iniciativa global para avanzar el acceso a la ... países de renta baja y baja-media (LICs y LMICs). ... de crisis, particularmente en países de renta baja y ... de las muertes relacionadas con NCD. El objetivo de ...
Breaking Medicine Technology: