Navigation Links
Fetal cell 'transplant' could be a hidden link between childbirth and reduced risk of breast cancer
Date:10/2/2007

PHILADELPHIA Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer. In Seattle, Washington, researchers at the University of Washington and Fred Hutchinson Cancer Research Center believe they have identified a source of this protective effect: fetal cells transplanted to the mother before birth.

Their findings are presented in the October 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

The ability of cells from a growing fetus to take up long-term residence within its mother is a phenomenon called fetal microchimerism. According to the researchers, while fetal microchimerism has been implicated as a mechanism of autoimmune disease, it may also benefit mothers by putting the immune system on alert for malignant cells to destroy.

To test the idea, the researchers recruited 82 women, 35 of whom had been diagnosed with breast cancer. Approximately two-thirds of the women studied have had children, and more than half of the participants had given birth to at least one son. The researchers took blood samples from each participant and searched them for male DNA, as they reasoned it is a relatively definitive matter to detect the male Y chromosome amid the mothers native and obviously female cells within a blood sample.

Among the women with breast cancer, only five had male DNA in their bloodstream. Three of the five previously gave birth to sons, one had had an abortion and the other had never been knowingly pregnant. In total, about 14 percent of all women in the breast cancer group had male DNA in their bloodstream compared to 43 percent of women in the non-breast cancer group.

"Our research found that these persisting fetal cells may be giving a woman an edge against developing breast cancer, said lead author Vijayakrishna K. Gadi, M.D., Ph.D., assistant professor at the University of Washington and research associate at the Fred Hutchinson Cancer Research Center. This experiment of nature is all the more fascinating because for years doctors treated a number of different cancers by transplanting cells from one person to another."

According to Dr. Gadi, these findings could provide a starting point for future research on the role of fetal microchimerism in the prevention of cancer. In addition, there are other reasons for male DNA to be in a womans peripheral blood, such as miscarriage and abortion or possibly even blood transfusion or a male twin that was reabsorbed into the womb at an early stage of the pregnancy.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Anthrax drug doxycycline could stunt fetal growth
2. Fish Found To Improve Fetal Growth
3. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
4. Epidural can affect the fetal head position
5. Pomegranate juice to check fetal brain injury
6. Vitamin Supplements During Pregnancy to Boost Fetal Development
7. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
8. Using Eyes As The Line Of Reference For Fetal Brain Imaging
9. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
10. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
11. Fetal Development Face The Threat By Frequent Ultrasounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... ... For many women, getting birth control isn’t as easy as it should be. In fact, ... to a health care facility or a pharmacy within 60 minutes of where they live. ... for many who are faced with health or personal issues that leave them homebound. To ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... to be invited to the Siemens Healthineers annual customer education symposium, a world-class ... will take place from March 27 - 31, 2017 at the Atlanta Marriott ...
(Date:3/28/2017)... ... ... Isabella Wentz, PharmD, FASCP, one of the leading thyroid experts of the world, is ... about journey and research recently on a blog and discussed some major aspects of ... deal with thyroid disease. , Dr. Wentz completed her graduation from the Midwestern ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... medical society dedicated to advancing the science and clinical practice of radiosurgery, ... RSSearch Patient Registry, a multi-institutional, observational registry established to standardize data collection ...
(Date:3/28/2017)... ... 28, 2017 , ... Z-Medica, LLC, a leading developer and ... (UPMC) will acquire QuikClot® Bleeding Control Kits® (BCK) to equip up to 1,000 ... efforts by the American College of Surgeons, U.S. Department of Defense, Department of ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... CITY, Calif. , March 28, 2017 /PRNewswire/ ... company focused on the development and commercialization of ... pain, announced that the European Medicines Agency (EMA) ... sublingual tablet, 30 mcg) Marketing Authorisation Application (MAA) ... of the MAA is underway. The MAA for ...
(Date:3/28/2017)... Mass. , March 28, 2017 ... company developing innovative therapeutics that address significant unmet ... a patent from the Japan Patent Office (JPO) ... connective tissue growth factor (CTGF) for the treatment ... limited to skin fibrosis and proliferative retinopathy (Japanese ...
(Date:3/28/2017)... , March 28, 2017 The ... reach USD 8.0 billion by 2025, according to a ... incidence of infectious diseases and cancer is expected to ... disease diagnosis over the coming years. In addition, higher ... autologous and allogenic stem cell therapy, due to adverse ...
Breaking Medicine Technology: