Navigation Links
Fetal cell 'transplant' could be a hidden link between childbirth and reduced risk of breast cancer
Date:10/2/2007

PHILADELPHIA Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer. In Seattle, Washington, researchers at the University of Washington and Fred Hutchinson Cancer Research Center believe they have identified a source of this protective effect: fetal cells transplanted to the mother before birth.

Their findings are presented in the October 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

The ability of cells from a growing fetus to take up long-term residence within its mother is a phenomenon called fetal microchimerism. According to the researchers, while fetal microchimerism has been implicated as a mechanism of autoimmune disease, it may also benefit mothers by putting the immune system on alert for malignant cells to destroy.

To test the idea, the researchers recruited 82 women, 35 of whom had been diagnosed with breast cancer. Approximately two-thirds of the women studied have had children, and more than half of the participants had given birth to at least one son. The researchers took blood samples from each participant and searched them for male DNA, as they reasoned it is a relatively definitive matter to detect the male Y chromosome amid the mothers native and obviously female cells within a blood sample.

Among the women with breast cancer, only five had male DNA in their bloodstream. Three of the five previously gave birth to sons, one had had an abortion and the other had never been knowingly pregnant. In total, about 14 percent of all women in the breast cancer group had male DNA in their bloodstream compared to 43 percent of women in the non-breast cancer group.

"Our research found that these persisting fetal cells may be giving a woman an edge against developing breast cancer, said lead author Vijayakrishna K. Gadi, M.D., Ph.D., assistant professor at the University of Washington and research associate at the Fred Hutchinson Cancer Research Center. This experiment of nature is all the more fascinating because for years doctors treated a number of different cancers by transplanting cells from one person to another."

According to Dr. Gadi, these findings could provide a starting point for future research on the role of fetal microchimerism in the prevention of cancer. In addition, there are other reasons for male DNA to be in a womans peripheral blood, such as miscarriage and abortion or possibly even blood transfusion or a male twin that was reabsorbed into the womb at an early stage of the pregnancy.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Anthrax drug doxycycline could stunt fetal growth
2. Fish Found To Improve Fetal Growth
3. Fetal Cell Transplant Found To Improve Movement In Patients With Parkinson’s Disease
4. Epidural can affect the fetal head position
5. Pomegranate juice to check fetal brain injury
6. Vitamin Supplements During Pregnancy to Boost Fetal Development
7. Worried About The Sensitive Skin Of Your 2 Year Old? Fetal Skin Cells To Offer Help
8. Using Eyes As The Line Of Reference For Fetal Brain Imaging
9. Simple Eye Movement Test For Early Detection Of Fetal Alcohol Spectrum Disorder
10. Genetic Disorders, Not Fetal Distress Increase Cerebral Palsy Risk
11. Fetal Development Face The Threat By Frequent Ultrasounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... BC (PRWEB) , ... July 26, 2017 , ... ... (the “Company” or “Isodiol”) a global cannabis innovator, specializing in the development of ... the period from April 1, 2017 to June 30, 2017. Iso International LLC ...
(Date:7/26/2017)... ... 26, 2017 , ... The number of adults 65 years or older is ... improve asthma control in the population are not well described. In a study published ... official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI), researchers identified ...
(Date:7/25/2017)... ... July 25, 2017 , ... Creative Pharmacist and ... provide the Pharmacist eCare Plan to Computer-Rx pharmacies through the STRAND ... ability to develop the Pharmacist eCare Plan, a shared document detailing a patient’s ...
(Date:7/25/2017)... ... July 25, 2017 , ... Nautilus Hyosung ... States, today announced its partnership with financial technology company, Automated Transaction Delivery (ATD), ... the solution lies within Hyosung’s superior ATMs, assisted self-service devices and associated software. ...
(Date:7/25/2017)... ... 2017 , ... SignatureCare Emergency Center – South Austin is treating both adult ... day. , The Emergency Room opened early March, making it the ... now and things are running smoothly,” said Aaron Braun, SignatureCare Emergency Center’s Chief Medical ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... International plc (NASDAQ: ENDP ) will announce its second-quarter ... senior management team will host a conference call and webcast before ... The dial-in number to access the call is U.S./ ... is 45397076. Please dial in 10 minutes prior to the scheduled ... of the call will be available from August 8, 2017 at ...
(Date:7/12/2017)... -- CarpalAID is a revolutionary new product that relieves painful carpal ... tunnel syndrome affects more than 8 million people a year. Women ... The common methods of treating CTS are painful surgery, the use ... gloves. ... CarpalAID is a clear patch worn on the palm of the ...
(Date:7/11/2017)... 11, 2017  Sysmex America, Inc., a leading ... equipment as well as middleware information systems technology, ... make quality assurance easier and more risk free ... known for the innovation that it delivers to ... quality assurance processes to a new level with ...
Breaking Medicine Technology: