Navigation Links
Fetal Gene May Contribute to Diabetes Risk
Date:5/8/2008

ility of DNA to be transcribed, or send messages out to the rest of the body, she said.

Researchers were previously able to normalize the activity of the Pdx1 gene in both newborn and adult animals with diabetes, using the drug Byetta (Exendin-4). It's not clear yet if the drug can also reverse epigenetic changes. The drug comes from Gila monster saliva, Simmons said.

But investigators face a huge technical hurdle trying to confirm these findings in humans.

"We do know this process [gene silencing] occurs in humans, particularly in cancer with tumor suppressor genes," Simmons explained. "What we don't know is if this process is responsible, in humans, for changes that we see in growth-retarded babies growing up."

"We'd like to think this is the case [that the same process is at work in humans], but we have no way right now to determine that," Simmons continued.

If the same mechanism is at work in humans, the Pdx1 gene may present a good target for drug therapy to prevent the development of type 2 diabetes, she said.

More information

Visit the American Diabetes Association for more on type 2 diabetes.



SOURCES: Rebecca A. Simmons, M.D., associate professor, pediatrics, University of Pennsylvania School of Medicine, Philadelphia; May 2008 Journal of Clinical Investigation


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

0

GOOD

Page: 1 2

Related medicine news :

1. Mothers Blood Could Offer Insights Into Fetal Health
2. Residual fetal cells in women may provide protection against breast cancer
3. Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer
4. Fetal Surgery Saves Baby After Early Water Break
5. Fetal heart rate yields clues to childrens later development
6. Fetal Heart Rate Points to Later Child Development
7. Fetal Exposure to Arsenic Affects Genes
8. Procedure to detect fetal heart defects is first automated use of 3-D ultrasound
9. Fetal Alcohol Exposure May Prime Offspring for Alcoholism
10. Fetal surgeon shows for first time that laser procedure may treat vasa previa
11. Eye Blinks May ID Fetal Alcohol Exposure

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2009)... The Onder Law Firm’s attorneys a...families of those who may have experienced heart a...er taking XOLAIR. , St. L...w Firm are among attorneys offering free XOLAIR c...art attack and stroke. The attorneys of the Onder...
(Date:11/22/2009)...v. 22 2009) -- Physician-scientists from Weill Cor...echanism that may prove to be a powerful target fo...of cancer that affects lymphocytes, or white blood...have been able to powerfully suppress tumor format...sing results have led to the design of a clinical ...
(Date:11/22/2009)... The holiday season is filled with get-...fun and joyous. It can also be stressful and tirin... stress, fatigue, and high fat foods -- factors th...hat,s why the National Foundation for Cancer Resea...can help ensure a happier, more healthful holiday ...
(Date:11/21/2009)...SHINGTON, Nov. 21 DNC C...fter the Senate voted to begin full debate of heal...tp://www.newscom.com/cgi-bin/prnh/20080519/DNCLOGO...c step on the road to enacting health insurance re...nators will now have an opportunity to debate the ...
(Date:11/21/2009)...ssociation Discusses Key Provisions of Legislation...m ,, ST. CHARLES, Ill., Nov. 21 /PRNewswire-US...ves passing the landmark Affordable Health Care fo...ey health reform legislation forward, Congress has...ealth care system. Today, AARP hosted an educatio...
Breaking Medicine News(10 mins):Health News:The Attorneys of The Onder Law Firm Offers Free XOLAIR Case Review 2Health News:New cancer target for non-Hodgkin's lymphoma 2Health News:Top 10 Food Tips for the Holidays from the National Foundation for Cancer Research 2Health News:Top 10 Food Tips for the Holidays from the National Foundation for Cancer Research 3Health News:Democratic National Committee Chairman Tim Kaine's Statement on the Senate's Vote to Proceed to Full Floor Debate of Health Insurance Reform Legislation 2Health News:AARP Hosts Rep. Bill Foster In Health Care Reform Forum 2
...ollowing high incidence of a potentially dangerous... lens solution, manufactured by Bausch & Lomb//, t...ted regarding the same and the controversial produ...le to claim that the product is safe to use. All u...
... new study indicates that people suffering from sy...ave decreased intake of vitamin C and manganese co...e written in the medical journal ‘Thorax’ by Dr N....led that the fruit consumption on an average was 1...
...s the indefinite strike by doctors belonging to fi..., hundreds of patients, especially from weaker sec...dicos denied treatment for them. Hospital gua...ep waiting for hours before going away disappointe...
...esearchers from Oxford University's Health Economi...e UK a staggering ?29 billion each year.// This is...get. The findings of the study are reported in the...ity and the rest in informal care. The report is b...
...he visiting Executive Director of United Nations P...angladesh has attained progress //in some sectors,...e health sector to become an advanced country. ...education and primary healthcare services Banglade...
... major concern for any mother with a child in day ...d with his daycare provider than with his mother./.../June issue of the journal Child Development shoul...ty of Dresden, all in Germany, and the University ...
Other Medicine News:Health News:Patients Bear The Brunt Of Doctor’s Strik 2Health News:Bangladesh Progressing But Must Yet Face Challenges In Health Sector 2Health News:Mamas Can Set Their Minds to Rest 2
(Date:11/20/2009)..., , WAYNE, Pa., Nov. 20 /PRNewswire-FirstCa... announced the results for its fiscal first quarte...quarter of fiscal 2010, product revenue decreased ...ing the three-month period ended September 30, 200... The Company reported the decreased net revenue o...
(Date:11/20/2009)..., , CARY, N.C., Nov. 20 /PRNewswire-FirstC...TX ), a specialty pharmaceutical company focused o...icant products primarily for the respiratory and r...d a Warning Letter from the Food and Drug Administ...ble tablets (Phenylephrine HCl 10 mg, Pyrilamine M...
(Date:11/20/2009)..., , NEW YORK, Nov. 20 /PRNewswire-FirstCal...s today contributing to a transformation in Americ...paradigm that is already delivering higher quality...curve downward -- making medicine smarter for the ...mpany today explained how the elements in its stra...
Breaking Medicine Technology:Escalon(R) Reports First Quarter Fiscal 2010 Results 2Escalon(R) Reports First Quarter Fiscal 2010 Results 3Escalon(R) Reports First Quarter Fiscal 2010 Results 4Escalon(R) Reports First Quarter Fiscal 2010 Results 5Escalon(R) Reports First Quarter Fiscal 2010 Results 6Escalon(R) Reports First Quarter Fiscal 2010 Results 7Cornerstone Therapeutics Provides a Response to FDA Warning Letter on Deconsal 2Cornerstone Therapeutics Provides a Response to FDA Warning Letter on Deconsal 3Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 2Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 3Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 4Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 5Some skin cancer may be mediated by primary cilia activity 9670 1Some skin cancer may be mediated by primary cilia activity 9670 2Some skin cancer may be mediated by primary cilia activity 9670 3Soothe Back to School Anxiety Teach Kids to Relax 55080 1Soothe Back to School Anxiety Teach Kids to Relax 55080 2eMedical Systems Inc Selects MPMsoft as its Medical Billing Software Solution 55078 1eMedical Systems Inc Selects MPMsoft as its Medical Billing Software Solution 55078 2eMedical Systems Inc Selects MPMsoft as its Medical Billing Software Solution 55078 3
...d ATLANTA, US, May 14, 2007 - SkyePharma PLC,(LSE:...SCRX) today,announce the successful completion of ...on of Sular, a calcium ,channel blocking agent for...esults showed that the new Sular formulation is,bi... The new,Sular formulation utilizes SkyePharma,s p...
... from placebo,controlled phase IIa study in patien...EREN (Zurich), Switzerland, May 15, 2007 - Cytos B... results from a multi-centre,and placebo-controlle...YT003-QbG10, an immunotherapeutic product candidat...y included 40 patients,suffering from mild to mode...
Other Medicine Technology:SkyePharma and Sciele Pharma Announce Successful Completion of New,Sular Formulation Clinical Trial Programme 2SkyePharma and Sciele Pharma Announce Successful Completion of New,Sular Formulation Clinical Trial Programme 3Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 2Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 3Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 4Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 5Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 6Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy 7
Troutman-Barraquer Corneal Utility Forceps, Colibri Style - 0.5 mm
Catalano Corneal Scleral Forceps
Troutman-Barraquer Corneal Utility Forceps, Colibri Style
Colibri Forceps 0.12 mm
Medicine Products: