Navigation Links
Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
Date:7/4/2012

Istanbul, 4 July 2012: Although the first successful preservation of fertility from the freezing, thawing and grafting of ovarian tissue was reported eight years ago,(1) the technique has remained experimental and confined to a few specialist centres. Now, with the announcement of a first pregnancy (and subsequent live birth) in Italy following the transplantation of ovarian tissue, there are indications that fertility preservation is moving into the mainstream of reproductive medicine and into a greater number of centres.(2)

"Fertility preservation is now a key component of the management of young cancer patients," said Dr Gianluca Gennarelli from Clinica Universitaria Sant'Anna in Turin, presenting details of the Italian pregnancy at the annual meeting of ESHRE (European Society of Human Reproduction and Embryology). "Though still a challenging procedure, the cryopreservation of ovarian cortex should still be offered to young women and girls ahead of potentially gonadotoxic cancer treatments with a high risk of ovarian failure," he said.

The Italian case described by Dr Gennarelli was remarkable not just because it is Italy's first successful pregnancy and delivery, but also because - with a gap of seven years - it represents one of the longest time intervals yet between the date of tissue freezing and the date of successful transplantation.(3) "It demonstrates that pregnancy can be obtained by this technique even after several years of cryostorage," said Dr Gennarelli.

The case involved a 21-year-old patient scheduled for high dose chemotherapy and bone marrow transplantation. Just before treatment, in July 2003, she was referred for fertility preservation, with ovarian cortical tissue collected by laparoscopy. Bilateral biopsies of ovarian cortex were sampled (ie, from both ovaries), frozen by slow freezing and stored in liquid nitrogen. As feared, chemotherapy was followed by ovarian failure.

In March 2010, following the patient's request and investigation for fertility restoration, 32 cortical tissue fragments were thawed and sutured to prepared sites. Two months after the tissue grafting, some ovarian function returned and spontaneous follicular development was observed. Over the following months spontaneous menstrual cycles were repeatedly evident and ovulation was confirmed in at least six cycles. In July 2011, 15 months after the ovarian tissue transplantation, the patient became spontaneously pregnant, and a healthy baby was delivered in March 2012.

The birth is believed to be the 22nd in the world from this technique, and a new indication that the restoration of fertility by this technique is feasible, rapidly evolving and worthwhile for a growing number of patients. Given the increase in cancer survival, and the likelihood that many successfully treated young women and girls will live to enjoy their "reproductive" years, interest in the technique - from both patients and doctors - is sure to grow, said Dr Gennarelli.

The cryopreservation of ovarian tissue is not the only technique suitable for young women, and there is also growing interest in oocyte cryopreservation (especially with developments in vitrification). However, both embryo and oocyte storage require a cycle of ovarian stimulation and collection, which may not be suitable for women with hormone-dependent cancers or for those who need immediate cancer treatment. The storage of ovarian tissue - which may be performed at short notice - overcomes both those problems.

Nevertheless, Dr Gennarelli conceded that the number of successful cases of fertility restoration is not great, especially in relation to the number of tissue samples now in storage. A further poster presented at this congress - from some of the leading groups in the field - reported that most patients having autologous transplantation of ovarian tissue did so with the intention of having a child, but the recovery of hormonal function was also very important to them. Most transplanted women did recover their ovarian function.(4)

"We and other groups now believe that ovarian tissue freezing for fertility preservation should not be considered experimental but be recognised as a routine clinical practice to be offered in appropriate cases," said Dr Gennarelli. "Age, for example, is one important consideration."

On the question of time between tissue biopsy, freezing and transplantation, Dr Gennarelli said: "We are not aware, so far, of any time limit for cryopreserved ovarian tissue. The recent report by the group of Jacques Donnez further prolongs that time interval even further."

Despite the wider application of ovarian tissue storage for fertility preservation, the relatively small number of babies born suggests that far fewer women after their cancer treatment are taking up their options for pregnancy. "The reasons are probably many," said Dr Gennarelli, "but the simplest might be that not so many patients have reached the age or the decision to conceive. Nevertheless, the babies born worldwide so far indicate that we're moving in the right direction."


'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Men and women receive different fertility advice following cancer diagnosis
2. Men and Women With Cancer May Receive Different Fertility Information
3. Could Fertility Drugs Make Kids Shorter?
4. Under Right Conditions, Fertility Treatment Can Equal Natural Conception Rates: Study
5. Success of fertility treatment may approach natural birth rate
6. Childless women with fertility problems at higher risk of hospitalization for psychiatric disorders
7. Heavy Coffee Intake May Affect Fertility Treatments: Study
8. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
9. U.S. Panel Rejects Ovarian Cancer Screening
10. UC Irvine study finds racial, economic disparities in ovarian cancer care, survival
11. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
Breaking Medicine Technology: