Navigation Links
Feinstein Institute researchers show a genetic overlap in schizophrenia and cognitive ability
Date:12/17/2013

MANHASSET, NY Investigators at The Feinstein Institute for Medical Research have discovered for the first time, direct evidence of a genetic overlap between schizophrenia and general cognitive ability. The findings are published online in Molecular Psychiatry.

Schizophrenia is a chronic, severe and disabling brain disorder that affects approximately 2.2 million Americans each year. It is characterized by a significant reduction in general cognitive abilities, so that many patients struggle with completing school, holding jobs and achieving their full potential. Previous studies have indicated subtle cognitive abnormalities in undiagnosed and unmedicated relatives of patients who live with schizophrenia, which suggests the possibility of genetic overlap between risk for schizophrenia and cognitive traits. These previous studies, however, did not test this overlap on the molecular level.

Anil Malhotra, MD, director of psychiatry research at Zucker Hillside Hospital and an investigator at the Feinstein Institute, and his colleague Todd Lencz, PhD, associate investigator at the Zucker Hillside Hospital and the Feinstein Institute, conducted the first molecular genetic test to determine if genetic markers of reduced cognitive ability were also genetic markers of increased schizophrenia risk. Specifically, they conducted a large-scale, meta-analysis, genome-wide association study (GWAS) of samples from 5,000 subjects provided by the Cognitive Genomics consorTium (COGENT). COGENT, which was founded and is led by Dr. Malhotra, is an international consortium of nine teams of researchers across seven countries. Through their analysis, they confirmed that patients who suffered from schizophrenia also had lessened cognitive ability. This is the first direct evidence for genetic overlap between schizophrenia risk genes and genes that regulate general cognitive ability, such as memory, attention, and language abilities. The results provide molecular confirmation of this genetic overlap and additional insight into how schizophrenia develops and progresses.

"This research leads us to a deeper understanding of how schizophrenia affects the brain at the molecular level," said Dr. Lencz. "Our studies are designed to provide clues to the development of new treatments to improve the lives of our patients."


'/>"/>

Contact: Emily Ng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related medicine news :

1. Feinstein Researcher Receives 2013 Best of Manhasset Award
2. Feinstein Institute Encourages Science Education for NY Area Middle and High School Students
3. Feinstein Institute Researcher Organizes LI Alzheimer’s Consortium
4. Feinstein Institute to Receive $330,000 Grant to Support Research of Childhood Cancer
5. North Shore-LIJ Health System's Feinstein Institute to Receive $250,000 Grant from Lymphoma Research Foundation Grant to support research of Chronic Lymphocytic Leukemia
6. Summer Benefit Concert Raised More Than $1.5 Million for Feinstein Institute
7. Long Island Bike Challenge Rides to Raise Money for North Shore-LIJ's Feinstein Institute of Medical Research
8. Feinstein Institute, Hofstra North Shore-LIJ School of Medicine at 36th Annual Conference on Shock
9. North Shore-LIJ's Feinstein Institute Hosts Academic Commencement and Convocation
10. North Shore-LIJ's Feinstein Institute Celebrates Women in Science During National Women’s Health Week
11. Feinstein Institute Researcher provides insight into osteoarthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone ... executive with extensive sequencing and genomics experience, as Vice President of North American Capital ... will be responsible for leading the sales team in the commercialization of the HTG ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
Breaking Medicine Technology: