Navigation Links
Feinstein Institute researchers discover plant derivative
Date:11/15/2012

MANHASSET, NY Researchers at The Feinstein Institute for Medical Research have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis. The findings are published in the December issue of Biochemical Pharmacology.

Inflammation is necessary for maintaining good health without inflammation, wounds and infections would never heal. However, persistent and constant inflammation can damage tissue and organs, and lead to diseases such as sepsis. Sepsis affects approximately 750,000 Americans each year, 28 to 50 percent of whom die from the condition, and costs the nation's healthcare system nearly $17 billion annually. It is a potentially life-threatening complication of an infection or injury, and occurs when chemicals released into the bloodstream to fight the infection trigger inflammation throughout the body. The result is that organs become damaged, including liver, heart, lungs, kidney and brain. If excessive damage occurs, it may be irreversible. For years, Feinstein Institute researchers have been trying to identify ways to halt persistent and constant inflammation.

Tanshinones have been used for treatment of cardiovascular and cerebrovascular diseases. Based on research on mice conducted by Haichao Wang, PhD, and his colleagues, including Kevin J. Tracey, MD, and Andrew E. Sama, MD, at the Feinstein Institute, tanshinone IIA sodium sulfonate (TSN-SS) effectively inhibited the release of HMGB1 outside of cells. HMGBI is a deoxyribonucleic acid (DNA) protein that mediates inflammation and, if over expressed, causes sepsis. Furthermore, Dr. Wang and his colleagues previously discovered that inhibition of HMGB1 by TSN-SS protected against sepsis-induced animal mortality and cardiovascular dysfunction in animals.

"Dr. Wang's research on TSN-SS has uncovered details that offer a new mechanism for intracellular drug delivery," said Sarah Dunsmore, Ph.D., of the National Institutes of Health's National Institute of General Medical Sciences, which partially supported the work. "These findings have broad significance and implications for treating a variety of conditions, including cancer, sepsis and Alzheimer's disease."

The NIH grant numbers that supported this study are AT005076 and GM063075.

The Feinstein Institute, in alliance with the Cleveland Clinic, is exploring opportunities to commercialize patent technologies relating to the use of TSN-SS in the treatment of human diseases.

"This novel therapy opens up more applications for the use of Chinese traditional medicine in western medicine, and it is my hope that it will be tested for efficacy in sepsis clinical trials in the near term." said Dr. Wang.


'/>"/>

Contact: Emily Ng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related medicine news :

1. Feinstein Institute to receive grant to improve schizophrenia treatment
2. Feinstein Institute to Receive Grant from Centers for Medicare & Medicaid Services to Improve Schizophrenia Treatment
3. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
4. Feinstein announces submission of new drug application for diagnosing parkinsonian syndromes
5. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
6. Bascom Palmer Eye Institute announces breakthrough for degenerative vision disorder
7. The Ludwig Institute for Cancer Research announces launch of iTeos Therapeutics SA
8. A North American first at the Montreal Heart Institute
9. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
10. Data release from the Allen Institute for Brain Science expands online atlas offerings
11. Los Robles Hospital’s Annual Health Fair Attended by Khanna Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 26, 2017 , ... ... lab became the world’s first to be ISO/IEC 17025:2005 INAB accredited for Der ... , ISO/IEC 17025:2005 is the globally recognised standard that sets out requirements for ...
(Date:2/26/2017)... , ... February 26, 2017 , ... ... wholesale distribution in North America, today announced it would be offering some it’s ... which prides itself on crafting quality and unique baby clothing/feeding products, will team ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... standard in staffing, scheduling, and reporting for healthcare organizations. This comprehensive and ... the entire staffing process. StaffBridge technology improves staffing efficiency, maximizes resource allocation, ...
(Date:2/26/2017)... Florida (PRWEB) , ... February 26, 2017 , ... ... (PD) patients after receiving cognitive rehabilitation, according to a study released today at ... known that cognitive rehabilitation programs are proven to be effective in improving cognitive ...
(Date:2/25/2017)... ... 25, 2017 , ... FCPX users now have the ability to sharpen a ... ProSharpen Color users have total control over sharpening amount, sharpening radius, threshold, horizontal sharpening, ... spectrum tools users can visually see the color range effected with ease all within ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Israel and TAMPA, Fla. , ... an emerging medical device company focused on developing ... procedures, applauds the members of the FDA,s Circulatory ... for their acknowledgement of the need for cerebral ... "The statements shared by this FDA ...
(Date:2/27/2017)... 2017 Now in its seventh year, ... are most successful at developing and commercialising innovation. ... The Index can ... molecule to two different companies in early phase, which would ... objective analysis of each company,s performance between 2011 and 2016, the 2017 ...
(Date:2/27/2017)... Period October – December 2016 ... to SEK -16.4 (-6.4) million Result after tax amounted to ... after dilution Cash flow from operating activities amounted to SEK ... Period full ... Operating result amounted to SEK -39.5 (-29.5) million ...
Breaking Medicine Technology: