Navigation Links
Feinstein Institute researchers discover plant derivative
Date:11/15/2012

MANHASSET, NY Researchers at The Feinstein Institute for Medical Research have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis. The findings are published in the December issue of Biochemical Pharmacology.

Inflammation is necessary for maintaining good health without inflammation, wounds and infections would never heal. However, persistent and constant inflammation can damage tissue and organs, and lead to diseases such as sepsis. Sepsis affects approximately 750,000 Americans each year, 28 to 50 percent of whom die from the condition, and costs the nation's healthcare system nearly $17 billion annually. It is a potentially life-threatening complication of an infection or injury, and occurs when chemicals released into the bloodstream to fight the infection trigger inflammation throughout the body. The result is that organs become damaged, including liver, heart, lungs, kidney and brain. If excessive damage occurs, it may be irreversible. For years, Feinstein Institute researchers have been trying to identify ways to halt persistent and constant inflammation.

Tanshinones have been used for treatment of cardiovascular and cerebrovascular diseases. Based on research on mice conducted by Haichao Wang, PhD, and his colleagues, including Kevin J. Tracey, MD, and Andrew E. Sama, MD, at the Feinstein Institute, tanshinone IIA sodium sulfonate (TSN-SS) effectively inhibited the release of HMGB1 outside of cells. HMGBI is a deoxyribonucleic acid (DNA) protein that mediates inflammation and, if over expressed, causes sepsis. Furthermore, Dr. Wang and his colleagues previously discovered that inhibition of HMGB1 by TSN-SS protected against sepsis-induced animal mortality and cardiovascular dysfunction in animals.

"Dr. Wang's research on TSN-SS has uncovered details that offer a new mechanism for intracellular drug delivery," said Sarah Dunsmore, Ph.D., of the National Institutes of Health's National Institute of General Medical Sciences, which partially supported the work. "These findings have broad significance and implications for treating a variety of conditions, including cancer, sepsis and Alzheimer's disease."

The NIH grant numbers that supported this study are AT005076 and GM063075.

The Feinstein Institute, in alliance with the Cleveland Clinic, is exploring opportunities to commercialize patent technologies relating to the use of TSN-SS in the treatment of human diseases.

"This novel therapy opens up more applications for the use of Chinese traditional medicine in western medicine, and it is my hope that it will be tested for efficacy in sepsis clinical trials in the near term." said Dr. Wang.


'/>"/>

Contact: Emily Ng
eng3@nshs.edu
516-562-2670
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related medicine news :

1. Feinstein Institute to receive grant to improve schizophrenia treatment
2. Feinstein Institute to Receive Grant from Centers for Medicare & Medicaid Services to Improve Schizophrenia Treatment
3. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
4. Feinstein announces submission of new drug application for diagnosing parkinsonian syndromes
5. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
6. Bascom Palmer Eye Institute announces breakthrough for degenerative vision disorder
7. The Ludwig Institute for Cancer Research announces launch of iTeos Therapeutics SA
8. A North American first at the Montreal Heart Institute
9. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
10. Data release from the Allen Institute for Brain Science expands online atlas offerings
11. Los Robles Hospital’s Annual Health Fair Attended by Khanna Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 22, 2017  As the latest Obamacare repeal effort ... Cassidy (R-LA) and Lindsey Graham (R-SC) ... medical device industry is in an odd place.  The ... 2.3% excise tax on medical device sales passed along ... covered patients, increased visits and hospital customers with the ...
(Date:9/19/2017)... medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound energy ... ... Jim Bertolina, PhD ... Tom Tefft ... executive Josh Stopek , PhD, who has led R&D and business development teams at ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
Breaking Medicine Technology: