Navigation Links
Feinstein Institute Researcher provides insight into osteoarthritis

MANHASSET, NY A researcher at The Feinstein Institute for Medical Research has discovered additional mechanical properties of articular cartilage, a protective cartilage on the ends of bones that wears down over time, resulting in the development of osteoarthritis. The findings are published in the April issue of PLOS ONE.

To better understand the onset and progression of osteoarthritis, Nadeen Chahine, PhD, and collaborators at other institutions looked at cells from articular cartilage using atomic force microscopy (AFM). They used this technology to measure the mechanical properties of single cells to uncover what gives them integrity versus what wears them down with aging. They found in animal models that the mechanical properties of the cells are higher in adult tissue compared to young or old tissue, which is consistent with the higher loads on joints in adults than joints in infants. Furthermore, they found that vimentin, an intermediate filament (IF) protein, is a key contributor to the integrity of the cells.

"This research is exciting because we are using cutting-edge instrumentation to understand the mechanobiology of cells and cartilage, and what might cause or prevent osteoarthritis," said Nadeen Chahine, PhD, director of the Bioengineering-Biomechanics Laboratory at the Feinstein Institute. "Osteoarthritis is the most common form of arthritis, and patients who suffer from the disease experience joint pain, tenderness, stiffness and locking.

It is my hope that this and additional research into articular cartilage will provide insight into how we may be able to alleviate these disruptive symptoms of osteoarthritis through innovative research at the interface of mechanics and biology."


Contact: Emily Eng
North Shore-Long Island Jewish (LIJ) Health System

Page: 1

Related medicine news :

1. Feinstein Institute Scientist Wins Crafoord Award from Royal Swedish Academy of Sciences for Arthritis Research
2. A Feinstein Institute for Medical Research Study Shows Early Cognitive Problems among Those Who Eventually Get Alzheimer's
3. Feinstein Institute researchers discover plant derivative
4. Feinstein announces submission of new drug application for diagnosing parkinsonian syndromes
5. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
6. Feinstein Institute to Receive Grant from Centers for Medicare & Medicaid Services to Improve Schizophrenia Treatment
7. Feinstein Institute to receive grant to improve schizophrenia treatment
8. La Jolla Institutes surprising finding could alter the face of dengue vaccine development
9. Spencer Institute’s Mind Body Fitness Certification Integrates Best of Mental and Physical Training to Promote Healthy Living
10. Spencer Institute Lifestyle Fitness Coach Certification Combines Life Coaching and Fitness Coaching in One Powerful Online Training
11. MGH Neurological Clinical Research Institute and Prize4Life receive Bio-IT World award
Post Your Comments:
(Date:10/13/2017)... N.J. (PRWEB) , ... October 13, 2017 , ... The ... Holly Day Market. Featuring a collection of specialty vendors and unique items from across ... personalized and quality-focused health and wellness services offered by the VNA. The boutique ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
Breaking Medicine Technology: