Navigation Links
Feedback loop maintains basal cell population
Date:11/1/2012

HOUSTON - (Nov. 2, 2012) Notch the protein that can help determine cell fate maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein TGF beta (transforming growth factor beta), said Baylor College of Medicine researchers in the journal Cell Stem Cell.

"When basal cell homeostasis (or maintenance of a stable population) is disrupted, it may be part of the process that initiates prostate cancer," said Dr. Li Xin, assistant professor of molecular and cellular biology at BCM and a senior author of the report.

"Notch signaling takes different functions in different cell lineages," he said. "For example, Notch can suppress proliferation of basal cells and enhance it in luminal cells (another population of cells in the prostate)."

In studies in mice, Xin and his colleagues found that disrupting the Notch signal did not have much effect on the basal cells. However, when they disrupted both Notch and TGF beta signal, the basal cells begin to proliferate a lot," he said.

Notch is one of the important parts of the process by which basal cells sense the signals from TGF beta, said Xin.

While it might be tempting to suppress Notch signaling in an effort to prevent prostate cancer, it is probably not the best course. Systemic long-term inhibition of Notch can be toxic to intestines and result in vascular tumors.

"Once the important layer of basal cells is laid down in the prostate, the Notch-TGF beta feedback loop keeps the homeostasis of basal cells in the adult mouse prostate," said Xin.

"The disruption of this layer of basal cells may play a critical role in the initiation of prostate cancer," said Xin.


'/>"/>

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Glucose deprivation activates feedback loop that kills cancer cells, UCLA study shows
2. Video game with biofeedback teaches children to curb their anger
3. Liver fat gets a wake-up call that maintains blood sugar levels
4. Discovery suggests new combination therapy strategy for basal-like breast cancers
5. New drug found effective against rare form of basal cell skin cancer
6. Unique physiology key to diagnosing and treating diabetes in Asian populations
7. 53 million Americans might have diabetes by 2025, according to a new study in Population Health Management
8. One-Third of U.S. Homeless Population Is Obese: Study
9. Population displacement during disasters predicted using mobile data
10. Higher levels of public reimbursement positively influence national birth rates and reduce unmet needs in subfertile populations
11. Renal denervation treats resistant hypertension in real world patient populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Sterilizers manufacturers and is a valuable source of ... the industry. This report provides a basic overview of ... In this part, the report presents the company profile, ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... The short film “Color of Honor” by young director/producer ... true 9/11 hero, Welles Remy Crowther. It has been chosen ... of Nuremberg International Short Film Festival and the 8th International ... and director Luciana Lagana plays the mother of the ... Gregory Graham - Graham plays a heroic policeman ...
(Date:12/25/2014)... 2014 When head lice hits a home ... frenzy to get rid of it while keeping it from ... Gables now have the solution right in their neighborhood: ... Lice Troopers provides full spectrum head lice screening and treatment ... including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and ...
(Date:12/25/2014)... -- Overeating is common during the holidays, but there are ... says. "Don,t arrive at a party hungry. It may ... be attending a party, but deprivation leads to hunger, and ... Westchester Hospital in Mount Kisco, N.Y., said in a hospital ... day and even to have a snack before attending a ...
Breaking Medicine News(10 mins):Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Organisation (NACO), using better and an more improved data collection ... India are living with HIV. This clearly indicates that the ... ,Previously, in 2004 the figures complied had shown ... virus. It is estimated 38% of females and 57% male ...
... in the brain can explain why men and women ... the effects// of certain pain-relief drugs, reveals a new ... the Atlanta-based Center for Behavioral Neuroscience (CBN). ... the results highlight that similar differences occur in humans ...
... in local markets has paved for the establishment of ... chains in Hong Kong would be required to set ... to official sources. ,An operational pesticide ... Kong's food official that helped alleviate the citizens' anxiety ...
... online issue of BMC Public Health focuses on the co-relation ... and the incidence of prostate cancer (CaP).// This co-relation exists ... CaP. ,However by Dr. Leavy and colleagues did ... 2001 and 2002, 606 men with CaP from Western Australia ...
... a New Zealander says that he was forced to take dramatic ... received her medications. // He says the local DHB began trying ... take her from the hospital unless provided with the drug. ... one, which controls her nausea. The Hawke's Bay hospital refused to ...
... is one of the leading company which manufactures contact lens ... eye infections in some users. // After this ... Bausch & Lomb facilities. There was extensive microbiological testing conducted ... the culprit behind the eye infection. Bausch & Lomb stopped ...
Cached Medicine News:Health News:HIV/AIDS On The Rise In India 2Health News:Gender Difference In Pain Experience Explained By Brain Diversity 2
(Date:12/22/2014)... JUNCTION, N.J. , Dec. 22, 2014 /PRNewswire/ ... company marketing its CytoSorb® blood purification technology to ... surgery patients in 28 countries worldwide, today announced ... Russo , MD, FACS, as its Senior Vice ... Dr. Di Russo ...
(Date:12/22/2014)... --  TRU-D SmartUVC LLC, producers of the first ... that the General Services Administration has awarded the company ... This newly formed agreement will allow TRU-D SmartUVC ... including Department of Veteran Affairs and Department of Defense ... solutions for the Ebola effort in West ...
(Date:12/22/2014)... CHESTERBROOK, Pa. and STOCKHOLM ... AB (publ) (Sobi) and partner Auxilium Pharmaceuticals, Inc. today ... Use (CHMP) of the European Medicines Agency (EMA) has ... (collagenase clostridium histolyticum) for the treatment of adult men ... deformity of at least 30 degrees at the start ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... July 12, 2011 Roche (SIX: RO, ROG; ... CALP ) today announced a co-marketing ... protocols for the NimbleGen SeqCap EZ Library solution-based ... collaboration aims to simplify high throughput targeted resequencing ...
... 12, 2011 Millennium Pharmacy Systems, the leader in ... assisted living care settings, has announced a new release ... improved speed and usability as a motive, this release ... (electronic medication order entry). Enhancements to the system were ...
Cached Medicine Technology:Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 2Roche NimbleGen and Caliper Collaborate to Offer Automated Target Enrichment Pipeline Solution for Next-Generation Sequencing 3Now Faster & Easier — Millennium Pharmacy Systems Announces New Release of MPSRx® 2
... tension-free sling technology marries with ... collagen matrix sling, for exceptional ... between sling and host, reduces ... vaginal abrasion or erosion and ...
... are designed specifically for rehabilitation facilities. These ... deck that provides the ideal cushioning for ... user-friendly control panel displays all pertinent information ... features a "soft start" the belt ...
... The FineTech-Brindley (also known as the VOCARE) ... has been used by people with spinal ... urinate) on demand. A secondary use of ... evacuation and promote penile erection.,The Bladder System ...
Used for dilation of a tract to the kidney for removal of stones. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: