Navigation Links
Feedback loop explains inflammatory effect on intestinal lining
Date:3/18/2010

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a significantly higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells.

Researchers at Emory University School of Medicine have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations. The findings also suggest that interfering with one component of the feedback loopa protein called "dickkopf 1" may aid in controlling inflammatory bowel diseases.

The results are published online and scheduled for publication in the March 26, 2010 issue of the journal Immunity.

Senior author of the paper was Asma Nusrat, MD, Emory professor of pathology and laboratory medicine. The research was conducted by postdoctoral fellows Porfirio Nava, Stefan Koch and Mike Laukoetter. Laukoetter is now at the University of Mnster in Germany.

The cells lining the intestine, or intestinal epithelial cells, are normally able to repair breaks in the lining by dividing and migrating until the wound has been healed, Nusrat explains. In inflammatory bowel diseases such as Crohn's or ulcerative colitis, immune cells release signals that prevent this repair and cause epithelial cells to die.

Nusrat and her colleagues examined mice treated with a chemical, dextran sulfate, which gives them colitis. The most prominent signaling molecules given off by immune cells in inflamed intestinal tissue were the cytokines ("cell movers") interferon-gamma and tumor necrosis factor-alpha. When the researchers treated intestinal cells by themselves in dishes with these cytokines, the cells had a burst of growth but then started to die out after three days.

"We were puzzled when we saw that cytokines induced activation of a pathway that
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Allergy Relief, Chiropractic and Biofeedback Provided at New Absolute Health Clinic in Scottsdale, Arizona
2. Biofeedback Now Seen as Regular Medicine
3. VIVA Transcription Engages Satrix Solutions to Develop Customer Feedback Programs
4. Flagpole Software Introduces New Tool for User Feedback and Open Innovation
5. Innovative Biofeedback Technology Wins By A "Knockout."
6. Effect of real-time CPR feedback reported at resuscitation science symposium
7. Driven by Customer Feedback, BodyMedia, Inc. Announces Major Enhancements and Brand Change for GoWear Fit
8. Peak Performance, Neurofeedback and Biofeedback: New Frontiers of Empowerment From, and In, Sport
9. New FDA Study Seeks Feedback on Lasik Surgery
10. Guide for Using Survey Kiosks for Instant Customer Feedback Sponsored by Opinionmeter
11. Massachusetts Patients Offer Feedback on Their Experiences With Primary Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... McKinney, Texas (PRWEB) July 30, 2014 ... surgical hospital, is proud to announce the launch of ... throat (ENT), and general surgery. The doctors working in ... the needs of infants, children, and adolescents. Dr. Timothy ... Kapadia, Dr. Chad McDuffie, Dr. Neelesh Mehendale, and Dr. ...
(Date:7/30/2014)... Dialogic Inc. , the ... DollarPhone, the largest privately owned calling card platform ... ControlSwitch™ softswitch to offer enhanced session initiation ... to both its wholesale and prepaid customers. With ... to power DollarPhone’s network infrastructure, allowing the prepaid ...
(Date:7/30/2014)... A formal complaint has been ... the maker of the dialysis products GranuFlo and ... defrauded the state, its residents, physicians and dialysis ... they were recalled in 2012. There are hundreds ... pending in the U.S. District Court, District of ...
(Date:7/30/2014)... ,Middle-aged adults with a history of alcohol abuse are ... severe memory problems later in life, according to a ... could help doctors identify those at risk for memory ... "We already know there is an association between ... that understanding is based on asking older people how ...
(Date:7/30/2014)... 30, 2014 Sagacious Consultants, the premier ... $10,000 to a group of charities supporting veterans—Wounded Warrior ... Aaron Grider Foundation. This donation is part of Sagacious ... to contribute a donation every year to a charity ... their surrounding communities. , “We are thrilled to make ...
Breaking Medicine News(10 mins):Health News:Victory Medical Center Craig Ranch Debuts Pediatric Care Unit 2Health News:Victory Medical Center Craig Ranch Debuts Pediatric Care Unit 3Health News:DollarPhone Expands Prepaid and Wholesale Offerings With Enhanced Dialogic ControlSwitch 2Health News:DollarPhone Expands Prepaid and Wholesale Offerings With Enhanced Dialogic ControlSwitch 3Health News:Louisiana Attorney General Files Complaint Against GranuFlo Manufacturer, Baron and Budd Reports 2Health News:Louisiana Attorney General Files Complaint Against GranuFlo Manufacturer, Baron and Budd Reports 3Health News:Adults Who've Abused Alcohol May Be at Risk for Memory Problems 2Health News:Sagacious Consultants Supports Veterans Charities With $10,000 Donation 2
... 6-7, Mandarin Oriental, Washington, D.C., ARLINGTON, ... industry,CEOs, along with top Wall Street analysts ... other government officials, will headline the,Generic Pharmaceutical ... 2007. The conference, "Generics: Prescription for Affordable,Health ...
... ATRC ), a medical device company focused on ... David J. Drachman, President and Chief Executive Officer, is,scheduled ... at the Four Seasons Hotel in Boston on Wednesday, ... cast and recording of the presentation will be available ...
... Italian study , , THURSDAY, Aug. 30 (HealthDay News) -- Stroke ... dying in the next year compared to those who stayed ... of other studies have shown the benefits of using statins ... the Italian study comes on the heels of a Spanish ...
... have no genetic blueprint to classify melanomas, a lethal form ... deeply the growth has invaded underlying skin tissue. The ... cancer, but some patients defy the odds and survive with ... patients with cancers of the same invasion depth and appearance ...
... reduce or prevent allergic reactions, group suggests , THURSDAY, ... people with seasonal allergies may suffer oral allergy syndrome ... pollen proteins from weeds, grass and trees and similar ... symptoms of OAS -- also known as pollen-food syndrome ...
... be behind ability to know the tone of a musical ... do-it-yourself study has found evidence for a possible genetic basis ... of a musical note without other notes as reference, researchers ... sibling of a person with absolute pitch also has absolute ...
Cached Medicine News:Health News:GPhA's 2007 Annual Policy Conference Features Top Generic Industry CEOs; FDA, Government Officials; Wall Street Analysts 2Health News:AtriCure to Present at Thomas Weisel Partners 2007 Healthcare Conference 2Health News:Stopping Statins After Stroke Doubles Death Risk 2Health News:Stopping Statins After Stroke Doubles Death Risk 3Health News:Gene signature spells poor outcome 2Health News:Pollen, Fruits, Veggies Help Trigger Oral Allergy Syndrome 2Health News:Is Perfect Pitch All in the Genes? 2
(Date:7/30/2014)... , July 30, 2014  Packaging Coordinators, Inc. ... definitive agreement to acquire Penn Pharmaceutical Services Limited (Penn ... in the United Kingdom ... Hope, Pennsylvania and Tokyo ... services, including Clinical and Commercial dosage form manufacturing, as ...
(Date:7/30/2014)... 30, 2014   Medical Equipment Solutions, Corp. ... a Department of Defense (US Army) contract valued at ... mobile MRI diagnostic machine and technical support staffing. As ... the Small Business Administration (SBA), Medical Equipment is proud ... the latest medical diagnostic equipment. The SBA 8-A certification ...
(Date:7/30/2014)... 2014 Die Apex Medical Corporation ... Bereich Atemtherapie- und Druckzonenprodukte, gibt bekannt, dass ... Deutschland anfechten werden. Dieses hat entschieden, dass ... von ResMed verletze. Apex weist darauf hin, ... verschiedene Patente von ResMed Anfechtungen wegen Nichtigkeit ...
Breaking Medicine Technology:PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 2Apex setzt seinen Kampf gegen Patente für einen freien Wettbewerb fort 3
... The DNA Engine instrument is ... Unprecedented thermal uniformity and ... and block-to-block. This rugged ... cycler, it's a platform for new ...
... Start up kit. Includes configured Laptop PC ... 1 MultiBlock satellite thermal Cycler (non-robotic). ... User friendly software. Store/track run data. ... lid. Outstanding uniformity. Advanced control ...
0.2ml Gradient Block MBSR. Robot compatible block ejection mechanism. Stackable. (96 well block - holds 1 plate 0.2ml x 96 well plate)...
96 well format, Gradient features tests 12 PCR annealing temperatures in 1 run...
Medicine Products: