Navigation Links
Feedback loop explains inflammatory effect on intestinal lining
Date:3/18/2010

Signals released by immune cells during a bout of inflammatory bowel disease interfere with intestinal cells' ability to regenerate. Yet people with inflammatory bowel diseases have a significantly higher risk of developing colon cancer: a hyper-activation of growth in those same intestinal cells.

Researchers at Emory University School of Medicine have identified a feedback loop involving a growth-regulating circuit in intestinal cells, which helps explain these apparently contradictory observations. The findings also suggest that interfering with one component of the feedback loopa protein called "dickkopf 1" may aid in controlling inflammatory bowel diseases.

The results are published online and scheduled for publication in the March 26, 2010 issue of the journal Immunity.

Senior author of the paper was Asma Nusrat, MD, Emory professor of pathology and laboratory medicine. The research was conducted by postdoctoral fellows Porfirio Nava, Stefan Koch and Mike Laukoetter. Laukoetter is now at the University of Mnster in Germany.

The cells lining the intestine, or intestinal epithelial cells, are normally able to repair breaks in the lining by dividing and migrating until the wound has been healed, Nusrat explains. In inflammatory bowel diseases such as Crohn's or ulcerative colitis, immune cells release signals that prevent this repair and cause epithelial cells to die.

Nusrat and her colleagues examined mice treated with a chemical, dextran sulfate, which gives them colitis. The most prominent signaling molecules given off by immune cells in inflamed intestinal tissue were the cytokines ("cell movers") interferon-gamma and tumor necrosis factor-alpha. When the researchers treated intestinal cells by themselves in dishes with these cytokines, the cells had a burst of growth but then started to die out after three days.

"We were puzzled when we saw that cytokines induced activation of a pathway that
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Allergy Relief, Chiropractic and Biofeedback Provided at New Absolute Health Clinic in Scottsdale, Arizona
2. Biofeedback Now Seen as Regular Medicine
3. VIVA Transcription Engages Satrix Solutions to Develop Customer Feedback Programs
4. Flagpole Software Introduces New Tool for User Feedback and Open Innovation
5. Innovative Biofeedback Technology Wins By A "Knockout."
6. Effect of real-time CPR feedback reported at resuscitation science symposium
7. Driven by Customer Feedback, BodyMedia, Inc. Announces Major Enhancements and Brand Change for GoWear Fit
8. Peak Performance, Neurofeedback and Biofeedback: New Frontiers of Empowerment From, and In, Sport
9. New FDA Study Seeks Feedback on Lasik Surgery
10. Guide for Using Survey Kiosks for Instant Customer Feedback Sponsored by Opinionmeter
11. Massachusetts Patients Offer Feedback on Their Experiences With Primary Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... 29, 2015 , ... It can be uncomfortable to wear ... and sweat. "In order to prevent these problems, I conceived of my design," ... MEN'S UNDERGARMENT provides optimal support for a male’s crotch. It improves comfort for ...
(Date:8/29/2015)... ... 2015 , ... Dr. Tim Novelli, DC., Founder and President of the Patriot ... of the chiropractic field in the military. All too often VA hospitals treat patients ... made available to the VA program over a decade ago, the reality is that ...
(Date:8/29/2015)... , ... August 29, 2015 , ... Next weekend is ... summer (which astronomically, officially ends on September 22nd this year). For IT security personnel, ... hangovers linger on which could prove far more costly than a simple headache. , ...
(Date:8/29/2015)... ... August 29, 2015 , ... People who have heart ... emphysema), or asthma, are at higher risk from wildfire smoke especially in Calgary, ... or heart-rhythm problems (arrhythmia or irregular heartbeat) are also sensitive to air pollution. ...
(Date:8/29/2015)... ... , ... The popular television program VOICES IN AMERICA, hosted by legendary star ... devoting an entire short segment to the subject of diabetes. Diabetes is a debilitating ... daily basis, but recent advancements in medical science may prove to be a significant ...
Breaking Medicine News(10 mins):Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Heart Fit Clinic Sounds the Alarm on Forest Fire Smoke and Chronic Heart Disease in Calgary Area 2
... ... public outbursts of Wilson, Williams and West in regards to losses of IQ and Emotional ... ... front of millions of viewers Joe Wilson shouts "you lie, to the president, Serena Williams ...
... ... pleased to announce the formation of The Healthcare Consortium. The mission of the ... healthcare workplace to better serve patients and communities. , ... Chicago, IL (PRWEB) September 28, 2009 -- Ascension ...
... more likely to die than patients with higher incomes. That ... to be published in the December 1, 2009 issue of ... Society. The study,s findings indicate that poor prostate cancer patients ... the previous studies on socioeconomic status (SES) and prostate cancer ...
... ages, macular degeneration rates are expected to swell , SUNDAY, ... vision loss among people older than 60, age-related macular degeneration ... as the U.S. population grows older. , However, a series ... mean that eye specialists will be well-prepared to treat the ...
... Dr. ... ... shortage in Oregon will be among the topics discussed by Dr. Kristine Campbell, executive director ... Thursday, Oct. 15., , , , ,Campbell also will speak about health care policy and ...
... spider may improve erections, researchers say , FRIDAY, Sept. ... novel way to treat erectile dysfunction -- using the ... the Brazilian wandering spider (Phoneutria nigriventer) causes a painful ... lead to impotence, researchers from the United States and ...
Cached Medicine News:Health News:Outbursts: Where did Their IQ points Go and What were They Thinking? 2Health News:Outbursts: Where did Their IQ points Go and What were They Thinking? 3Health News:Outbursts: Where did Their IQ points Go and What were They Thinking? 4Health News:Ascension Health, HCA, North Shore-LIJ Health System, and Lightspeed Research -The Foresight Group announce the formation of The Healthcare Consortium 2Health News:Ascension Health, HCA, North Shore-LIJ Health System, and Lightspeed Research -The Foresight Group announce the formation of The Healthcare Consortium 3Health News:Ascension Health, HCA, North Shore-LIJ Health System, and Lightspeed Research -The Foresight Group announce the formation of The Healthcare Consortium 4Health News:Swiss study finds income affects prostate cancer patients' survival 2Health News:New Treatments Hold Hope for Failing Eyes 2Health News:New Treatments Hold Hope for Failing Eyes 3Health News:George Fox University Hosts Oregon Center for Nursing Director Oct. 15 2Health News:Spider Venom -- The Next Way to Treat Impotence? 2
(Date:8/28/2015)... ANGELES , FARUM, Denmark and ... On July 31, 2015 the US Food and ... the treatment of Major Depressive Disorder in adult patients who ... in the current episode. TMS is a non-invasive technique for ... in patients suffering from Major Depressive Disorder. The procedure has ...
(Date:8/28/2015)... The report "Eubiotics Market by Type (Probiotics, Prebiotics, Organic Acids, ... by Region ( North America , ... of the World) - Global Trends and Forecast to 2020", ... at USD 4.62 Billion in 2014 and is projected to ... 7.4% from 2015 to 2020. Browse 77 ...
(Date:8/28/2015)... , August 28, 2015 ... to reach USD 49.12 billion by 2020, growing at ... to a new report by Grand View Research, Inc. ... CAGR of 49.7% from 2014 to 2020. ... aging population along with rising incidences of chronic diseases ...
Breaking Medicine Technology:Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 3Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5
... Dissectron ultrasonic aspirator, ... ultrasonic surgical aspirator for ... of tissue available only ... Gathers in a very ...
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 7.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 8.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 8.0 mm and length 5 mm....
Medicine Products: