Navigation Links
Feed a cold -- starve a tumor
Date:10/20/2011

The condition tuberous sclerosis, due to mutation in one of two tumor suppressor genes, TSC1 or TSC2, causes the growth of non-malignant tumors throughout the body and skin. These tumors can be unsightly and cause serious damage to organs. Growth of tumors in the brain may cause seizures and in the kidney, liver or heart, tumors can disrupt normal function, to the extent of causing the organ to fail. New research published in BioMed Central's open access journal Cell and Bioscience shows that the growth of glucose-dependent TSC-related tumors can be restricted by 2-deoxyglucose, which blocks glucose metabolism, but not by restricting dietary carbohydrates.

TSC1 and TSC2 normally inhibit the mTOR signaling pathway but if the TSC genes are mutated, so that they no longer function, unregulated mTORC1 drives glycolysis and cell growth. Rapamycin works by blocking mTORC1 and is currently used to treat tuberous sclerosis. However, rapamycin is an immunosuppressant and can have significant side effects, especially when used long term. A group of researchers from the University of Washington, led by Prof Yeung, looked in detail at the potential of blocking cell proliferation by directly reducing glycolysis.

Surprisingly TSC2-negative tumors in mice kept on an unrestricted carbohydrate-free diet grew bigger than those on a western-style diet. However the glucose analogue, 2-deoxyglucose (2DG), which disrupts glucose metabolism, reduced the tumor size in mice on either diet. Prof Yeung explained, "Treatment with 2DG significantly reduced the rate at which the tumor cells divided, especially when paired with a diet which contained carbohydrates. This combination of 2DG and a western-style diet imposed the greatest energy stress on the tumors and correlated with the lowest levels of serum glucose. On the other hand, while the carbohydrate-free (and high-fat) diet provided enough free fatty acids to sustain tumor growth, some of the saturated fa
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research aims to starve breast cancer cells
2. A double block of blood vessels to starve cancerous tumors
3. A new cancer vaccine starves tumors of blood
4. More evidence that allergies may help in fighting brain tumors
5. Hispanic women have higher incidence of rare breast tumor
6. John Theurer Cancer Center hosts New Frontiers in the Management of Solid and Liquid Tumors
7. Bone marrow cells migrate to tumors and can slow their growth
8. Dioxin-like chemical messenger makes brain tumors more aggressive
9. Grant to LSUHSC Tumor Registry creates pediatric cancer research tool
10. Knockout of protein prevents colon tumor formation in mice
11. New technique identifies first events in tumor development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... July 14, 2014 Reha Technology ... a compact, portable and full-featured upper extremity robotic ... use of interactive games and challenges in a ... Occupational Therapy , Armotion combines a ... order to maximize the therapy effect for patients ...
(Date:7/14/2014)... Love Digits LLC has successfully launched ... The App brings ancient astrology to the modern dating ... compatibility using a five-star rating system. By entering their ... test their compatibility for love and marriage across seven ... five-star rating system generates a weighted average of the ...
(Date:7/14/2014)... 14, 2014 New research and analysis ... for the Earth examines toxic ingredients in tampons, ... nationwide, including specific chemicals that may be found in ... fragrances that may put women’s health at risk. ... Alexandra Scranton , the potential impact of toxic ...
(Date:7/13/2014)... Recently, MagicQuinceaneraDresses.com, a well-known special occasion dress manufacturer and ... Dama dresses . Furthermore, the company’s sales manager has ... sale. They are available at greatly discounted prices, up ... to unveil the cheap, fashionable Dama gowns. “By launching ... for our fans. It will last until July 26. ...
(Date:7/13/2014)... Manchester United and AS Roma ... International Champions Cup. The 2014 ICC is one of ... of the talent of it brings in. Teams like Real ... compete in the 2014 event spread across 10 American cities. ... game between Olympiacos and Milan and will conclude with the ...
Breaking Medicine News(10 mins):Health News:Reha Technology Launches the Armotion™, a Device for the Rehabilitation of the Upper Extremity 2Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 2Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 3Health News:New Patent Analysis Shows Toxic Risk From Tampons 2Health News:New Patent Analysis Shows Toxic Risk From Tampons 3Health News:New Patent Analysis Shows Toxic Risk From Tampons 4Health News:New Patent Analysis Shows Toxic Risk From Tampons 5Health News:Fashionable Dama Dresses Unveiled By Well-known Supplier MagicQuinceaneraDresses.com 2Health News:Manchester United vs. AS Roma Tickets in Denver, CO at Sports Authority Field at Mile High: Ticket Down Slashes Ticket Prices on International Champions Cup in Denver 2Health News:Manchester United vs. AS Roma Tickets in Denver, CO at Sports Authority Field at Mile High: Ticket Down Slashes Ticket Prices on International Champions Cup in Denver 3
... A novel drug designed to lessen muscle damage from a ... Clinical Research Institute. Results of the study, available online and ... journal Circulation, reflect the first time the drug has been ... blocks the activity of an enzyme called delta protein kinase ...
... HILL, N.C., Feb. 7 Selecting and deploying,cross- ... new,challenge for marketing leaders at pharmas and biotechs. ... similar,structure, composition, and responsibilities -- all detailed in ... Practices, LLC., According to research findings, most ...
... Research Proves Dance Dance ... Be a Tremendous Workout, SAN DIEGO, Feb. 7 ... hand controllers in favor of more,full-body interaction, the American Council ... The ACE commissioned research out of the University of ...
... Health Advocates Together to Educate ... Feb. 7 Most Americans are aware of,the dangers of ... says levels of indoor air pollution can be two to ... than outdoor air,pollution levels? Five out of 10 Americans are ...
... Videos of sports-fanatic pets sought for Mutt Madness contest, ... on to find,America,s "Ulti-mutt" Sports Pet. Video submissions and ... contest sponsored by PetFirst,Healthcare., If Fido is a ... your,football team scores or catches some serious air when ...
... already shown to improve health, can also cut total health-care ... of Washington. The study appears in the February issue of ... about 3 million older adults in the United States and ... mostly due to an increased use of medical, not mental ...
Cached Medicine News:Health News:Novel compound may lessen heart attack damage 2Health News:Pharmaceutical Product Commercialization & Governance Best Practices: Securing Talent for Highly-Effective Brand Teams 2Health News:Can a Video Game Make Your Kids More Fit? 2Health News:February is Designated as 'National Care About Your Indoor Air' Month 2Health News:February is Designated as 'National Care About Your Indoor Air' Month 3Health News:February is Designated as 'National Care About Your Indoor Air' Month 4Health News:Search Underway for America's 'Ulti-mutt' Sports Pet 2Health News:Team treatment for depression cuts medical costs 2Health News:Team treatment for depression cuts medical costs 3
(Date:7/11/2014)... 2014 /PRNewswire-iReach/ -- VAPETEK™, Inc. has announced a ... use in portable vaporizers, which contains CBD, or ... cannabis, cannabidiol offers consumers a THC-free product made ... vaporizer technology. Photo - http://photos.prnewswire.com/prnh/20140711/126344 ... different compounds which are currently known, two of ...
(Date:7/11/2014)... According to a new ... Material, Application (Healthcare, Homeland security, Industrial application, Nuclear ... Hand-Held Instruments, Fixed, and Installed Instruments) & Geography ... by MarketsandMarkets, the Scintillator Market is expected to ... to 2020, and reach $479.16 Million in 2020. ...
(Date:7/11/2014)... ALBANY, New York , July 11, 2014 /PRNewswire/ ... published by Transparency Market Research "Endoscopy Devices Market (Endoscopes, ... Analysis, Size, Share, Growth, Trends and Forecast, 2013-2019" the ... billion in 2012 and is expected to grow at ... reach an estimated value of USD 36.9 billion in ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... Merger Agreement with Tonsun International Company Limited,... -- SHENZHEN, China, Nov. 1, 2010 /PRNewswire-Asia-FirstCall/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; ...
... NICOSIA, Cyprus, Nov. 1, 2010 MedWOW.com, the global online ... the addition of its newest user-oriented tool: a Medical ... difficult and costly process to look for replacement parts for ... to streamline the search for buyers unable to find the ...
Cached Medicine Technology:Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 2Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 3Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 4Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 5Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 6Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 7Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 8Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 9Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 10Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 11Tongjitang Chinese Medicines Enters into Merger Agreement with Tonsun International Company Limited, Hanmax Investment Limited and Fosun Industrial Co., Limited 12MedWOW Adds Parts Finder Service and Enhances Business Model 2
The PC4200i is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
... rotators and agitators for continual ... set at 22C (71F) or ... (59F to 104F). Uniformity is ... bottom. Recorder is standard on ...
An enzyme-linked immuno-sorbent assay for the detection and quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
Anti Gliadin IgG Enzyme Immunosay for quantitative determination of Gliadin-IgG antibodies in serum....
Medicine Products: