Navigation Links
Feds fund study of drug that may prevent radiation injury

The Department of Defense has commissioned a nine-month study from Rice University chemists and scientists in the Texas Medical Center to determine whether a new drug based on carbon nanotubes can help prevent people from dying of acute radiation injury following radiation exposure. The new study was commissioned after preliminary tests found the drug was greater than 5,000 times more effective at reducing the effects of acute radiation injury than the most effective drugs currently available.

"More than half of those who suffer acute radiation injury die within 30 days, not from the initial radioactive particles themselves but from the devastation they cause in the immune system, the gastrointestinal tract and other parts of the body," said James Tour, Rice's Chao Professor of Chemistry, director of Rice's Carbon Nanotechnology Laboratory (CNL) and principal investigator on the grant. "Ideally, we'd like to develop a drug that can be administered within 12 hours of exposure and prevent deaths from what are currently fatal exposure doses of ionizing radiation."

The Defense Advanced Research Projects Agency (DARPA) has awarded Tour and co-principal investigators J. Conyers and Valerie Moore at the University of Texas Health Science Center at Houston (UT-Houston) and Luka Milas, Kathy Mason and Jeffrey Myers at the University of Texas M.D. Anderson Cancer Center a $540,000 grant for a nine-month study of an experimental drug that the investigators have named Nanovector Trojan Horses (NTH).

NTH is made at Rice's Chemistry Department and Carbon Nanotechnology Laboratory in the Richard E. Smalley Institute for Nanoscale Science and Technology. The drug is based on single-walled carbon nanotubes, hollow cylinders of pure carbon that are about as wide as a strand of DNA. To form NTH, Rice scientists coat nanotubes with two common food preservatives -- the antioxidant compounds butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) -- and derivatives of those compounds.

"The same properties that make BHA and BHT good food preservatives, namely their ability to scavenge free radicals, also make them good candidates for mitigating the biological affects that are induced through the initial ionizing radiation event," Tour said.

In preliminary tests at M.D. Anderson in July 2007, mice showed enhanced protection when exposed to lethal doses of ionizing radiation when they were given first-generation NTH drugs prior to exposure.

"Our preliminary results are remarkable, and that's why DARPA awarded us this grant with a very compressed timeline for delivery: nine months, which is almost unheard of for an academic study of this type," Tour said. "They are very interested in finding out whether this will work in a post-exposure delivery, and they don't want to waste any time."

Ionizing radiation is any form of radioactive particle or energy that converts an atom or molecule into an ion by altering the balance between the number of protons and electrons. In living organisms, ionization often results in the creation of free radicals -- highly reactive molecules that can wreak havoc by disrupting healthy physiological processes. These free radicals induce a cascade of deleterious biological events that cause further destruction to the organism in the days and weeks after initial radiation exposure event. NTH is designed to terminate the destructive biological cascade.

Tour said the researchers are also interested in finding out whether the new drugs can prevent the unwanted side effects that cancer patients suffer after undergoing radiation therapy.


Contact: David Ruth
Rice University

Related medicine news :

1. Study examines self-expanding plastic stents in the treatment of benign esophageal conditions
2. Amalgam Fillings Dont Affect Childrens Brain Development, Says Study in ADA Journal
3. Amalgam fillings dont affect childrens brain development, says study in ADA Journal
4. Global Health and Business Leaders Announce 36-Month Effort to Expand Malaria Control in Africa; 3.5 Million Lives Could be Saved in Five Years, Study Finds
5. From Research to Practice: Healthfitness, Eastman Chemical Company Case Study Demonstrates Real-World Health Gains and Productivity Savings
6. Study raises questions about diagnosis, medical treatment of ADHD
7. Another Study Links Western Diet to Heart, Health Risks
8. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
9. New Kaiser Permanente study fortifies caffeines link to miscarriage
10. Kaiser Permanente study shows link between caffeine and miscarriage
11. Study looks at off-label use of biliary stents
Post Your Comments:
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
(Date:6/24/2016)... Gilbert, Arizona (PRWEB) , ... June 24, 2016 ... ... Gilbert-based practice, is supporting the upcoming 2016 Miss Arizona pageant as its official ... primarily serves Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: