er that impedes progress in the biomedical sciences by prohibiting hypothesis testing in quantitative proteomics, where relationships between protein abundance and biology are sought," Paulovich said. "If a robust, economical, and widely diffused capability to measure all human proteins existed, the research community would have the collective means to assess the utility of all human proteins as biomarkers in hundreds of diseases and biological processes in the most efficient way. This would likely have a profound impact on health care costs and outcomes."
Ulrike Peters, Ph.D., an associate member of the Public Health Sciences Division, received a $4.6 million grant to identify genetic variants associated with colorectal cancer, the second leading cause of cancer death in the U.S.
"As this multi-site project will be conducted in well characterized cohorts, such as the Women's Health Initiative or the Health Professional Follow-up Study, we will also be able to examine whether environmental factors, including smoking, medications, alcohol, physical activity or diet change the risk of colorectal cancer related to these genetic variants," said Carolyn Hutter, Ph.D, a postdoctoral fellow working on this project.
"We expect our findings to enhance our understanding of the mechanisms underlying colorectal carcinogenesis. In turn, this will lead to improved prevention and treatment strategies," Peters said.
Scott Ramsey, M.D., Ph.D., an internist, health care economist and member of the Public Health Sciences Division, will lead a $4 million project to develop an infrastructure to support the "Center for Comparative Effectiveness Research in Cancer Genomics," or CANCERGEN.
"Dozens of genomic tests for cancer are coming to market without the high quality evidence that physicians and patients need to answer basic questions," said Ramsey, whose project will lay the foundation for designing research to study cancer genetic
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|SOURCE Fred Hutchinson Cancer Research Center|
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