Navigation Links
Fecal DNA methylation detects gastric and colorectal cancers

A preliminary evaluation of methylation of two gene promoters in fecal DNA showed promise as a noninvasive method to detect colorectal and gastric cancers, according to a new study published online August 21 in the Journal of the National Cancer Institute.

Because many patients are reluctant to undergo invasive tests for the detection of gastrointestinal cancers, the development of nonintrusive screening tests is desirable. Especially in cancer patients, some cells are sloughed off from the gastrointestinal tract, so small amounts of DNA from these cells present in stool samples can be examined for the presence of cancer biomarkers.

Takeshi Nagasaka, M.D., of the Department of Gastroenterological Surgery and Surgical Oncology at the Okayama University of Graduate School of Medicine, and colleagues analyzed methylation of the RASSF2 and SFRP2 gene promoters from 788 primary gastric and colorectal tissue specimens to determine whether methylation patterns could act as stage-dependent biomarkers of gastrointestinal tumorigenesis. Next, a highly-sensitive assay was developed for the detection of these methylation patterns among 296 fecal DNA specimens from patients with colorectal or gastric tumors.

Extensive methylation at these gene promoters was much more likely to be found in advanced gastric tumors and colorectal tumors than in normal tissue. Methylation markers were detected in 57% of gastric cancer patients, 75% of colorectal cancer patients, and 44% of subjects with advanced colorectal adenomas, but only 10.6% of patients with none of these cancers.

"Selection of adequate biomarkers is critical to the success of any screening methodology," the authors write. "By identifying disease-specific methylation patterns for human fecal DNA from advanced gastric and colorectal tumors, we could more accurately identify subjects at high risk for developing, or having developed, advanced tumors."

In an accompanying editorial, Steven H. Itzkowitz, M.D., of the Dr. Henry D. Janowitz Division of Gastroenterology at the Mount Sinai School of Medicine in New York, said these findings contribute to the field of noninvasive detection of gastrointestinal neoplasia and confirm that even one or two markers may be useful for fecal DNA testing.

"Because some of these cancersare hard to screen with current imaging techniques, further development of fecal DNA as a pan-detection assay for gastrointestinal tract cancers represents an intriguing and exciting new frontier," the editorialist writes.


Contact: Steve Graff
Journal of the National Cancer Institute

Related medicine news :

1. Fecal Blood Tests Effective at Spotting Colon Cancer
2. NIH panel seeks to dispel stigma associated with fecal and urinary incontinence
3. Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
4. New B-SURE Pads Are The Ideal Alternative Product To Use For Mild Fecal Incontinence - Small, Discrete, Absorbent - Order Online At
5. Flexi-Seal(R) Fecal Management System Receives 2008 Critical Care Nurse Advertising Effectiveness Award
6. Fecal incontinence and quality of life
7. Mouse model highlights histone methylation as distinguishing feature for leukemia subtypes
8. Work with fungus uncovering keys to DNA methylation
9. Rubicon Genomics Announces a Licensing Agreement With Abbott to Develop and Commercialize DNA Methylation Cancer Tests
10. New technique detects specific chromosomal damage, may indicate lung cancer risk
11. Blood protein detects lung cancer, even at earliest stage
Post Your Comments:
(Date:11/25/2015)... ... ... Today, Mothers Against Drunk Driving (MADD) learned that the number ... first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol impaired ... Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in 2014. ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When ... that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In ... She developed the patent-pending RECOVERY BRA for added comfort and support. The bra ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common symptoms ... hands, and dry skin. But many people who find their cholesterol levels and weight ... of their thyroid, especially if they don’t have any of the other symptoms. , ...
(Date:11/25/2015)... ... 2015 , ... Students and parents have something to be thankful for this ... Impact awards. California Casualty is proud to support the contest designed to ... reckless driving, the number one killer of young drivers. , Almost 1,000 entries ...
(Date:11/24/2015)... ... 2015 , ... Eric C. Seidel, DMD and Stephanie DeFilippo, ... revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology uses light energy ... dentist in Gettysburg, PA . From routine visits to cosmetic treatments, laser dentistry ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 Allergan plc (NYSE: AGN ) ... New York State Attorney General,s Office ... Act, and other statutes with the Attorney General over the ... cease marketing and selling the now generic version of memantine ... no liability, has released its counterclaims against New ...
(Date:11/25/2015)... 2015 USP 800 applies to all ... pharmacists, pharmacy technicians, nurses, physicians, physician assistants, home ... also covers all entities which store, prepare, transport, ... healthcare institutions, patient treatment clinics, physicians, practice facilities, ... --> What is the purpose of ...
(Date:11/25/2015)... - Will Also Offer Point -of- ... --> - Will Also Offer Point ... --> - Will Also Offer ... (CME) Elsevier , a world-leading provider of ... diagnostic imaging textbooks and decision support tools, as well as prominent ...
Breaking Medicine Technology: