Navigation Links
Fecal Blood Tests Effective at Spotting Colon Cancer
Date:9/25/2007

But they are underused, experts say

TUESDAY, Sept. 25 (HealthDay News) -- A new generation of fecal blood tests can screen for colon cancer with unprecedented accuracy, researchers report.

But the tests, although easily available, are greatly underused, said study author Dr. James Allison, an investigator with the Kaiser Permanente division of research in Oakland, Calif.

"A lot of gastroenterologists think that colonoscopy is the only test for colon cancer," Allison said.

But colonoscopy is also expensive, uncomfortable and carries the risk of damage such as internal bleeding, he said. A simple fecal occult blood test, costing less than $30 and done in minutes, can single out that small percentage of the general population that would benefit from colonoscopy, Allison said.

The study is published in the Sept. 25 issue of the Journal of the National Cancer Institute.

At least 10 fecal occult blood tests have been approved by the U.S. Food and Drug Administration, Allison said. The most widely used is Hemoccult, which has been shown in controlled trials to reduce mortality from colorectal cancer.

The two tests described in the new journal report use different methods to detect hidden blood. "Each one has different pluses and minuses," Allison said. "We need to find out which is best -- which we should be using in the United States and elsewhere."

One of the tests described in the journal report uses guaiac, the chemical in Hemoccult, as a detector. The other uses an immunochemical method. Screening of 5,841 people showed the immunochemical test to have a sensitivity of 81.8 percent, meaning that it detected that percentage of colorectal cancers and polyps. And it had a specificity -- the ability to determine which people did not have the conditions -- of 96.9 percent. The guaiac test was 64.3 percent sensitive and 90.1 percent specific.

Allison has been conducting something of a crusade to promote use of fecal occult blood tests to screen for colorectal cancer. "I am doing a tour of the United States and talking to primary-care physicians," he said.

Use of the tests not only saves lives but also reduces incidence of colorectal cancer by permitting removal of precancerous polyps, said Jack Mandel, chairman of the department of epidemiology at Emory University, who wrote an accompanying editorial in the journal.

"We did the first large study at the University of Minnesota in 1993 to show that fecal blood testing reduces mortality," Mandel said. "There were 50,000 people in that trial. Two years later, we showed that testing reduced the incidence of colorectal cancer."

Robert Smith, director of cancer screening for the American Cancer Society, said, "We recommend both guaiac-based tests and immunochemical tests. We recommend them for all adults age 50 and over."

No preference between the two methods is stated, because "at the time our last guidelines were updated, there was no clear advantage of one over another," Smith said.

"The challenge has been to get folks to use them, in particular to get doctors to adopt them in the office," he said.

More information

To learn more about colorectal cancer screening, visit the U.S. National Cancer Institute.



SOURCES: James Allison, M.D., investigator, Kaiser Permanente division of research, Oakland, Calif.; Jack Mandel, Ph.D., chairman of epidemiology, Emory University, Atlanta; Robert Smith, Ph.D., director of cancer screening, American Cancer Society, Atlanta; Sept. 25, 2007, Journal of the National Cancer Institute


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Is Prior Testing Necessary For Diagnosis And Treatment Of Fecal Incontinence (FI) ?
2. Fecal Bacteria, a Source of Contamination
3. Recommendations for Treatment of Blood Pressue
4. Blood Cells Capable of Regenerating Liver
5. Infant receives first bloodless liver transplant
6. Spouses and other partners lower blood pressure says new research
7. H2O - a cure for low blood pressure
8. Uncontrolled blood pressure
9. Weight and Blood Pressure
10. Grandmother’s diet in pregnancy can affect grandchildren’s blood sugr
11. Early diagnosis for autism from blood tests may be possible
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... as one of the best small businesses for new dads by Fatherly, the digital ... businesses providing progressive benefits to new parents on the organization’s 2016 Best Places ...
(Date:5/27/2016)... ... ... This campaign aims to provide a path to improved education and awareness ... change. , As nearly 795,000 Americans suffering from a new or recurrent stoke each ... an estimated 129,000 of these people dying from stroke, it’s become our nation’s fifth-leading ...
(Date:5/27/2016)... Texas (PRWEB) , ... May 27, 2016 , ... ... satisfying Army body fat composition regulations. This is the first time that Coolsculpting ... normally screened at least every six months to ensure they meet the prescribed body-fat ...
(Date:5/27/2016)... ... 2016 , ... Each year Standard Process Inc. ... this year’s Life University winner of a $2,500 scholarship from Standard ... Awards ceremony. , Outerbridge is approaching her last quarter at Life University in ...
(Date:5/26/2016)... ... 26, 2016 , ... There are many ways to cook a hot dog, ... that Americans prefer their dogs straight off the grill. Of the 90 percent of ... way to cook a hot dog, far outpacing other cooking methods such as steaming ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... and Orphan Diseases, today announced that President & CEO Gerald ... SeeThru Equity MicroCap Conference   Where: ... , NY When: Tuesday, May 31 st , ... Where: Grand Hyatt Hotel, 109 East 42 nd St, ...
(Date:5/26/2016)... 2016   Change Healthcare , a ... solutions and technology-enabled services designed to enable ... a strategic channel partnership with SourceMed, the ... and revenue cycle management services that empower ... clinics to optimize revenue, operational efficiency and ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
Breaking Medicine Technology: