Navigation Links
Faulty 'wiring' in the brain triggers onset of schizophrenia
Date:10/26/2009

A new study by researchers at the Institute of Psychiatry (IoP), King's College London has discovered abnormalities in the white matter of the brain that seem to be critical for the timing of schizophrenia. The study, led by Professor Phillip McGuire and Dr Sophia Frangou, has been published in this month's edition of the British Journal of Psychiatry.

The white matter of the brain consists of nerve fibres that connect parts of the brain and help regulate behaviour. The normal brain develops in a back to front fashion, i.e. posterior regions mature first and the frontal lobes last. The research discovered that if there are very severe deficits in the white matter in these posterior (specifically parietal) regions, then schizophrenia develops early in adolescence. As people grow older their deficits "migrate" in a back to front manner and in adulthood, they impact the frontal lobes of the brain quite dramatically.

Schizophrenia is a disabling and emotionally devastating illness that affects about one per cent of the population worldwide. Professor McGuire, from the NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and IoP comments: 'Although we can trace the origins of schizophrenia to early brain development we still do not know what triggers the onset of the full blown symptoms. Our study suggests that at least part of the answer lies in problems affecting the "wiring" of key brain areas.'

The team used Diffusion Tensor Imaging, a state-of-the-art neuro-imaging technique, to examine white matter connections in adolescents and adults with schizophrenia. Abnormalities in white matter appeared first in posterior parts of the brain in the younger patients and became more prominent in the frontal lobes in adult patients. In interpreting the results, Dr. Kyriakopoulos, the lead author, explained that the scans capture the interaction between brain development and disease mechanisms.

Dr Frangou on the value of this research: 'We believe this study is unique as it approaches schizophrenia research from a new perspective. It takes a life-long view on schizophrenia and thereby bridges traditional barriers between child and adult patients.'

The study adds new insight to mounting evidence that abnormalities in white matter play a critical role in what turns schizophrenia on and may provide clues to new treatments.


'/>"/>

Contact: Melanie Haberstroh
melanie.haberstroh@kcl.ac.uk
44-207-848-3076
King's College London
Source:Eurekalert

Related medicine news :

1. Pedophilia may be the result of faulty brain wiring
2. St. Jude finds mechanism for faulty protein disposal
3. St. Jude Finds Mechanism for Faulty Protein Disposal
4. Faulty brain connections may be responsible for social impairments in autism
5. Faulty DNA repair could be a risk factor for lung cancer in nonsmokers
6. Faulty Household Wiring Can Trigger a Heart Defibrillator
7. Chronic Pain Harms Brains Wiring
8. Beaumont Sees Results in Nations 1st Urinary Nerve Rewiring Surgeries for Spina Bifida Patients
9. Chronic Exposure to Solvents Disturbs Brains Wiring
10. Protein Key to Brain Rewiring
11. Wiring in the brain influences personality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Back Pain Centers of ... pain with a reputable physician in their area, announces the launch of a new ... for patients who are looking for reputable physicians to help them with back or ...
(Date:4/25/2017)... NJ (PRWEB) , ... April 25, 2017 , ... Saad B. Chaudhary, MD is committed ... treatment of acute or chronic problems, I focus on preventative care with all my patients ... you have any questions, always feel free to contact my office and my trained staff ...
(Date:4/25/2017)... ... 25, 2017 , ... Emergency Physician and Distinguished Professor of Emergency Medicine Bentley ... in Writing, set to publish in summer 2017. , Dr. Bobrow, MD, FACEP, ... Arizona College of Medicine. He also serves as Medical Director for the Bureau of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol ... is introducing Flexadin UCII, part of the EQUISTRO line, at this week’s Rolex ... in horses at the immunologic level. , The scientifically-developed Flexadin UCII supports the ...
(Date:4/24/2017)... ... April 24, 2017 , ... Emmanuel College ... nursing professionals advance their careers. Beginning in the fall of 2017, Emmanuel’s program will ... in as few as 16 months and for as little as $14,528. These changes ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... YORK , April 19, 2017 Global ... drainage devices are tubes used to remove excess liquid ... blood, serum, pus, urine, bile or lymph. Surgical drains ... of surgery such as orthopedics surgery, cardiovascular surgery, neurosurgery, ... is prophylactic post-surgery to prevent accumulation of fluid e.g. ...
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
Breaking Medicine Technology: