Fatty liver linked to increased risk of diabetic kidn... (s possibly through the release of some p...)

Fatty liver linked to increased risk of diabetic kidney disease

Date:5/29/2008

s, possibly through the release of some pathogenic factors from the liver," according to Drs. Targher and Chonchol. For example, the fatty liver might release certain substances that promote inflammation, thus contributing to diabetic kidney damage.

Diabetic nephropathy, or kidney disease, is a major complication of diabetes that can lead to end-stage renal disease (ESRD)permanent loss of kidney function requiring dialysis or transplantation. "The treatment of earlier stages of nephropathy in diabetes is effective in slowing the progression toward ESRD," Drs Targher and Chonchol note. "Thus the early detection of precursors and risk factors of CKD is very important."

If confirmed by further research, the association between NAFLD and CKD may aid in identifying diabetic patients at increased risk of kidney disease. With intensive treatment, it might be possible to prevent or delay the development of CKD in these patients.

The authors point out some limitations of their study, including the use of an estimated measure of kidney function. Also, the presence of NAFLD was assessed by liver ultrasound, without biopsy to confirm the diagnosis. Further study is needed to determine whether fatty liver is linked to an increased risk of CKD in patients without diabetes and in nonwhite patients.

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Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

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