Navigation Links
Fatheads: How neurons protect themselves against excess fat
Date:4/8/2013

We're all fatheads. That is, our brain cells are packed with fat molecules, more of them than almost any other cell type. Still, if the brain cells' fat content gets too high, they'll be in trouble. In a recent study in mice, researchers at Johns Hopkins pinpointed an enzyme that keeps neurons' fat levels under control, and may be implicated in human neurological diseases. Their findings are published in the May 2013 issue of Molecular and Cellular Biology.

"There are known connections between problems with how the body's cells process fats and neurodegenerative diseases such as Alzheimer's, Parkinson's and amyotrophic lateral sclerosis," says Michael Wolfgang, Ph.D., an assistant professor in the Department of Biological Chemistry at the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "Now we've taken a step toward better understanding that connection by identifying an enzyme that lets neurons get rid of excess fat that would otherwise be toxic."

Wolfgang says one clue to the reason for the neurodegeneration/fat-processing connection is that neurons, unlike most cells in the body, seemingly can't break down fats for energy. Instead, brain cells use fats for tasks such as building cell membranes and communicating information. At the same time, he says, they must prevent the buildup of unneeded fats. Neurons' fat-loss strategy is rooted in the fact that a fat molecule attached to a chemical group called coenzyme A will be trapped inside the cell, while the coenzyme A-free version can easily cross the cell membrane and escape. With this in mind, Wolfgang, along with colleagues Jessica Ellis, Ph.D., and G. William Wong, Ph.D., focused their study on an enzyme, called ACOT7, which is plentiful in the brain and lops coenzyme A off of certain fat molecules.

The team created mice with a non-working gene for ACOT7 and compared them with normal mice. The scientists saw no obvious differences between t
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
2. Neurons that control overeating also drive appetite for cocaine
3. Neurons derived from cord blood cells may represent new therapeutic option
4. Protein build-up leads to neurons misfiring
5. Improper protein digestion in neurons identified as a cause of familial Parkinsons
6. Difficulty in recognizing faces in autism linked to performance in a group of neurons
7. Positive stress helps protect eye from glaucoma
8. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
9. Will women use microbicides to protect themselves against HIV?
10. Physicians call for improvements to countrys public health system to protect US residents
11. Vitamin E in diet protects against many cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 30, 2014 Volunteers from the Church ... drug abuse this summer with massive distribution of ... can find these volunteers on Strøget, the famous Copenhagen ... for its shopping and its ambiance, some quarter of ... typical summer day. , These activities are part ...
(Date:7/30/2014)... Visitors to our region recognize how ... ensure its protection. Bob Kiesendahl, one of the owners ... Delaware Highlands Conservancy for donations collected through participation in ... add up fast, as visitors welcome the opportunity to ... Region. , The Kiesendahl family has owned Woodloch Resort ...
(Date:7/30/2014)... 2014. A new network of 25 regional stroke centers ... (NIH StrokeNet) is working to change the way ... advances of the last two decades, stroke remains a ... or disability for 795,000 Americans. The numbers are expected ... , To accelerate the pace of progress, NIH ...
(Date:7/30/2014)... LTC Consumer, an independent, free online service ... features an Instant Quote tool on its website, LTCconsumer.com ... Consumer. Quotes are free and unlimited. , The Instant ... areas – including age, gender, and state of residence – ... don’t need to enter any contact information to get started). ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 The Institute ... is pleased to announce that Arianna Huffington has joined as ... of the Health Coach Training Program . , Arianna ... Post, a world-renowned news and blogging site that won a ... author of fourteen books and was included on the Forbes ...
Breaking Medicine News(10 mins):Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Kessler funded as satellite site for NIH Stroke Trials Network 2Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3
... , WESTMINSTER, Colo., Dec. 7 ... change to the Noise Reduction Rating (NRR) for hearing protection ... recommendations to the United States Environmental Protection Agency (EPA). Based ... to improve the utility of hearing protection devices for occupational ...
... Advisory articles are posted on the ... 7 All Pennsylvania registered nurses can receive continuing education hours ... that are posted on the Pennsylvania State Nurses Association (PSNA) web ... to have 30 hours of continuing education every two years for ...
... a history of delinquency in childhood are more likely to die ... just from the obvious consequences of antisocial behaviour, new research indicates. ... the Journal of Public Health , is the first to ... as parental factors, affect various health outcomes 40 years later. ...
... ... experienced dentist is a crucial step in preserving your smile and dental health. , ... Minneapolis, MN (PRWEB) December 7, 2009 ... and inconvenience of emergency dental procedures. Whether a tooth is cracked, loosened, or knocked out, ...
... more complicated testing, expert says, , MONDAY, Dec. 7 (HealthDay ... detect whether a child has obstructive sleep apnea, U.S. researchers ... costly and inconvenient sleep studies in children who snore, only ... or obstructive sleep apnea, Dr. David Gozal, a professor and ...
... , ATLANTA, ... antiepileptic drug (AED) Vimpat® that offer additional clinical evidence supporting ... patients with partial-onset seizures. Results of presented research demonstrate ... up to three years, and a consistent long-term tolerability profile. ...
Cached Medicine News:Health News:NHCA Recommendations to EPA on NRR Change Intend to Improve Utility of Hearing Protection Devices at Work and at Home 2Health News:NHCA Recommendations to EPA on NRR Change Intend to Improve Utility of Hearing Protection Devices at Work and at Home 3Health News:PA Registered Nurses Can Earn Continuing Education Hours Through Pennsylvania Patient Safety Advisories 2Health News:Delinquent boys at increased risk of premature death and disability by middle age 2Health News:Delinquent boys at increased risk of premature death and disability by middle age 3Health News:Minneapolis Dentists, Shamblott Family Dentistry, Ease the Pain and Cost of Emergency Dental Procedures 2Health News:Urine Sample May Reveal Sleep Disorder in Kids 2Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 2Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 3Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 4Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 5Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 6Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 7Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 8Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 9Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 10Health News:New Data Support Long-term Use of Antiepileptic Drug Vimpat(R) (Lacosamide) (C-V) 11
(Date:7/30/2014)... Silicon Valley Bank, the bank of the ... that examines the merger, acquisition and IPO activity of ... the annual report based on 2013 data, venture investment ... started tracking the data in 2005. "2013 ... healthcare M&A activity over the last few years, the ...
(Date:7/30/2014)... NEW YORK , July 30, 2014 /PRNewswire/ ... new products for oncology supportive care, announced that its ... been featured in an article on OncLive.com titled, "Study ... and Neck Cancers."  Dr. Steve Sonis , a ... growing demand seen in the oncology community for evidence-based ...
(Date:7/30/2014)... 30, 2014   Medical Equipment Solutions, Corp. ... a Department of Defense (US Army) contract valued at ... mobile MRI diagnostic machine and technical support staffing. As ... the Small Business Administration (SBA), Medical Equipment is proud ... the latest medical diagnostic equipment. The SBA 8-A certification ...
Breaking Medicine Technology:Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2
... Spain and PHILADELPHIA, May 15, 2012 Cloud-based ... With its 4 th Annual Global Customer Summit ... growth of cloud-based Veeva CRM throughout the continent. Since Veeva,s ... delivered the advantages of cloud computing to more than 35 ...
... 2012 Surgical Information Systems ("SIS"), a leader ... clients demonstrating outstanding leadership in achieving clinical, financial, ... at SIS Congress, the company,s annual client conference, ... to five hospital systems exemplifying the innovative use ...
Cached Medicine Technology:Veeva Systems Announces Dramatic Growth in Europe 2Veeva Systems Announces Dramatic Growth in Europe 3Veeva Systems Announces Dramatic Growth in Europe 4Surgical Information Systems Recognizes Clients for Financial, Clinical, and Operational Improvements 2Surgical Information Systems Recognizes Clients for Financial, Clinical, and Operational Improvements 3Surgical Information Systems Recognizes Clients for Financial, Clinical, and Operational Improvements 4
The Perfect Single basic Vac Manifold is used to process a single 96-well plate; processing time is approximately 30 minutes....
The Perfect Vac Quad Manifold allows one to four 96-well plates to be processed simultaneously. A single plate may be processed in 30 minutes; four plates are processed in 45 minutes....
... and Nitrogen Blow-Down Evaporators. For over ten years TurboVap concentration technology has received enormous acclaim with over ... ... ... ...
... The TurboVap Concentration Workstations from Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down ... use around the world today. ... ... ...
Medicine Products: