Navigation Links
Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Date:6/19/2013

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.

More importantly, the research reveals a novel potential source of cells for regenerating damaged heart muscle, according to principal investigator Neil Chi, MD, PhD, assistant professor of medicine in the Division of Cardiology and member of the Institute of Genomic Medicine at UC San Diego.

Heart failure remains the leading cause of death in the developed world, largely due to the inability of mammalian hearts to regenerate new cells and repair themselves. However, lower vertebrates such as zebrafish are capable of generating new ventricular heart muscle cells, or cardiomyocytes, that can replace the heart muscle lost through ischemia-induced infarcts more commonly known in humans as heart attacks.

In this study, the scientists generated a genetic ablation system in zebrafish capable of targeted destruction of heart muscle, and then tracked both atrial and ventricular cardiomyocytes during injury using fluorescent proteins.

Using a genetic fate mapping technique a method of comparing cells at various points of development in order to understand their cellular embryonic origin the scientists revealed that cardiomyocytes in the heart's atrium can turn into ventricular cardiomyocyctes in a process called transdifferentiation. This transdifferentiation allows the atrial cells to regenerate and repair the ventricle, which is the chamber primarily affected in heart attacks.

First author Ruilin Zhang noted that such transdifferentiation was blocked when Notch signaling was inhibited, and subsequent studies will look at the Notch signaling pathway to understand the underlying mechanism at work.

"This is among the first studies to look at these specific cardiac lineages in detail to see how zebrafish are able to regenerate heart cells," said Chi, adding that their findings open a door to revealing how such regeneration might someday work to change the fate of human hearts.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Even Mild Depression, Anxiety Hurts the Heart: Study
2. Electronic Cigarettes Have Slight Impact on Heart: Study
3. Capture His Heart: Review of Claire Casey And Michael Fiore's Course Released
4. Heart: Cardiac PET/MR measures up to PET/CT
5. NIH awards $20 million over 5 years to train next generation of global health researchers
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
8. Researchers Find Gene Mutations That May Be a Key to Autism
9. Researchers find evidence of banned antibiotics in poultry products
10. NJ stroke researchers report advances in spatial neglect research at AAN Conference
11. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... ZirMed Inc ., a recognized leader in cloud-based revenue cycle ... ranked #1 by its users for the seventh consecutive year ... ZirMed was recognized as the top-ranked end-to-end revenue cycle management ... 200 beds and holds one of the longest #1 ranking ... ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis ... global supply chains, has published the first annual edition of its Global ... more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that ... ... Risk & Performance Index ...
Breaking Medicine Technology: