Navigation Links
Fate of the heart: Researchers track cellular events leading to cardiac regeneration
Date:6/19/2013

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought.

More importantly, the research reveals a novel potential source of cells for regenerating damaged heart muscle, according to principal investigator Neil Chi, MD, PhD, assistant professor of medicine in the Division of Cardiology and member of the Institute of Genomic Medicine at UC San Diego.

Heart failure remains the leading cause of death in the developed world, largely due to the inability of mammalian hearts to regenerate new cells and repair themselves. However, lower vertebrates such as zebrafish are capable of generating new ventricular heart muscle cells, or cardiomyocytes, that can replace the heart muscle lost through ischemia-induced infarcts more commonly known in humans as heart attacks.

In this study, the scientists generated a genetic ablation system in zebrafish capable of targeted destruction of heart muscle, and then tracked both atrial and ventricular cardiomyocytes during injury using fluorescent proteins.

Using a genetic fate mapping technique a method of comparing cells at various points of development in order to understand their cellular embryonic origin the scientists revealed that cardiomyocytes in the heart's atrium can turn into ventricular cardiomyocyctes in a process called transdifferentiation. This transdifferentiation allows the atrial cells to regenerate and repair the ventricle, which is the chamber primarily affected in heart attacks.

First author Ruilin Zhang noted that such transdifferentiation was blocked when Notch signaling was inhibited, and subsequent studies will look at the Notch signaling pathway to understand the underlying mechanism at work.

"This is among the first studies to look at these specific cardiac lineages in detail to see how zebrafish are able to regenerate heart cells," said Chi, adding that their findings open a door to revealing how such regeneration might someday work to change the fate of human hearts.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Even Mild Depression, Anxiety Hurts the Heart: Study
2. Electronic Cigarettes Have Slight Impact on Heart: Study
3. Capture His Heart: Review of Claire Casey And Michael Fiore's Course Released
4. Heart: Cardiac PET/MR measures up to PET/CT
5. NIH awards $20 million over 5 years to train next generation of global health researchers
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
8. Researchers Find Gene Mutations That May Be a Key to Autism
9. Researchers find evidence of banned antibiotics in poultry products
10. NJ stroke researchers report advances in spatial neglect research at AAN Conference
11. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... Thomas Jefferson ... Witness , was awarded a $300,000 grant from The Pew Center for Arts ... with ambiguity and the recognition of one’s own limits among health professions students. ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... $5,000 grant from the C. R. Bard Foundation, Inc. to support ... Hills , a service available through the nonprofit home care agency. Using evidence-based ...
(Date:7/21/2017)... ... 21, 2017 , ... In the first prospective ACL reconstruction ... Outcome Network (MOON) demonstrated that patients could perform sports-related functions and maintain a ... over time. The study, presented today at the American Orthopaedic Society for ...
(Date:7/20/2017)... MA (PRWEB) , ... July 20, 2017 , ... ... form of blood and bone marrow cancer that progresses rapidly without treatment. Newly ... recommended to reduce the chance of reoccurrence and relapse. With such a ...
(Date:7/20/2017)... ATLANTA, Ga. (PRWEB) , ... July 20, 2017 , ... ... and equal access to medicine for everyone affected by diabetes, is teaming up with ... the five-day global event kicks off on July 24th. , “Team Type 1’s ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)...  Mako Medical Laboratories partnered with Secretary Strickland, the ... Fund (MFA) to bring 140 soldiers back home to ... families one last time before being deployed. Mako Medical ... logistics needed for these soldiers. "Mako Medical Laboratories is ... We just wish we could bring them all home," ...
(Date:7/13/2017)...  Centurion Medical Products, a leader in medical product innovation and ... removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part of a ... pain while preventing unneeded emergency department admission due to severe fecal ...
(Date:7/11/2017)... , July 11, 2017 Zymo Research Corp., also known ... that can quantify biological aging in a precise manner using the myDNAge ... Steve Horvath , a professor of human genetics and biostatistics at the ... School of Public Health , Zymo Research,s proprietary DNAge ™ technology ... ...
Breaking Medicine Technology: