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Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration
Date:7/1/2009

LA JOLLA, Calif., July 1 /PRNewswire/ -- Fate Therapeutics, Inc. announced today that it has acquired exclusive intellectual property rights covering small molecule compositions and methods for inducing bone formation from The Regents of the University of California. These proprietary osteogenic agents were developed by Farhad Parhami, Ph.D., professor of medicine at University of California, Los Angeles, in collaboration with Michael Jung, Ph.D., professor of chemistry and biochemistry, and have been shown in vivo to exhibit osteo-regenerative activity. While many current medications aimed at addressing bone deficiencies work by preventing further decay, osteogenic agents stimulate positive bone growth and may offer an improved course of action in orthopedic medicine ranging from bone fractures to osteoporosis. The exclusive rights acquired today by Fate Therapeutics continue to bolster the Company's platform of Stem Cell Modulators (SCMs) - small molecules and biologics that seek to modulate adult stem cells within the body to guide cell fate for therapeutic purposes.

"Dr. Parhami and his research team have not only advanced the understanding of the biology around bone formation but also identified and created small molecules that may be used to induce the differentiation of adult stem cells in the body for osteo-regenerative medicine," said Paul Grayson, president and CEO of Fate Therapeutics. "The potential of these novel small molecules has been confirmed in several different in vivo proof of concept studies, and we look forward to their continued preclinical development for bone generation."

Adult stem cells are naturally-occurring cells found in almost all tissues or organs in the body and are primarily responsible for maintaining and repairing their native tissue. For example, mesenchymal stem cells are multipo
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