Navigation Links
Fat transforms vitamin C from 'good cop' into 'bad cop'
Date:9/3/2007

Fat in the stomach may cause vitamin C to promote, rather than prevent, the formation of certain cancer causing chemicals, reveals research published ahead of print in the journal Gut.

The researchers analysed the impact of both fat (lipid) and vitamin C (ascorbic acid) on nitrite chemistry in the upper (proximal) stomach, which is especially vulnerable to pre-cancerous changes and tumour growth.

Nitrites, which are present in human saliva, and in certain preserved foodstuffs, may be converted to cancer causing compounds called nitrosamines.

Nitrosamines are formed in acidic conditions, such as those afforded by stomach acid, but vitamin C inhibits their formation, by converting nitrite to nitric oxide.

The researchers replicated the chemical conditions of the proximal stomach and measured the formation of nitrosamines, oxygen, and nitric oxide.

Without fat, vitamin C curbed the levels of two nitrosamines by a factor of between five and 1000. And it completely eliminated the production of the other two.

But when 10% fat was added, vitamin C actually boosted the production of nitrosamines between 8 and 140-fold.

Fat remains in the proximal stomach for some time after a meal and also makes up a substantial amount of the cells lining the stomach, say the authors.

Nitric oxide is formed when vitamin C reacts with nitrite in acid. However, the nitric oxide can diffuse into fat and then react with oxygen to form nitrosoamine generating chemicals.

The findings may be relevant to the recent observations that vitamin C supplements fail to reduce cancer risk, say the authors.


'/>"/>
Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ Specialty Journals
Source:Eurekalert

Page: 1

Related medicine news :

1. Transformed Transforms Physician Centered Practice To Patient Centered One
2. Vitamin B12 can help in detecting cancers
3. Vitamins-The answer to Heart Disease?
4. Vitamin E, the latest warrior against diabetes
5. Vitamin Shields Brittle Bones
6. Beer vitamin protects heart
7. B Vitamin protects and lowers toxicity of Arthritis Drug
8. B Vitamin Supplementatoin Saves Money and Lives
9. Eat Vitamin C and stay young
10. Vitamin C for the heart
11. Vitamin B for Hepatitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... , ... July 24, 2017 , ... ... office at 2307 Bellmore Avenue, Bellmore, New York, (516) 784-5858. The office opened ... M.D. and physician assistants Lori Friedman and Fruma Leah Wiederman. , Advanced ...
(Date:7/24/2017)... ... 24, 2017 , ... “Nana Nana Boo Boo”: a delightful tale of a ... “Nana Nana Boo Boo” is the creation of published author Michael Rush, a Deputy ... Faith Publishing, Michael Rush’s new book presents the importance of manners in a way ...
(Date:7/24/2017)... ... ... “Journey to the Light: The Quest for Happiness and Love. . . through Faith”: ... “Journey to the Light: The Quest for Happiness and Love. . . through ... manuals, and articles, who has recently decided to expand her literary horizons and write ...
(Date:7/23/2017)... Alexandria, Virginia (PRWEB) , ... July 24, 2017 ... ... during the American Association of Physicists in Medicine (AAPM) 59th Annual Meeting & ... , Members of the medical physics profession, hospital administrators and journalists can visit ...
(Date:7/23/2017)... ... July 23, 2017 , ... A 20-year-long study by a national ... the Minneapolis Veterans Administration Health Care System overwhelmingly supports growing evidence that prostate cancer ... benefits. , In the cases involved with this study, surgery did not prolong ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... 10, 2017  The tenth annual BioPharm America™ ... at the Sheraton Boston Hotel, September 26–27. ... to global decision makers and innovative biotech startup companies. ... leaders during two impactful days. BioPharm America is now ... additional networking opportunities with 4,500+ life science industry influencers ...
(Date:7/5/2017)... 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... ), a clinical-stage pharmaceutical company focused on the development of ... approval from the Israel Securities Authority to dual-list its common ... stock will commence trading on the TASE on July 12, ... capitalization of the Company, it is expected that Oramed will ...
(Date:6/30/2017)... ROCKVILLE, Md. , June 30, 2017 ... that since the start of May, at least ten ... financings include private investments, public offerings and a loan ... $3.3 million to almost $80 million.  Kalorama Information provides ... customers of its Diagnostics Knowledge Center. ...
Breaking Medicine Technology: