Navigation Links
Fat on chest and upper back increases risk of insulin resistance
Date:8/17/2007

Upper trunk fat deposits of fat on the chest and back is associated with an increased risk of insulin resistance, a condition that is a precursor of type 2 diabetes, according to a study led by researchers at the San Francisco VA Medical Center (SFVAMC).

It is the first time such an association has been demonstrated, say the researchers.

The association was equally strong in both HIV infected subjects and HIV negative control subjects in the Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM), a national long-term longitudinal study of HIV infected people taking modern antiretroviral therapy and HIV negative controls.

The presence of visceral fat, which is located between and around the internal organs, was also associated with an increased risk of insulin resistance in both populations. The researchers found that each type of fat contributes independently to insulin resistance whether or not the other type is present.

The study appears in online Publish Ahead of Print section (http://www.jaids.com/pt/re/jaids/paptoc.htm) of the Journal of Acquired Immune Deficiency Syndromes.

We knew about the insulin resistance risk associated with visceral fat, which has been shown in previous studies, but no one had ever looked at the contribution of upper trunk fat, says lead author and FRAM principal investigator Carl Grunfeld, MD, PhD, chief of the metabolism and endocrine sections at SFVAMC. Strikingly, there was very little difference between HIV infected people and controls. If you have fat up top, its bad for you.

In insulin resistance, cells in the body become increasingly resistant to the action of insulin, a hormone that regulates blood glucose levels. The result is chronically high blood glucose, which has many adverse health effects.

The researchers measured visceral and subcutaneous fat deposits in the legs, arms, upper trunk, and lower trunk of 926 HIV infected subjects and 258 HIV negative controls. They divided each population into tertiles, or thirds, based on the amount of fat in each location. Among the HIV infected subjects in the highest tertile of upper trunk fat, 57 percent showed insulin resistance; of those, half lacked high visceral fat. Among the highest tertile of controls with upper trunk fat, 61 percent were insulin resistant. A third of that group did not have high visceral fat.

So, basically, there are people who have a lot of fat in their upper trunk and not so much inside their belly, yet they are at risk for insulin resistance, observes Grunfeld, who is also a professor of medicine at the University of California, San Francisco (UCSF). And there are people with a lot of visceral fat but not upper trunk fat who are in the same boat. But if youve got both, its a double whammy. Your risk of insulin resistance is quite high.

Grunfeld says that the researchers looked at all regions of the body where fat is usually deposited in order to investigate abnormalities in fat distribution that have been reported in HIV infection, particularly the presence of so-called buffalo hump, a prominent fat deposit in the middle of the upper back. But we found that fat in that area was present, and associated with the same risk for insulin resistance, in both HIV infected and control subjects, he says.

Grunfeld explains the lack of difference in risk between HIV infected and HIV negative subjects by noting that two thirds of all Americans are overweight and one third are obese. With the new, highly effective antiretroviral medications, Americans with HIV now have the same weight problems as everybody else, he says. No matter who you are, if you eat too much and you dont exercise, youre going to be at risk for insulin resistance, cardiovascular disease, and every other problem associated with being overweight.


'/>"/>
Contact: Steve Tokar
steve.tokar@ncire.org
415-221-4810 x5202
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Foremost gene therapy for chest pain
3. Harm to the chest can be destructive
4. Indian Cherry: Richest Source of Vitiamin C
5. The Best Way To Relieve Chest Pain
6. The Options For Relieving Chest Pain In the Elderly Questioned
7. The Link Between Migraines And Chest Pain
8. Chest Pain Can Be Identified By New Tracer Chemical 30 Hours After Pain Relief
9. Arjun Singh In Hospital After Chest Pains
10. Unique Smoking Helpline Launched In Manchester
11. Unique Smoking Helpline Launched In Manchester
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: