Navigation Links
Fat in organs and blood may increase risk of osteoporosis
Date:7/15/2013

OAK BROOK, Ill. -- Excess fat around the belly has recently been identified as a risk factor for bone loss. Now, a new study has determined that excess liver and muscle fat also may be detrimental to bone.

The study, published online in the journal Radiology, found that obese people with higher levels of fat in their liver, muscle tissue and blood also have higher amounts of fat in their bone marrow, putting them at risk for osteoporosis.

"Obesity was once thought to be protective against bone loss," said study lead author Miriam A. Bredella, M.D., a radiologist at Massachusetts General Hospital and associate professor of radiology at Harvard Medical School in Boston. "We have found that this is not true."

While other studies have examined the relationship between visceral fat and bone mineral density, this study looked at fat inside bone marrow, the spongy tissue inside the bones of the body that produces stem cells.

"In our study, we focused on bone marrow fat because that is where our stem cells can develop into osteoblaststhe cells responsible for bone formationor fat cells," Dr. Bredella said. "We also wanted to look at the relationship between bone marrow fat and other fat components, such as those in the liver and muscle."

Dr. Bredella and colleagues used proton magnetic resonance spectroscopy (MRS), a technique that allows for precise measurement of fat, to examine 106 men and women, ages 19 to 45 years, who were obese based on body mass index measurements, but otherwise healthy.

"MRS has no radiation, is quick to perform and can quantify the amount of fat within bone marrow, muscle and liver," Dr. Bredella said.

The MRS results showed that people with more liver and muscle fat had higher levels of fat in their bone marrow, independent of body mass index, age and exercise status. HDL cholesterol, the "good" type of cholesterol that is associated with a lower risk of heart disease, was inversely associated with bone marrow fat content.

Higher levels of bone marrow fat put people at increased risk of fracture, according to Dr. Bredella.

"Bone marrow fat makes bones weak," she said. "If you have a spine that's filled with fat, it's not going to be as strong."

Triglycerides, the type of fat found in the blood, also had a positive correlation with bone marrow fat, possibly because they stimulate osteoclasts, a type of cell that breaks up bone tissue.

More research is needed to further illuminate the mechanism behind this differentiation of stem cells. Dr. Bredella noted that cell-signaling molecules called cytokines are known to promote the conversion of stem cells into fat.

"Obesity can shift stem cell lineage, resulting in more bone marrow fat," she said.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
2. More Kids Getting Donor Organs, But Gaps Persist, Study Finds
3. Researchers Turn from Drugs to Mini Organs for Diabetes Cure, According to Yasmin Malhotra
4. Artificial Organs (Medical Bionic Implants) Market is expected to grow at a CAGR of 7.1% & to reach $17.82 billion by 2017 - New Report by MarketsandMarkets
5. Many patients who die while awaiting liver transplant have had donor organs declined
6. 3 types of fetal cells can migrate into maternal organs during pregnancy
7. US Drug Watchdog Now Urges DePuy Pinnacle Hip Implant Recipients To Call Them About A Vital Blood Test To Determine A Premature Failure-Don't Miss Out On Compensation
8. Update on Yaz, Yasmin Lawsuits Alleging Blood-Clotting Side Effects: Resource4thePeople Reports Number of Consolidated Cases Climbs to Nearly 10,000
9. African-Americans with blood cancer do not live as long as Caucasians, despite equal care
10. African Americans with blood cancer do not live as long as caucasians, despite equal care
11. DNA particles in the blood may help speed detection of coronary artery disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of ... 84 percent of parents report speaking with their child about sex related topics, less ... diseases. , Mediaplanet is proud to announce the launch of its second edition of ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the ... its unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition ... has been available in several ShopRite and FoodTown stores in NJ and received rave ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... to needy individuals and families from eight different sites throughout Miami-Dade and Broward ... Over 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual ...
(Date:11/30/2016)... ... 30, 2016 , ... Northridge dentists, Dr. Assili ... for all patients. Understanding that budget can play a part in oral health ... perks, including discounts on many valuable dental treatments. Options for individuals, couples, and ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... have been a focus of public policymakers and system stakeholders in many states. ... released its Medical Price Index for Workers’ Compensation, Eighth Edition (MPI-WC) . ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec. 2, 2016  The Addiction Treatment Advisory ... of Managed Care Pharmacy (AMCP), has released detailed ... address the opioid addiction crisis, including through improved ... ATAG,s newly released paper, "The Role ... Naloxone," addresses many issues around gaps and barriers ...
(Date:12/2/2016)...  Maxor National Pharmacy Services, LLC ("Maxor"), today announced that ... The combination of Texas -based Maxor Specialty ... bring together both company,s clinical expertise and high-touch patient service ... specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... -- CVS Health Corporation (NYSE: CVS ) ... December 15, 2016, beginning at 8:00 a.m. (ET). Senior members ... in-depth review of the company,s strategies to drive long-term ... discuss 2017 earnings guidance during the event. ... be broadcast simultaneously on the Investor Relations portion of ...
Breaking Medicine Technology: