Navigation Links
Fat in Males, Females Differs Genetically, Mouse Study Shows
Date:5/20/2010

Finding might explain why men store fat around belly, women around the hips

THURSDAY, May 20 (HealthDay News) -- Male fat tissue and female fat tissue are genetically distinct from one another, new research on lab animals reveals.

The observation -- based on work conducted solely with mice -- might explain why men tend to store fat in their bellies, while women tend to pile it on their hips.

Researchers from UT Southwestern Medical Center explored the question by focusing on the fat distribution patterns of mice, which are similar to those of people. Genes were taken from the belly and hip fat of male mice and female mice, as well as from female mice whose ovaries had been removed to mimic human female menopause.

A genetic comparison of the removed fat cells revealed that out of approximately 40,000 mouse genes, only 138 were common to both genders.

"This was completely unexpected," Dr. Deborah Clegg, UTSMC senior author and assistant professor of internal medicine, said in a news release. "We expected the exact opposite -- that 138 would be different and the rest would be the same between the sexes."

Clegg and her colleagues note that men tend to carry excess weight around their gut area, while pre-menopausal women are more likely to carry it around their butt, hips, and thighs. After menopause, stored fat in women then shifts to the waist area, following a drop in ovarian hormone levels.

Aside from genetic differences, fat tissue also seemed to differ in other basic ways, as male mice fed a high-fat diet for 12 weeks gained more weight than similarly fed female mice. Male fat tissue also seemed more prone to inflammation than female fat tissue, the authors noted.

On the other hand, female mice whose ovaries had been removed started to exhibit weight gain and inflammation patterns similar to those of the male mice.

The findings led the research team to suggest that ovarian hormones play a critical role in where fat gets deposited in women.

The finding is reported in the current issue of the International Journal of Obesity.

More information

For more on body fat, visit the American Heart Association.



-- Alan Mozes



International Journal of Obesity, May 14, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. College Age Females Can Kiss Chlamydia Goodbye for Valentines Day
2. Beating Heart Differs by Gender, Age: Study
3. New UCSF Studies Reveal that Age-Related Nerve Decline is Associated with Inflammation and Differs by Gender
4. Association of fiber and colorectal cancer risk differs depending on dietary assessment method
5. Substance Abuse in Mexican Americans Differs by Gender
6. Scientists Turn Mouse Skin Cells Into Nerve Cells
7. ALPCO Announces the Launch of Rat and Mouse Proinsulin ELISA Kits
8. Mouse Study May Advance Multiple Sclerosis Research
9. Schizophrenia mouse model should improve understanding and treatment of the disorder
10. Rapamycin rescues learning, memory in Alzheimers mouse model
11. NIA researchers find gene to explain mouse embryonic stem cell immortality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: