Navigation Links
Fat cells play key role in development of type 2 diabetes
Date:7/6/2010

CINCINNATICellular changes in fat tissuenot the immune systemlead to the "hyperinflammation" characteristic of obesity-related glucose intolerance and type 2 diabetes, according to new research from the University of Cincinnati (UC).

Cancer and cell biology experts say this new discovery about the cellular mechanisms behind glucose intolerance may provide a different target for drugs to treat type 2 diabetes as well as insights into how aggressive cancers form.

The study, led by Jorge Moscat, PhD, is reported in the July 7, 2010, issue of the scientific journal Cell Metabolism.

For this study, Moscat and his UC collaborator Maria Diaz-Meco, PhD, looked at the role of a specific gene known as protein kinase C (PKC)-zeta, which has been implicated as a key cellular contributor to malignant tumor growth. Using a preclinical animal model, they found that PKC-zeta had a dual role in the molecular signaling that leads to inflammation, switching from acting as a regulator of inflammation to a proinflammation agent in different circumstances.

"This finding is quite novel because current drug development efforts target immune cells (macrophages, T-cells) to eliminate this hyperinflammation. Our research suggests obesity-related glucose intolerance has nothing to do with the immune system. It may be more effective to target adipocytes (fat cells)," explains Moscat, principal investigator of the study and chair of UC's cancer and cell biology department.

In normal cells, explains Moscat, PKC-zeta regulates the balance between cellular inflammatory responses to maintain glucose control. During obesity-induced inflammation, however, the function of PKC-zeta changes and the molecule begins to promote inflammation by causing adipocytes to secrete a substance (IL-6) that travels in large quantities to the liver to cause insulin resistance.

"We believe a similar mechanism of action is at play in malignant tumor development. Now we are trying to understand how PKC-zeta regulates IL6 to better determine how we can manipulate the protein to help prevent diabetes and cancer," he adds.

Moscat and his team are working with investigators at UC's Drug Discovery Center to screen compounds that will inhibit PKC-zeta to be used in further research.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Loss of gene function makes prostate cancer cells more aggressive
3. Mechanism discovered by which bodys cells encourage tuberculosis infection
4. Scientists discover enzyme that cleans cancer cells
5. Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says
6. Stem cell breakthrough: Bone marrow cells are the answer
7. Researchers find leukemia cells metabolize fat to avoid cell death
8. Aging of Blood Stem Cells May Be Reversible
9. Scientists Turn Mouse Skin Cells Into Nerve Cells
10. Fat tissue may be a source of valuable blood stem cells, study says
11. Scientists discover cells critical to childhood leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... , ... Delta Dental of California and its affiliated companies announced today that ... who recently retired as president and CEO of Delta Dental of California and its ... Year , helped lead the effort to raise funds for studies to strengthen pancreatic ...
(Date:2/8/2016)... ... February 08, 2016 , ... Discover the Rocky Mountain ... 1,400 booths and 700 companies. Attendees also get to see the most incredible ... Garden & Home Show , at the Colorado Convention Center - 700 14th St. ...
(Date:2/8/2016)... ... ... Guruji Mahendra Kumar Trivedi is offering 3 days of accelerated personal growth ... on February 10th. During this time, people can achieve better health, greater wealth, ... from over 40 different countries as an “ordinary man with an extraordinary gift.” ...
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart ... employers and organizations with the tools and information to lower the costs, and ... cut the cost of providing employee healthcare benefits by as much as 22%:, ...
(Date:2/6/2016)... , ... February 06, 2016 , ... Shark Finds ... announce the launch of a new DRTV campaign with Belly Bands. , Having a ... everything from sprays to puppy pads and find nothing works, get Belly Bands, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... -- ivWatch, a medical devices company, is one of five recipients ... Terry McAuliffe,s office. ivWatch will be receiving the ... event to be held at the Science Museum of ... business that have made significant contributions to science. ... ...
(Date:2/5/2016)... -- Aralez Pharmaceuticals Inc. ("Aralez") today announced the completion of ... Canada Inc. ("Tribute") following approval of the transaction by ... company will operate under Aralez Pharmaceuticals Inc. ("Aralez"), a ... Canada , Ireland and ... terms of the Agreement and Plan of Merger and ...
(Date:2/5/2016)... Feb. 5, 2016  Venice,s newest laser clinic, ... first of its kind in the area and ... advanced laser treatment. The physician-owned and operated laser ... Suncoast by storm with its revitalizing skin care ... multi-wavelength Astanza Trinity technology. http://photos.prnewswire.com/prnh/20160204/329957 ...
Breaking Medicine Technology: