Navigation Links
Fat around heart may be early indicator of coronary disease
Date:8/15/2011

OAK BROOK, Ill. Researchers have found more evidence supporting the role of fat around the heart in promoting atherosclerosis, according to a study published online in the journal Radiology.

New results from the Multi-Ethnic Study of Atherosclerosis (MESA) show that pericardial fat is more strongly related to coronary artery plaque than either body mass index (BMI) or waist circumference.

When plaque forms in the arteries, it deposits in an irregular manner, causing thickening of the artery wall on one side, but not the other. The ratio of the thick side to the thin side is referred to as plaque eccentricity and is a strong indicator of heart disease.

According to the American Heart Association, heart disease is the leading cause of death in the U.S. In 2010, an estimated 785,000 Americans had a new heart attack, and about 470,000 had a recurrent attack. Every 60 seconds, one person in the U.S. dies from a heart attack.

While previous studies have looked at the relationship of pericardial fat to atherosclerosis in patients with severe coronary disease, this is the first study to determine the association of pericardial fat on coronary artery plaque burden in asymptomatic individuals.

"The individuals in this study had no symptoms and were otherwise healthy," said senior author David A. Bluemke, M.D., Ph.D., director of Radiology and Imaging Sciences at the National Institutes of Health (NIH) Clinical Care. "They did not have significant coronary artery narrowing. Yet, despite this, they had coronary plaque that could be detected by MRI."

For the study, 183 individuals without clinical cardiovascular disease were recruited from the Baltimore and Chicago field centers of MESA, a study funded by the NIH. Participants included 89 women and 94 men with a mean age of 61 years.

"The individuals were fairly representative of the U.S. population, although the majority were overweight," Dr. Bluemke said.

The researchers used magnetic resonance imaging (MRI) to measure coronary artery eccentricity (ratio of maximal to minimal artery wall thickness) as a measure of early-stage atherosclerosis and computed tomography (CT) to determine pericardial fat volume.

"Pericardial fat is located behind the sternum, around the heart, and we cannot see it except with CT or MRI," Dr. Bluemke said. "In some people, extra fat forms preferentially in this area. We do not know why. However, extra fat around the heart is generally associated with being overweight or obese."

The results showed that pericardial fat volume correlated significantly with the degree of plaque eccentricity in both men and women. After adjustment for BMI, waist circumference, traditional risk factors, C-reactive protein level and coronary calcium content, the relationship between pericardial fat and plaque eccentricity remained significant in men, but not in women.

"The findings indicate yet another reason that obesity is bad for us," Dr. Bluemke said. "It is particularly bad when the fat forms around the heart, since the heart fat appears to further promote coronary artery plaque."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Prostate cancer gets around hormone therapy by activating a survival cell signaling pathway
2. Paper and computer workarounds challenge but may improve health IT
3. Changing trends in hip fracture incidence around the world
4. Around 25 percent of health messages in Spanish text books are not based on scientific evidence
5. Germs Thrive on Horns Passed Around in School Bands: Study
6. Removing 2mm around breast cancer tumors prevents residual disease in 98 percent of patients
7. Difficult Dialogues Initiative promotes diversity at MU, around country
8. Pay-for-performance programs improve radiology report turnaround times, study suggests
9. LapBandDoctors.com Announces Open Membership To Lap Band Surgery Professionals Around The Country.
10. Reading Comes Easier for Kids When Rovers Around
11. Shining a light around corners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: