Navigation Links
Fat-Sensing Hormones Might Fight Obesity
Date:11/26/2008

Study with rodents shows the molecules help regulate appetite

WEDNESDAY, Nov. 26 (HealthDay News) -- As you push your chair back from the Thanksgiving table this year, a molecule produced in the small intestine will be swarming through your bloodstream, ready to register on your brain the impact of the fat you've just consumed.

For now, the signal might keep you feeling full for a while. But, researchers are hoping that one day variations of this family of hormones -- known as N-acylphosphatidylethanolamines, or NAPEs -- can be used to control appetite and therefore obesity.

"We're excited but we have to be cautious," said Dr. Gerald Shulman, senior author of a study in rats that's published in the Nov. 26 issue of the journal Cell. "We would love to be able to take this to man tomorrow because we need effective ways to treat obesity and, right now, we have very few agents that work effectively. But we have much work to do."

Shulman is an investigator at the Howard Hughes Medical Institute and a professor of internal medicine and of cellular and molecular physiology at Yale University School of Medicine.

Shulman's research team had been looking for a new, fat-derived signal that might regulate food intake. A sensitive blood-screening test -- called LC tandem mass spectrometry -- turned up the NAPE group of molecules.

Levels of NAPEs increased consistently in rats and mice that had just eaten a fatty meal. And when synthesized and re-injected into the lab rodents, NAPEs shut down the rodent's food intake, with one dose lasting 12 hours or longer. NAPEs also entered the brain, appearing to concentrate in the hypothalamus, an area with a high concentration of neurons involved in the regulation of food intake, the researchers said.

Rats receiving NAPEs chronically (through a catheter in the jugular) ate less and lost weight.

"That's what we have, a gut-derived fat that works centrally to inhibit food intake," Shulman said.

Shulman and his colleagues believe that aberrations in how NAPEs are secreted in people who eat lots of high-fat foods may contribute to obesity. "Some of our animal data suggests that NAPE secretion is dysregulated in our animal models of diet-induced obesity," Shulman said.

"We're moving up the species ladder to see if chronic NAPEs reduces food intake and is well-tolerated in non-human primates," Shulman said. "If everything there looks good, that would give us a lot of motivation to actually do trials in humans."

David Earnest, professor of neuroscience and experimental therapeutics at Texas A&M Health Science Center College of Medicine, said, "The NAPEs work to suppress appetite or decrease food intake, [but] feeding is a complex behavior. There are a lot of factors that figure into eating disorders. The findings are very interesting and exciting, basically because we have identified these NAPEs which are synthesized by the gut and presumably can be used in supplementary fashion to treat obesity in humans."

"Unfortunately, things don't always work out according to plan," he added. "Not to say that NAPEs don't offer hope. These are some encouraging observations."

More information

The U.S. Centers for Disease Control and Prevention has more on obesity and overweight.



SOURCES: Gerald Shulman, M.D., Ph.D. investigator, Howard Hughes Medical Institute, and professor of internal medicine and of cellular and molecular physiology, Yale University School of Medicine, New Haven, Conn.; David Earnest, Ph.D., professor of neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine; Nov. 26, 2008, Cell


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Reduce Stress Hormones to Beat Sleep Problems
2. Experts call for better research into link between womens hormones and mood disorders
3. FDA Asserts New Policy to Restrict Womens Access to Bioidentical Hormones
4. Sex Hormones Dont Seem to Affect Prostate Cancer Risk
5. Heart Hormones Beat Back Cancers in Mice
6. ENDO 08: Latest news on hormones, steroids, obesity, diabetes and more
7. Patients, Doctors, Pharmacists Praise Bipartisan House Resolution on Compounded Hormones Containing Estriol
8. Menopause: Hot Flashes Can Be Reduced 90% without Hormones
9. Age alone should not be used to determine whether to treat prostate cancer with hormones
10. Breast Cancer Action Targets Yoplait in Think Before You Pink Campaign; Calls for Yogurt Without Artificial Hormones
11. Hormones May Be to Blame for Womens Cavity Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... ... The Smart Machine Age is here, and it’s disrupting everything. Not only could ... in the United States may be taken over by technology in the next five ... steamrolls over colleagues is drawing to a close. Success will belong to those who ...
(Date:2/24/2017)... ... ... With millions of Americans and people worldwide struggling with ... aware of our options and are empowered with strength and information throughout the ... newest edition of "Vision and Hearing" in USA Today, that will educate readers ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... 2017 , ... The California State University Institute for Palliative Care ... interested in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: Advancing ... Diego on Sept. 28 and 29, 2017, on the campus of California State University ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top five ... art competition. Selected from 15 submissions from around the nation, the top five finalists ... iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the competition ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Ind. , Feb. 24, 2017 Zimmer ... leader in musculoskeletal healthcare, will present at the Cowen ... at the Boston Marriott Copley Place on Tuesday, March ... A live webcast of the presentation can be ... archived for replay following the conference via Zimmer Biomet,s ...
(Date:2/24/2017)... Feb. 24, 2017 Physician General Dr. ... Alcohol Programs Jennifer Smith commended South Central ... for and using naloxone, a life-saving overdose reversal drug. ... a recovery specialist and overdose survivor who was saved ... "A significant part of fighting the opioid ...
(Date:2/24/2017)... 2017 The U.S. Food and Drug ... Kit, performed on the Pheno System. This is ... bloodstream infections and provide information about which antibiotics ... sensitivity). The test also reduces the amount of ... which can guide antibiotic treatment recommendations more quickly. ...
Breaking Medicine Technology: