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Fat-Fighting Chemical Holds Promise
Date:8/27/2009

potential side effects, particularly if the chemical is ingested over many years," noted Dr. Nicholas H.E. Mezitis, assistant professor of clinical medicine at Columbia University College of Physicians and Surgeons, who is familiar with the study findings.

For the moment, it is "still challenging" to develop drugs that safely treat obesity, said metabolism researcher Dr. Tae-Hwa Chun, who also is familiar with the report.

A positive finding "in cells and rodents does not always lead to the development of safe and effective drugs for patients," added Chun, an assistant professor at the University of Michigan who specializes in metabolic syndrome.

Still, Chun said, there's promise in the idea of targeting genetic switches that turn on fat production, as fatostatin appears to do.

More information

Learn more about obesity from the National Institutes of Health.



SOURCES: Motonari Uesugi, Ph.D., researcher, Kyoto University, Japan; Tae-Hwa Chun, M.D., Ph.D., assistant professor, University of Michigan, Ann Arbor; Nicholas H.E. Mezitis, M.D., assistant professor of clinical medicine, Columbia University College of Physicians and Surgeons, New York City; Aug. 28, 2009, Chemistry and Biology


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