Navigation Links
Fat Cell Protein Boosts Heart Attack Risk in Elderly

Higher adiponectin levels may indicate underlying disease, study finds

FRIDAY, Aug. 8 (HealthDay News) -- A protein produced by fat cells may play a pivotal role in increasing an older American's risk for a heart attack even if they are losing weight, a new report says.

Levels of adiponectin increase in the bloodstream when people lose weight and appear to endanger the cardiovascular health of older people, according to the new study to be published in The Journal of Clinical Endocrinology & Metabolism.

This finding, though, appears odd, because past studies have shown high adiponectin concentration is associated with lower risks of diabetes and cholesterol abnormalities.

"This study is significant because previous findings have been contradictory, and the present investigation includes the largest number of heart attacks in an elderly group to date," Dr. Jorge Kizer, an associate professor of medicine and public health at Weill Cornell Medical College in New York City, said in a news release issued by the journal's publisher. "Our findings make a persuasive case that adiponectin is in fact associated with an increase in heart disease risk in older persons."

The new study looked at a sample of 1,386 adults, aged 65 to 100, from around the country. Of these, 604 had heart disease, with those with the highest adiponectin levels being most likely to suffer a heart attack.

The researchers theorized that higher adiponectin levels may indicate underlying disease, or even have direct harmful effects especially in the elderly. Previous studies show adiponectin increases energy expenditure in the central nervous system of mice -- something that could be significantly harmful if also occurring in older adults by accelerating the loss of skeletal muscle.

The findings are consistent, though, with other recent studies tying high adiponectin to mortality in the elderly.

"This study shows that this abundant product of fat cells is a marker and perhaps even a mediator of worsened outcomes in persons aged 65 years and older," Kizer said.

More information

The National Institute of Health has more about healthy aging.

-- Kevin McKeever

SOURCE: The Endocrine Society, news release, July 30, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Protein Key to Brain Rewiring
2. Recipe for cell reprogramming adds protein
3. Key to virulence protein entry into host cells discovered
4. DIA/AAPS Co-Sponsored Conference to Examine the Immunogenicity of Therapeutic Proteins
5. Protein made by fat cells may increase risk of heart attack in older adults
6. Scientists ID Jekyll-Hyde Protein in Lou Gehrigs Disease
7. A High-Density Lipoprotein Raising Drug That Has a Lower Discontinuation Rate Than That of Extended Release Niaspan Would Earn a 20 Percent Patient Share in the Dyslipidemia Drug Market
8. Protein Gives Doctors New Tool to Detect Melanoma
9. Protein Thought to Promote Cancer Does Opposite
10. Pressured proteins: A little pressure in proteomics squeezes 4-hour step into a minute
11. Discovery of key malaria proteins could mean sticky end for parasite
Post Your Comments:
(Date:11/25/2015)... ... 25, 2015 , ... In an ongoing Clinical Study conducted by an independent ... UV Angel is evaluating the efficacy of its product and its disinfection protocol. This ... beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical center ...
(Date:11/25/2015)... ... November 25, 2015 , ... In honor of Pulmonary ... individuals and groups responsible for advancing care for pulmonary hypertension (PH) patients and ... the public, will receive special recognition throughout 2016 as part of PHA’s 25th ...
(Date:11/25/2015)... ... ... Many people know of the common symptoms of low thyroid hormone (also known ... people who find their cholesterol levels and weight are creeping up are more likely ... don’t have any of the other symptoms. , Thyroid hormone plays a major role ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bunion ... in an early celebration of the early holiday shopping season. Starting Wednesday November ... (normally $33.95 ea). Black Friday promotional pricing is in addition to any automatic ...
(Date:11/24/2015)... ... November 24, 2015 , ... New patients who wish to seek ... dental implants at her Mississauga, ON practice. Dr. Williams has been providing ... of dental implants. , Missing teeth can lead to a variety of complications ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... -- The hope of bearing a child ... cycles. After failure of over 15 IVF cycles, Mrs. ... hopes that she would be able to conceive ever. But finally optimism prevailed as she ... of over 15 IVF cycles. India ... one last attempt with Gaudium IVF Center in New ...
(Date:11/24/2015)...  Thanks to a donor with a personal connection ... Sister Diane Grassilli Center for Women,s Health now offers ... San Francisco . Fred Ruhland ... a gift of $617,320 that allowed the Center to ... and Whole Breast Ultrasound. Tomosynthesis, three-dimensional (3-D) mammography for ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
Breaking Medicine Technology: