Navigation Links
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
Date:3/3/2009

Drugs blocking this communication may offer therapeutic benefits, mouse study finds

TUESDAY, March 3 (HealthDay News) -- A signal known to play a role during fasting also becomes active in the fat tissue of obese mice in the early stages of progression toward type 2 diabetes, say researchers. They also found that blocking this signal in fat tissue prevents insulin resistance in obese mice.

Previous research found that the CREB pathway keeps blood sugar in balance during fasting by triggering glucose production in the liver. It's also been found that excessive CREB activity in diabetes contributes to high blood sugar and insulin resistance.

In this new study, researchers at the Salk Institute for Biological Studies investigated whether CREB was important in mature fat tissues as well. They found that CREB activity in fat cells in obese mice encourages insulin resistance by lowering the production of a hormone called adiponectin and the insulin-sensitive glucose transporter 4 (GLUT4).

Obese mice genetically altered to lack CREB in fat cells became more sensitive to insulin and were also protected from the development of fatty liver and inflammation in fat tissue. CREB seemed relatively unimportant in healthy mice, but in obese mice, the signal appears to be "doing something more pathological."

The findings suggest the "stress of obesity activates CREB genes and contributes to insulin resistance," noted Marc Montminy and colleagues.

"Taken together, these results show that targeting therapies to adipose tissue and, in particular, to the CREB signaling system could have important therapeutic benefits in a variety of insulin-resistant states," the researchers concluded.

The study was published in the March issue of Cell Metabolism.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance and pre-diabetes.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding
2. Prolonged Fasting Boosts Risk of Rare Stroke
3. Fasting Before Chemo Protects Healthy Cells
4. Schizophrenia linked to signaling problems in new brain study
5. Vitamin A signals offer clues to treating autoimmunity
6. Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead
7. Redpine Signals Launches SenSiFi(TM), An Ultra Low-Power 802.11n (Wi-Fi(R)) Wireless Sensor Module
8. Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results
9. Spinal fluid proteins signal Lou Gehrigs disease
10. Sleep Disorder Could Signal Neurological Disease
11. Signaling between protein, growth factor is critical for coordinated cell migration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
(Date:6/23/2017)... ... 23, 2017 , ... Military Connection friend and veteran advocate Micaela ... Virgin Atlantic lounge. , Bensko is no stranger to the plight of the ... her life to supporting our wounded veterans. A world-class photographer, her riveting photos “The ...
(Date:6/23/2017)... ... ... The Aesthetic Channel has recently highlighted Dr. Ben Talei’s unique approach to ... technique that he calls the AuraLyft Facelift. The AuraLyft does more than ... expect to look refreshed, rejuvenated, and revitalized. , Dr. Talei’s unique approach stems ...
(Date:6/23/2017)... , ... June 23, 2017 , ... 21 Middle East ... (EF) has selected 21 leaders from government, business and civil society in 11 countries ... the U.S. this fall, engaging in a transformative exchange of knowledge and ideas with ...
(Date:6/23/2017)... ... 2017 , ... Ross Insurance Agency ( http://www.rossinsuranceagency.com ) saves ... Agency’s (FEMA) recent update of flood zones, more people than ever are in ... enacted to reflect the actual risk in flood zone areas during a time ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl ... services to families and business owners in and around Lackawanna County, is joining ... citizens in the area. , Meals on Wheels of NEPA provides hand-delivered and ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... , June 16, 2017 Datascope Corp. is voluntarily ... Datascope Corp. for a potential electrical test failure code.     ... PART NUMBER ... IABP CS300 IABP ... ...
(Date:6/14/2017)... June 14, 2017  ivWatch LLC, a medical device ... intravenous (IV) therapy, is pleased to announce it was ... Nonsurgical Hospital Supplies and Equipment at the 2017 Medical ... the medtech industry. The award was presented by Medical ... Javits Center in New York ...
(Date:6/14/2017)... , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away with ... platform is described by Forbes as "entering the life ... Medical Association as teaching "empathy to medical professionals in ... startup was recently named a finalist for the Department ...
Breaking Medicine Technology: