Navigation Links
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
Date:3/3/2009

Drugs blocking this communication may offer therapeutic benefits, mouse study finds

TUESDAY, March 3 (HealthDay News) -- A signal known to play a role during fasting also becomes active in the fat tissue of obese mice in the early stages of progression toward type 2 diabetes, say researchers. They also found that blocking this signal in fat tissue prevents insulin resistance in obese mice.

Previous research found that the CREB pathway keeps blood sugar in balance during fasting by triggering glucose production in the liver. It's also been found that excessive CREB activity in diabetes contributes to high blood sugar and insulin resistance.

In this new study, researchers at the Salk Institute for Biological Studies investigated whether CREB was important in mature fat tissues as well. They found that CREB activity in fat cells in obese mice encourages insulin resistance by lowering the production of a hormone called adiponectin and the insulin-sensitive glucose transporter 4 (GLUT4).

Obese mice genetically altered to lack CREB in fat cells became more sensitive to insulin and were also protected from the development of fatty liver and inflammation in fat tissue. CREB seemed relatively unimportant in healthy mice, but in obese mice, the signal appears to be "doing something more pathological."

The findings suggest the "stress of obesity activates CREB genes and contributes to insulin resistance," noted Marc Montminy and colleagues.

"Taken together, these results show that targeting therapies to adipose tissue and, in particular, to the CREB signaling system could have important therapeutic benefits in a variety of insulin-resistant states," the researchers concluded.

The study was published in the March issue of Cell Metabolism.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding
2. Prolonged Fasting Boosts Risk of Rare Stroke
3. Fasting Before Chemo Protects Healthy Cells
4. Schizophrenia linked to signaling problems in new brain study
5. Vitamin A signals offer clues to treating autoimmunity
6. Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead
7. Redpine Signals Launches SenSiFi(TM), An Ultra Low-Power 802.11n (Wi-Fi(R)) Wireless Sensor Module
8. Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results
9. Spinal fluid proteins signal Lou Gehrigs disease
10. Sleep Disorder Could Signal Neurological Disease
11. Signaling between protein, growth factor is critical for coordinated cell migration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
(Date:8/29/2014)... NC (PRWEB) August 29, 2014 Tim ... in the North Carolina General Assembly, spent the morning ... Healthcare and touring our facilities. , Representative Moffitt’s visit ... based durable medical equipment (DME) company and to discuss ... impact DME providers such as Aeroflow. , Josh ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 http://www.fdanews.com/CTMPR ... of Clinical Trials Magnifier Weekly. , Clinical Trial Magnifier ... world every week and reports all the fresh changes. ... is able to extract just the information readers need. ... drill down using links in the newsletter to focus ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 And the results ... the Turks & Caicos Islands, is voted a favorite with ... Best Island in the World in the Travelers' Choice Awards ... year, travelers from all across the globe pick their favorites, ... a winner in multiple categories. , The Venetian ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Recent reports, ... suggested that Americans today are working longer hours and ... and overstressed. APEC Water believes that drinking lots of ... Labor Day Sale on their most popular and effective ... healthy. From now until 9/2/2014, customers can save up ...
(Date:8/29/2014)... August 29, 2014 Until now, databases ... tables) or unstructured data (document stores). SQL products have ... have basically managed the wide assortment of unstructured data. ... work with Big Data is with a NoSQL Database. ... various aspects of all Big Data issues. Scientel ...
Breaking Medicine News(10 mins):Health News:North Carolina Representative Tim Moffitt Visits Aeroflow Healthcare 2Health News:FDAnews Accounces New Newsletter: Clinical Trial Magnifier Weekly Provides the Most Up-to-Date Clinical Trial Data 2Health News:FDAnews Accounces New Newsletter: Clinical Trial Magnifier Weekly Provides the Most Up-to-Date Clinical Trial Data 3Health News:FDAnews Accounces New Newsletter: Clinical Trial Magnifier Weekly Provides the Most Up-to-Date Clinical Trial Data 4Health News:Relax this Labor Day Weekend with Great Savings on Easy-Install, Do-It-Yourself Drinking and Whole House Water Filters 2Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 2Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 3Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 4
... weight loss is an important predictor of poor outcome in ... on // regarding why heart failure patients lose weight or ... focused on elevated levels of angiotensin II, a substance in ... to rise . A study conducted in mice that showed ...
... weight loss may be an early sign of dementia ... the onset of // definite dementia symptoms and accelerates ... the elderly is common and may be associated with ... people who already have dementia. For the study researchers ...
... recent study researchers have linked breathing cancer-causing compounds during ... among offspring. They also believe that nearly all childhood ... inhalation of noxious substances. ,The study compared a ... younger who died from leukemia and other cancers between ...
... brought with it a new lease of life for Organ ... uphill struggle doesn’t stop with finding a matching donor. In ... shown that despite all high tech matching done for liver ... surgeon Ignazio Marino, M.D., of Thomas Jefferson University Hospital in ...
... hormones could be responsible for some of the problems ... measuring levels of five different sex hormones in men ... those found in healthy people. All the MS patients ... brain damage characteristic of the disease. ,Results showed ...
... linked the use of estrogen replacement therapy with a lower ... ) is known as a good indicator of exposure to ... how BMD related to the risk of cognitive problems. All ... beginning of the study. Researchers then measured their BMD at ...
Cached Medicine News:
(Date:8/28/2014)... , Aug. 28, 2014  In recognition of ... health complications from the flu, pneumonia, shingles and ... have declared September to be Senior Vaccination ... age, it is important that adults ages 65 ... their vaccinations. CVS pharmacists and MinuteClinic nurse practitioners ...
(Date:8/28/2014)... , Aug. 28, 2014  Robotic surgery is ... media, both for the promise of improved outcomes ... quick deployment of surgical robots and market pressures ... facilities to evaluate their robotic surgery training programs ... team.    ECRI Institute ( www.ecri.org ...
(Date:8/28/2014)... Ohio , Aug. 28, 2014  A ... competition in generics are adding pressure to pharmaceutical, ... resources. Company resources continue to shrink and approval ... This has led companies to look for additional ... commercialization and for keeping approved products on the ...
Breaking Medicine Technology:September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 2Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 54 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 24 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 34 Key Factors to Consider When Choosing an Effective Regulatory Outsourcing Partner 4
... Nov. 3, 2010 Par Pharmaceutical Companies, Inc. (NYSE: ... ended September 30, 2010. For the third quarter ... $234.4 million and income from continuing operations of $30.7 million, ... milestone payment to Tris Pharma, Inc., a $2.3 million payment ...
... OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics ... it has been awarded $1.2 million to support ... Qualifying Therapeutic Discovery Project ("QTDP") program.  All of ... an award.  The funds will be used to ...
Cached Medicine Technology:Par Pharmaceutical Companies Reports Third Quarter 2010 Results 2Par Pharmaceutical Companies Reports Third Quarter 2010 Results 3Par Pharmaceutical Companies Reports Third Quarter 2010 Results 4Par Pharmaceutical Companies Reports Third Quarter 2010 Results 5Par Pharmaceutical Companies Reports Third Quarter 2010 Results 6Par Pharmaceutical Companies Reports Third Quarter 2010 Results 7Par Pharmaceutical Companies Reports Third Quarter 2010 Results 8Par Pharmaceutical Companies Reports Third Quarter 2010 Results 9Par Pharmaceutical Companies Reports Third Quarter 2010 Results 10Par Pharmaceutical Companies Reports Third Quarter 2010 Results 11OncoMed Pharmaceuticals Awarded Five Therapeutic Discovery Project Grants Totaling $1.2 Million 2OncoMed Pharmaceuticals Awarded Five Therapeutic Discovery Project Grants Totaling $1.2 Million 3
Unique criss-cross strapping distributes weight evenly over the torso for ultimate comfort and flexibility. Fully adjustable 2 inch belt and buckle for easy front closure....
Six inch wide elastic belt transfers the apron weight off the shoulders. 0.5mm front and 0.25mm back with a generous overlap for double protection. Shoulder pads included. Also available without wide...
Our 'flex' removes the apron weight from the shoulders while providing back support. Unlike other elastic backs, ours does not wrinkle up, making cleaning easier....
Economically priced - same high quality as our Standard, with 1" ties. Adjustable back ties keep apron snug....
Medicine Products: