Navigation Links
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
Date:3/3/2009

Drugs blocking this communication may offer therapeutic benefits, mouse study finds

TUESDAY, March 3 (HealthDay News) -- A signal known to play a role during fasting also becomes active in the fat tissue of obese mice in the early stages of progression toward type 2 diabetes, say researchers. They also found that blocking this signal in fat tissue prevents insulin resistance in obese mice.

Previous research found that the CREB pathway keeps blood sugar in balance during fasting by triggering glucose production in the liver. It's also been found that excessive CREB activity in diabetes contributes to high blood sugar and insulin resistance.

In this new study, researchers at the Salk Institute for Biological Studies investigated whether CREB was important in mature fat tissues as well. They found that CREB activity in fat cells in obese mice encourages insulin resistance by lowering the production of a hormone called adiponectin and the insulin-sensitive glucose transporter 4 (GLUT4).

Obese mice genetically altered to lack CREB in fat cells became more sensitive to insulin and were also protected from the development of fatty liver and inflammation in fat tissue. CREB seemed relatively unimportant in healthy mice, but in obese mice, the signal appears to be "doing something more pathological."

The findings suggest the "stress of obesity activates CREB genes and contributes to insulin resistance," noted Marc Montminy and colleagues.

"Taken together, these results show that targeting therapies to adipose tissue and, in particular, to the CREB signaling system could have important therapeutic benefits in a variety of insulin-resistant states," the researchers concluded.

The study was published in the March issue of Cell Metabolism.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance and pre-diabetes.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding
2. Prolonged Fasting Boosts Risk of Rare Stroke
3. Fasting Before Chemo Protects Healthy Cells
4. Schizophrenia linked to signaling problems in new brain study
5. Vitamin A signals offer clues to treating autoimmunity
6. Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead
7. Redpine Signals Launches SenSiFi(TM), An Ultra Low-Power 802.11n (Wi-Fi(R)) Wireless Sensor Module
8. Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results
9. Spinal fluid proteins signal Lou Gehrigs disease
10. Sleep Disorder Could Signal Neurological Disease
11. Signaling between protein, growth factor is critical for coordinated cell migration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... ... 2017 , ... HMP , a leader in healthcare events and education, today ... Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & ... award competition recognizes editorial and design excellence across a range of sectors. This year’s ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/19/2017)... --  ZirMed Inc ., a recognized leader in cloud-based revenue ... been ranked #1 by its users for the seventh consecutive ... Survey. ZirMed was recognized as the top-ranked end-to-end revenue cycle ... over 200 beds and holds one of the longest #1 ... ...
(Date:9/18/2017)... Sept. 18, 2017 EpiVax, Inc. ... bioinformatics and immune engineering, today announced a ... A (H7N9) vaccine. ... seasonal influenza and presents a challenge for ... exposure to be effective. Using state-of-the-art bioinformatics and ...
Breaking Medicine Technology: