Navigation Links
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
Date:3/3/2009

Drugs blocking this communication may offer therapeutic benefits, mouse study finds

TUESDAY, March 3 (HealthDay News) -- A signal known to play a role during fasting also becomes active in the fat tissue of obese mice in the early stages of progression toward type 2 diabetes, say researchers. They also found that blocking this signal in fat tissue prevents insulin resistance in obese mice.

Previous research found that the CREB pathway keeps blood sugar in balance during fasting by triggering glucose production in the liver. It's also been found that excessive CREB activity in diabetes contributes to high blood sugar and insulin resistance.

In this new study, researchers at the Salk Institute for Biological Studies investigated whether CREB was important in mature fat tissues as well. They found that CREB activity in fat cells in obese mice encourages insulin resistance by lowering the production of a hormone called adiponectin and the insulin-sensitive glucose transporter 4 (GLUT4).

Obese mice genetically altered to lack CREB in fat cells became more sensitive to insulin and were also protected from the development of fatty liver and inflammation in fat tissue. CREB seemed relatively unimportant in healthy mice, but in obese mice, the signal appears to be "doing something more pathological."

The findings suggest the "stress of obesity activates CREB genes and contributes to insulin resistance," noted Marc Montminy and colleagues.

"Taken together, these results show that targeting therapies to adipose tissue and, in particular, to the CREB signaling system could have important therapeutic benefits in a variety of insulin-resistant states," the researchers concluded.

The study was published in the March issue of Cell Metabolism.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about insulin resistance and pre-diabetes.



-- Robert Preidt



SOURCE: Cell Press, news release, March 3, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bowel prep oral sodium phosphate equal to fasting before capsule endoscopy for obscure GI bleeding
2. Prolonged Fasting Boosts Risk of Rare Stroke
3. Fasting Before Chemo Protects Healthy Cells
4. Schizophrenia linked to signaling problems in new brain study
5. Vitamin A signals offer clues to treating autoimmunity
6. Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead
7. Redpine Signals Launches SenSiFi(TM), An Ultra Low-Power 802.11n (Wi-Fi(R)) Wireless Sensor Module
8. Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results
9. Spinal fluid proteins signal Lou Gehrigs disease
10. Sleep Disorder Could Signal Neurological Disease
11. Signaling between protein, growth factor is critical for coordinated cell migration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fasting Signal' Offers Clues to Insulin Resistance in the Obese
(Date:12/4/2016)... ... December 03, 2016 , ... Penrose ... in the Dallas area” Tuesday evening at the 26th Annual SMU Cox Dallas ... SMU's Cox School’s Caruth Institute for Entrepreneurship. Dallas 100™, co-founded by the Caruth ...
(Date:12/2/2016)... California (PRWEB) , ... December 02, 2016 , ... Halfway ... Dental Medicine has provided preventative dental services to more than 15,900 children 5 years ... First 5 LA pledged $38 million over a span of five years to Western ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... across the Dothan-Wiregrass Area in Alabama are expected to attend the UNCF Dothan-Wiregrass ... will help provide scholarship funds for area students and operating support to UNCF-member ...
(Date:12/2/2016)... ... , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of the ... inspired to practice medicine at an early age by his father, who was also ... and prescribing medicine,” he states. “It is about building relationships with people; relationships that ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is ... USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that ... “We are prolonging life 6 years in the last 3 decades,” says Dr. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... the largest share in the ECG Cables And ECG Leadwires ... remote monitoring ECG devices. On the other hand, the ... the highest growth rate during the forecast period. ... Company (U.S.), Medtronic plc ( Ireland ), Koninklijke ... Medical International Limited ( China ), held major ...
(Date:12/2/2016)... Research and Markets has announced the addition of the "Global ... report to their offering. ... , The global ultrasound device market ... to grow at a CAGR of 5.5% during 2016-2022. Based on portability, ... forecast period, a CAGR of 8.8% in the global market. Among the ...
(Date:12/2/2016)... , Dec. 2, 2016  PipelineRx, a leading medication ... be offering demonstrations of its SaaS-based telepharmacy platform, ... Health-System Pharmacists 2016 Midyear Clinical Meeting and Exhibition, ... . With nearly 300 hospital clients nationally, the ... technology designed to dramatically improve pharmacy operations, enhance ...
Breaking Medicine Technology: