Navigation Links
Fast track to vascular disease
Date:6/3/2011

In Western societies, atherosclerosis of the arteries is one of the leading causes of death. Chronic, localized inflammation of the blood vessel wall facilitates the growth of fibrous plaques, which leads to narrowing or occlusion of the vessel, and thereby promotes heart attacks and stroke. The persistence of the inflammatory reaction is due to a loss of control over the activity of the immune system. So-called dendritic cells are known to play a central role in the adaptive immune response, functioning as activators of other classes of immune cells. Their precise contribution to the pathogenesis of atherosclerosis has, however, been unclear. An international team of researchers led by Professor Christian Weber of Ludwig-Maximilians-Universitt (LMU) Munich and Privatdozentin Alma Zernecke of Wrzburg University has now demonstrated that dendritic cells release the chemokine CCL17 as a signal molecule, which inhibits a feedback mechanism that normally limits the activity of the immune system. This explains why the normally transient inflammatory response is not turned off and becomes chronic. The new study has also identified a potential antidote to the signal molecule. As Professor Weber reports, "We were able to prevent the progression of atherosclerosis using an antibody raised against CCL17." In other words, CCL17 offers a promising starting point for the development of new therapeutic strategies. (Journal of Clinical Investigation, 1 June 2011)

Atherosclerosis can become manifest in various ways. In particular, plaques may suddenly rupture, promoting the formation of a clot that occludes the vessel. If this afflicts the vessels of the heart or brain the result is a heart attack or a stroke. The narrowing of vessels caused by plaque growth can also lead to reduction of the blood supply to the lower limbs and to so-called vascular dementia. Atherosclerosis is initiated by lipid accumulation that occurs directly beneath the inner lining of the
'/>"/>

Contact: Dr. Christian Weber
kreislaufinstitut@med.uni-muenchen.de
49-895-160-4350
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tracking Swine Flu Virus in Pigs Reveals Mutations
2. Studies show Vectra(TM) DA can track early response to rheumatoid arthritis therapy
3. UofL nursing faculty honored for race track clinic success
4. New scientific model tracks form of ovarian cancer to origins in fallopian tube
5. New database to help track quality of medicines in global markets
6. Tracking down the origin of leukemia relapse
7. University of Cincinnati team to track tumor DNA through bloodstream
8. Tet further revealed: Studies track protein relevant to stem cells, cancer
9. IU study: Smoke-free air law had no effect on off-track betting facility business activity
10. New study to use smart phones to track air pollution exposure
11. People Appear to Use Senses to Keep Track of Time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... December 21, 2014 BambooIndustry.com is ... Recently, the business has announced its bamboo flooring ... the best material from certified suppliers, and offers ... customers worldwide. In the current promotion, all customers ... off, when they say they know BambooIndustry.com from ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... the healthcare sector have benefited the Massage Services ... the discretionary characteristics of industry products, the anticipated 1.0% ... five-year period has provided consumers with the means to ... that have received a massage in a given year ...
(Date:12/20/2014)... print component of Healthy Aging is distributed within today’s ... and an estimated readership of 420,000. The digital component ... and across a network of top news sites and ... campaign, click here . , The publication features ... The Social. Lainey Lui, Melissa Grelo, Traci Melchor, ...
(Date:12/20/2014)... The Doctor’s Office Urgent Care of Paramus, New Jersey ... decade. They’ve treated over 40,000 patients while carrying out ... alternative to the Paramus area. , For 2015, the ... staff of top-notch board certified physicians: Christine Milosis MD, Sandra ... new doctors will work tirelessly to carry out The ...
(Date:12/20/2014)... Atore, Inc, (San Francisco, CA CEO: Masashi ... focused portal on December 17th, 2014. , One ... US and Japan. , MERRY BIRTHDAY SITE : ... , MERRY BIRTHDAY MESSAGE is part of 5 future ... Features, Choose from thousands of stock photos to decorate ...
Breaking Medicine News(10 mins):Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:Atore, Inc. Releasing the First Birthday Portal 2
... , THURSDAY, Oct. 6 (HealthDay News) -- Researchers have ... cerebrospinal fluid (CSF) of patients with HIV-associated dementia. ... developing neurological difficulties increases as AIDS patients live longer, ... greatest risk for the problem, according to the U.S. ...
... 10 million people age 12 or older are estimated to ... prior year, according to a 2009 National Survey on Drug ... non-alcohol drug in drivers, its role in causing crashes has ... by drivers and risk of a car accident, researchers at ...
... (HealthDay News) -- New research suggests certain long-term psychotherapies ... preventing post-traumatic stress disorder (PTSD) following a traumatic event. ... treatment for PTSD didn,t seem to boost a person,s ... acceptable option when early clinical interventions cannot be provided," ...
... method of diagnosing sinusitis is presented in a new thesis from ... of antibiotics and the costs of the disease to society. ... an acute and a chronic form. In Europe, over nine per ... author of the thesis is Pernilla Sahlstrand Johnson, a PhD student ...
... News) -- Technology that directly oxygenates the blood reduced the ... the H1N1 flu virus, a new British study shows. ... noted that debate continues about the use of the technology, ... extracorporeal membrane oxygenation, which oxygenates the blood. It,s used to ...
... 6 (HealthDay News) -- People whose parents had a drinking ... they,re under stress, a new study says. Swedish researchers ... they had a family history of alcohol abuse. Both groups ... timed conditions in public) and then allowed to drink. ...
Cached Medicine News:Health News:Scientists Spot New Clues to HIV-Linked Dementia 2Health News:Marijuana use may double the risk of accidents for drivers 2Health News:Researchers Assess What Works Best to Prevent PTSD 2Health News:New method to diagnose sinusitis could reduce use of antibiotics 2Health News:Oxygenating Blood of Hospitalized H1N1 Flu Patients Saved Lives: Study 2
(Date:12/17/2014)... STUTTGART , Alemania, December 17, 2014 ... del año anterior, con un alto nivel de gasto ... pasado año fiscal 2013/14 (finalizado el 30 de septiembre ... por ciento a 4.287 millones de euros (año anterior: ... de la moneda desfavorables. Las ganancias (EBIT) crecieron un ...
(Date:12/17/2014)... Dec. 17, 2014 With advancements in ... MRI market is seeing new growth, according to ... scans account for the majority of market volume, ... of images, which are creating opportunities for more sophisticated ... is growing at a rate of 4%, with ...
(Date:12/17/2014)...  IGI Laboratories, Inc. (NYSE MKT: IG; "IGI" or ... of $125 million aggregate principal amount of 3.75% Convertible ... offered and sold only to qualified institutional buyers pursuant ... as amended (the "Securities Act"). The Notes ... year, payable semiannually in arrears on June 15 and ...
Breaking Medicine Technology:ZEISS confirma su posición en un entorno difícil 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... March 5, 2012  RoundTable Healthcare Partners ("RoundTable"), an ... healthcare industry, announced today that Kent J. Davies ... RoundTable III Platform Development Corporation ("RPDC"), a Fund ... focus his attention on the identification and development ...
... -- Database101.com, a leading provider of email marketing, ... businesses and salespeople, will now offer its mailing lists and ... for marketers and salespeople. "Many marketers and small ... finding new ways to market successfully" said Vin Gupta, founder ...
Cached Medicine Technology:RoundTable Healthcare Partners Names Kent J. Davies CEO of Newly Formed Platform Development Corporation 2Database101.com Offers Hot Sales Leads & Email Lists, ONLINE, with NO Minimum Order! 2
... The TL-100 uses technology that takes ... by automatically detecting and reading them. It ... recording the results, mark lenses as you ... contact lenses. Easy to use, the TL-100 ...
... The Kowa RC-XV3 camera is ... The automatic exposure system, ... sensitivity, the 2.5~300ws watt indication ... handling are the basic features ...
FF 450plus fundus camera for 35mm photography. Upgradeable basic instrument for brilliant image quality....
The new TRC-NW6 non-mydriatic retinal camera is the ideal instrument for the growing market in telemedicine and diabetic screening....
Medicine Products: