Navigation Links
Fast-acting enzymes with 2 fingers: Protein structurally and dynamically explained
Date:12/19/2012

Researchers at the RUB and from the MPI Dortmund have uncovered the mechanism that switches off the cell transport regulating proteins. They were able to resolve in detail how the central switch protein Rab is down-regulated with two "protein fingers" by its interaction partners. The structural and dynamic data is reported by the researchers led by Prof. Dr. Klaus Gerwert (Chair of Biophysics, RUB) and Prof. Dr. Roger S. Goody (Max Planck Institute for Molecular Physiology, Dortmund, Germany) in the Online Early Edition of the journal PNAS. "Unlike in the cell growth protein Ras, which is regulated with only one 'finger', we have surprisingly found a two-finger switch-off mechanism in Rab. This throws a completely new light on the functioning of certain enzymes, the small GTPases, to which Rab belongs", Klaus Gerwert explains.

Switch proteins associated with various diseases

Unlike Ras proteins that regulate cell growth, Rab GTPases (also called Rab proteins) control various transport operations between different areas of a cell. If the transport system is disrupted, diseases such as obesity can occur. The Rab proteins work as a switch, just like the Ras proteins. In the "on" state, the high-energy molecule GTP is bound, in the "off" state, the lower-energy GDP. The cleavage of GTP to GDP is catalysed by the so-termed RabGAP proteins. In so doing, GTP is split into GDP and phosphate. The research team observed the underlying reaction in time and space for the first time with the highest possible atomic resolution.

First a snapshot, then a whole film

Using X-ray structure analysis, the researchers first determined the spatial structure of the protein complex. The data showed a finger of the amino acid arginine, and a second finger of glutamine. The arginine finger was already known from Ras. The glutamine finger is new and surprising. RabGAP penetrates into the GTP-binding pocket of Rab with both finger
'/>"/>

Contact: Klaus Gerwert
klaus.gerwert@bph.ruhr-uni-bochum.de
49-234-322-4461
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. Enzymes implicated in disease processes attack one another instead of harming body proteins
3. Synchrotron gives insight into green energy enzymes
4. Enzymes may point toward better therapies for prediabetes
5. Warwick scientists uncover how checkpoint proteins bind chromosomes
6. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
7. Unusual protein helps regulate key cell communication pathway
8. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
9. RANK protein promotes the initiation, progression and metastasis of human breast cancer
10. Protein may represent a switch to turn off B cell lymphoma
11. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many trendy ... on Facebook, Twitter, and Pinterest. The fans will have an ... lottery every week. , Moreover, the company has extended its ... Angelweddingdress homepage for more information. , Angelweddingdress is ...
(Date:1/22/2015)... 2015 Juvent Sports ( http://www.juventsports.com ) ... PGA Merchandise Show to bestow a Juvent Sports Achievement ... golfer, Arlene McKitrick. The award commemorated and congratulated McKitrick ... win. She won her first amateur tournament in 1979 ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... La Jolla, Calif. (PRWEB) January 22, 2015 ... and Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen ... (CHI) for their leadership in advancing biotechnology, biomedical ... Mitchell, Bonilla and Olsen each received the “2014 ...
(Date:1/22/2015)... 2015 Payday lending practices in four ... cause financial distress to the states that permit them, ... University’s Center on Race and Wealth. , While they ... payday loans at the same time substantially depress economic ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... KeepEmCookin.com highlighted in June 2009 issue of Pregnancy BALTIMORE, ... its "Website We Can,t Live Without" for June 2009.The ... bed rest and preterm labor that is current, concise, ... up-to-date and reliable, and then gives women a place ...
... Health Care Costs And Prevents 164,000 Emergency Room ... 20 Funding for poison control services has ... Beginning in September of 2009, California will become ... emergency poison control services for residents or medical ...
... Orasi Medical, Inc. announced today that it has completed ... use this capital to expand the development and use ... markets. Pharmaceutical companies will use this test to determine ... diseases. Orasi is currently in discussions with several pharmaceutical ...
... to Urge Families to Take Action against Atherosclerosis , ... AZN ) today kicks off the 2009 JUNTOS CONTRA ... state-of-the-art, multisensory, motion simulator that helps people visualize atherosclerosis ... For a second year in a row, AstraZeneca has ...
... nearly $2.4 million over the last eight yearsSAN ... Bros. is proud to announce that the Company, ... $339,537 to benefit the American Heart Association. Since ... for the American Heart Association.(Photo: http://www.newscom.com/cgi-bin/prnh/20090520/LA20346 ...
... US Farms, Inc. (Pink Sheets: USFM), announced today ... Products Association. Founded in 1936, the Natural Products Association ... representing more than 10,000 retailers, manufacturers, wholesalers and distributors ... aids. The Natural Products Association,s mission is to advocate ...
Cached Medicine News:Health News:Pregnancy Magazine Names KeepEmCookin.com its 'Website We Can't Live Without' 2Health News:Governor Eliminates California's Poison Control Service 2Health News:AstraZeneca, the National Alliance for Hispanic Health and LULAC Join Forces to Promote Needed Heart Health Education in Hispanic Communities 2Health News:AstraZeneca, the National Alliance for Hispanic Health and LULAC Join Forces to Promote Needed Heart Health Education in Hispanic Communities 3Health News:AstraZeneca, the National Alliance for Hispanic Health and LULAC Join Forces to Promote Needed Heart Health Education in Hispanic Communities 4Health News:AstraZeneca, the National Alliance for Hispanic Health and LULAC Join Forces to Promote Needed Heart Health Education in Hispanic Communities 5Health News:Stater Bros. Raises $339,537 for American Heart Association 2Health News:Stater Bros. Raises $339,537 for American Heart Association 3Health News:US Farms, Inc. Announces Membership to Natural Products Association 2
(Date:1/23/2015)... 2015  Now available for sale, The Armor1 Ankle Roll ... ankle sprains by cushioning the ankle from an inversion ... the outside of any shoe type and allows the ... offering protection against sprains. With customers in physical therapy, ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
(Date:1/22/2015)... 2015  ViewRay™, a privately held medical device company, announced ... agreement with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) ... treatment of cancer in Japan . ... first and only MRI-guided radiation therapy system that images ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... Defibrillator was designed to be as easy ... and shares many of its features, including ... Philips HeartStart Home Defibrillator is an automated ... home use by untrained users. Although small ...
... imaging and an extraordinary combination of ... choice for the multi-specialty clinical environment. ... SSD-4000s software and hardware allows you ... exams while achieving high-quality results., ,The ...
... is a cost-effective, office-based ultrasound system. It ... quality of our more expensive ProSound models ... maneuvering in small exam rooms., ,The SSD-3500 ... data management system (iDMS) enables easy storage ...
Inquire...
Medicine Products: