Navigation Links
Fast Heart Rate Warns of Obesity, Diabetes

And those conditions take toll on the heart, study says

THURSDAY, Dec. 11 (HealthDay News) -- A too-fast heartbeat in early adulthood is a warning sign for increased risk of cardiovascular problems decades later on, a Japanese study suggests.

The study of 614 residents of a rural farming community in southwestern Japan found that a heart rate greater than 80 beats a minute during a first examination in 1979 predicted the development of obesity and diabetes, which contribute to heart problems.

The findings, from Kurume University School of Medicine, were published online Dec. 11 in the American Journal of Hypertension.

A fast heart rate is a signal from the sympathetic nervous system, a part of the autonomic nervous system, which is the body's automatic pilot that governs instinctive responses, explained Mercedes Carnethon, assistant professor of preventive medicine at Northwestern University's Feinberg School of Medicine. She found the same rapid heartbeat association in a group of Americans she studied.

"If someone has a consistently fast heart rate, it is because of increased input from the sympathetic part of the nervous system because the body is preparing to respond to stress," Carnethon said. "There is an increase in levels of blood glucose -- essentially because the body is storing energy to prepare for fight or flight, so that predisposes to diabetes."

Carnethon's study followed Chicago residents even longer than the Japanese researchers. "Over a 33-year follow-up, we showed that people with a higher heart rate were more likely to have Medicare claims for diabetes-related conditions," she said.

There's a possible clinical use for the findings, Carnethon said, since doctors routinely listen to the heart rate.

"It is a very simple measure, regularly taken in clinical practice, that could be potentially useful because it suggests where there might be a higher incidence of heart risk and mortality," she said. "It is a first stage to alert the clinician that there might be something worth investigating."

The similar findings in the two studies half a world apart are noteworthy, Carnethon said. "We are always happy to see findings replicated by different investigators in different settings," she said.

Meanwhile, researchers are reporting a different built-in mechanism that protects a lucky few individuals from heart disease -- a genetic mutation that seems to reduce blood levels of the fats called triglycerides.

The mutation was found in members of the Old Order Amish community in Pennsylvania, said the lead investigator, Toni I. Pollin, an assistant professor of medicine at the University of Maryland School of Medicine.

Pollin and her colleagues looked through the complete genetic complement of more than 800 members of the Amish community. "We looked at genes involved in the response to dietary fat," she said. "One region came up strong on chromosome 11. This genetic marker was not too far from a cluster of genes involved in lipid metabolism."

The researchers closed in on one gene, designated APOC-3, according to a report in the Dec. 12 issue of the journal Science. That gene makes a protein that inhibits the breakdown of triglycerides. About 5 percent of the Amish in the study had a mutated form of the gene that limited production of the protein, and so they had low blood lipid levels.

"It is an apparent cardioprotective mechanism," Pollin said. "It raises the hope that by decreasing production of APOC-3 it could potentially be therapeutic."

It's possible that a drug designed to target the gene could be used to reduce levels of blood fats and thus reduce coronary risk, Pollin said.

The mutation has not been found outside the Amish community, Pollin said. "We have looked at 200 healthy individuals and have not found it, she said.

More information

The autonomic nervous system is explained by the American Heart Association.

SOURCES: Mercedes Carnethon, Ph.D., assistant professor of medicine, Northwestern University Feinberg School of Medicine, Chicago; Toni I. Pollin, Ph.D., assistant professor of medicine, University of Maryland School of Medicine, Baltimore; Dec. 12, 2008, Science; Dec. 11, 2008, American Journal of Hypertension, online

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Heart regenerates after infarction -- first trials with mice
2. Crowded Households Raise Womens Heart Risk
3. Implantable monitor may help in managing diastolic heart failure
4. New statement outlines essentials of heart failure clinics
5. Frost & Sullivan Awards SourceOne Global Partners for Proprietary Heart Health Formulas
6. Retired Heart Surgeon Dr. Dwight Lundell Celebrates 65th Birthday by Placing First in Arizona Ironman Competition
7. Res-Q Gains Rights To Market Orosine - a Breakthrough, Patented, Natural Heart Supplement That Cardiologists Are Calling the Ultimate Cardio Protection Against Heart Attacks, Strokes and Heart Failure.
8. Estero Urgent Care to Hold A Matter Of Heart Health Fair, a Free Event Focusing on Heart Disease Prevention to be Held on December 21st at Estero Community Park
9. Cancer to Surpass Heart Disease as Worlds Leading Killer
10. Top Heart Programs Choose Safety of Medivances Non-Invasive Arctic Sun(R) for Therapeutic Hypothermia
11. Mediterranean Diet Enriched With Nuts Cuts Heart Risks
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... With Fall ... heat styling tool for this month’s Facebook Hair Styler Contest. , Enter to win! ... Contest Image Answering: What Is Your Favorite Hair Style? , 3. Follow us on ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... for children with autism, PediaPlex , a Southlake, Texas, child development and ... ABA Therapy and educating military families about their options for receiving this ...
(Date:10/13/2015)... ... 2015 , ... Bambeco, Inc., the premier brand for designing, ... closed on a $20.5 million funding round led by ABS Capital Partners, a ... continued rapid growth and expansion, broaden the Company’s product offerings, and expand its ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... Vereb has been named the organization’s Executive Vice President of Operations, and three ... to key leadership roles in the company. , Debbie Vereb’s appointment to Executive ...
(Date:10/13/2015)... ... October 13, 2015 , ... Curly Hair Solutions® is thrilled ... Toronto, an exhibition featuring the newest products and services to hit the market ... be more excited to unveil their recent partnership with Trade Secrets, a leading ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 2015 Given the intricacy of the ... to deliver an ophthalmic drug effectively to a specific ocular ... ocular drug delivery. These include dilution of a drug by ... conjunctiva and drug permeation issues with respect to the cornea, ... eye drops, is lost due to the aforementioned barriers. ...
(Date:10/12/2015)... N.J. , Oct. 12, 2015  Shareholder rights ... a securities fraud class action complaint was filed in ... Jersey.  The complaint alleges that officers and directors of ... Act of 1934 between September 15, 2015 and October ... about Amicus Therapeutics, business prospects.  Amicus is a biopharmaceutical ...
(Date:10/12/2015)... 12, 2015  Millions of smokers worldwide have used ... of tobacco. An April 2015 study released ... showed electronic cigarettes to be up to 95 percent ... a decade after the technology was first introduced the ... --> --> Palm ...
Breaking Medicine Technology: