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Date:4/30/2008

s in women at least 14 years of age, who have no known contraindications to oral contraceptive therapy and have achieved menarche. YAZ should be used for the treatment of acne only if the patient desires an oral contraceptive for birth control.

Women who would like to learn more about YAZ should call the toll-free number 1-888-84-BAYER or visit http://www.yaz-us.com.

Important Information About YAZ

YAZ contains 3 mg of the progestin drospirenone that has anti-mineralocorticoid activity including the potential for hyperkalemia in high-risk patients, comparable to a 25-mg dose of spironolactone.

YAZ should not be used in patients with conditions that predispose to hyperkalemia (ie, renal insufficiency, hepatic dysfunction, and adrenal insufficiency). Women receiving daily, long-term treatment for chronic conditions or diseases with medications that may increase serum potassium should have their serum potassium levels checked during the first treatment cycle. Medications that may increase serum potassium include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs.

Patients should be counseled that OCs do not protect against HIV infection and other sexually transmitted diseases. The use of oral contraceptives is associated with increased risks of several serious conditions including venous and arterial thrombotic and thromboembolic events (such as myocardial infarction, thromboembolism, stroke), hepatic neoplasia, gallbladder disease, and hypertension. Cigarette smoking increases the risk of serious cardiovascular side effects; women who take OCs are strongly advised not to smoke.

About Bayer HealthCare Pharmaceuticals Inc.

Bayer HealthCare Pharmaceuticals Inc. is the U.S.-based pharmaceuticals operation of Bayer HealthCare LLC, a division of Bayer AG. One of the world's l
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SOURCE Bayer HealthCare Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
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