Navigation Links
Farnesoid X receptor regulates cystathionase
Date:5/13/2009

The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance.

In the present study the analysis of the human Cystathionase gene promoter demonstrates the presence of an inverted repeat sequence. Administration of an FXR ligand to carbon tetrachloride treated mice protected against down-regulation of Cystathionase expression, increased hydrogen sulphide generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused livers.

A research article to be published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Barbara Renga and her colleagues in the University of Perugia, Italy used luciferase transfection assay, Electrophoretic Mobility Shift Assay (EMSA), Chromatin Immunoprecipitation Assay and Real-Time PCR to confirm the role of FXR in the regulation of CSE transcription.

The molecular mechanism of the CSE activation by FXR was revealed by identifying a sequence in the 5' flanking region of CSE gene containing a potential IR1 binding site. Co-transfection of HepG2 cells with luciferase reporter vector containing four copies of this putative IR1 resulted in transactivation of the CSE promoter in presence of an FXR ligand, while the mutation of the IR1 binding site abrogates this response. The functionality of this IR1 site was also confirmed by EMSA and CHIP assay.

In the normal liver the CSE expression was significantly increased when mice were fed a chow diet supplemented with 5 mg/kg body weight of 6E-CDCA while the FXR ligand failed to up-regulate CSE mRNA expression in FXR knock-out mice.

Contraction of presinusoidal myofibroblasts has relevance in regulating intrahepatic resistance and short term administration
'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
3. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
4. Pharmacopeia Acquires Selective Androgen Receptor Modulator (SARM) Program from Bristol-Myers Squibb
5. Food restriction increases dopamine receptor levels in obese rats
6. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
7. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
8. Exelixis to Receive Milestone Payment From Bristol-Myers Squibb for Achievement of Liver X Receptor Agonist Development Milestone
9. Receptor protein appears to be key in breakdown of kidney filtration
10. Cell-death receptor links cancer susceptibility and inflammation
11. Food peptides activate bitter taste receptors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... September 19, 2014 A McLean ... Circuit Court (case 14-L-1175), following a failed hip replacement ... is suing DePuy Orthopaedics Inc. and Johnson & Johnson ... Flood Law Group, a nationally known personal injury law ... following developments in litigation involving defective hips. , According ...
(Date:9/19/2014)... together with friends is a big part of being young, ... to look graceful without spending a large sum of money. ... fashionable prom dresses. Apart from this, it has launched a ... Now, all the global consumers can enjoy a discount, up ... , The company’s chief executive officer says, “We are ...
(Date:9/18/2014)... (PRWEB) September 19, 2014 When Mary Ann Thompson ... the couple, who live in Bali, Indonesia with their son, Isaac, ... The two met at Mercy College in 2001 when Thompson ... Nikel, who was a graduate student at the time, was French ... from Jamaica and migrated to the United States when she was ...
(Date:9/18/2014)... cancer experts around the world have issued a plea ... carry out high quality research and clinical trials for ... fatal and for which there are many unanswered questions. ... management of advanced breast cancer, published simultaneously in the ... Annals of Oncology [1] today (Friday), the experts ...
(Date:9/18/2014)... 2014 A jacket is a hip- ... typically has sleeves, and fastens in the front or ... tighter-fitting, and less insulating than a coat, which is ... protective clothing. Today, Fecbek, a well-known clothing manufacturer and ... men’s jackets; all these items are offered at extremely ...
Breaking Medicine News(10 mins):Health News:Flood Law Group Comments on Recent Hip Replacement Lawsuit 2Health News:With New Semester Under Way, LunaDress Unveils The Most Fashionable Prom Dresses 2Health News:For The First Time in Over a Decade Mercy College Alumni Marry at College 2Health News:Experts issue plea for better research and education for advanced breast cancer 2Health News:Experts issue plea for better research and education for advanced breast cancer 3Health News:Experts issue plea for better research and education for advanced breast cancer 4Health News:Experts issue plea for better research and education for advanced breast cancer 5Health News:Cool Jackets Are For Sale At Fecbek.com 2
... Over 50% of the teenagers who suffer from eating disorders do ... may even be for over six months. As many as 1,000 ... said that they are capable of recognizing such disorders in their ... noticed by their parents. ,The research was conducted ...
... Geneva University Hospital, tested the new technique of methicillin-resistant ... ,He said that it could reduce // ... the money spent in order to deal with these ... bacteria DNA in the patient swabs. ,This ...
... researchers at Washington University has highlighted a new combination ... treatment modality claims to even restore normal breathing in ... models have revealed promising findings, the results of which ... The dual drug combination is believed to enhance airway ...
... Custom officials in Hong Kong have been put on high ... among birds and poultry. // The officials have been instructed ... and poultry into the territory. ,The proposed move ... trafficking of birds. The health chief of the former British ...
... Health Foundation, even as the UK seeks to win the football World ... out how much importance men give to the game. Evaluations will be ... their jobs just for the pleasure of watching the game, and as ... or participate in the game itself. ,The Health Charity ...
... a common gene which gives rise to Alzheimer's disease, according ... Medicine. This could also serve to conclusively prove that it ... 1,000 families in which the Alzheimer's disease is prevalent in ... with regard to the disease was sought to be established ...
Cached Medicine News:Health News:Eating Disorders Among Children Are Widespread 2Health News:Bird Flu Threat Prompts Tightened Security Across Hong Kong Border 2
(Date:9/18/2014)... YORK , Sept. 18, 2014 This BCC Research ... share of major players, market growth and size, and opportunities ... trends and revenue through 2018. Patent analysis in the report ... as the U.S., Europe and ... to: - Define and discuss the global medical device technologies ...
(Date:9/18/2014)... Sept. 18, 2014   Fruit Street Health ... initial seed round of funding. The ... by a series of individual investors, the majority of ... in the initial round are; Houston Cardiology Consultants ... Urologist Stacy Childs, Rapha Family Medicine Practice Owner ...
(Date:9/18/2014)... 2014  ADM Tronics Unlimited, Inc. (OTCQB: ADMT) ... its corporate Advisory Board for business development. ... Harvard Medical School and Visiting Professor at the ... Masters degree in Electronics Engineering and his Ph.D. ... Bologna. After spending a year as a visiting ...
Breaking Medicine Technology:Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 2ADM Tronics Appoints Gianluca DeNovi, Ph.D. To Advisory Board 3
... ADDISON, Texas, March 11, 2011 U LURUInc.(NYSE ... the development of a portfolio of wound management and oral ... NYSE Amex LLC (the "Exchange") advising ULURU that it is ... continued listing standards under Section 1003 of the Exchange,s Company ...
... (Nasdaq: NVAX ), a clinical-stage vaccine company, announced ... be presenting at the ROTH 23rd Annual OC Growth Stock ... at The Ritz Carlton, Laguna Niguel, CA.  A live audio-only ... Company website at www.novavax.com under Investors/Events, and a ...
Cached Medicine Technology:ULURU Inc. Receives Letter of Non-Compliance From NYSE Amex 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: