Navigation Links
Family ties: Relationship between human and zebrafish genomes
Date:4/17/2013

Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. Their study highlights the importance of zebrafish as a model organism for human disease research.

The team developed a high-quality annotated zebrafish genome sequence to compare with the human reference genome. Only two other large genomes have been sequenced to this high standard: the human genome and the mouse genome. The completed zebrafish genome will be an essential resource that drives the study of gene function and disease in people.

At first glance, Zebrafish may seem to be a strange comparator to humans, but like us they are vertebrates and we share a common ancestor. They are remarkably biologically similar to people and share the majority of the same genes as humans, making them an important model for understanding how genes work in health and disease.

"Our aim with this project, like with all biomedical research, is to improve human health," says Dr Derek Stemple, senior author from the Wellcome Trust Sanger Institute. "This genome will allow researchers to understand how our genes work and how genetic variants can cause disease in ways that cannot be easily studied in humans or other organisms."

Zebrafish research has already led to biological advances in cancer and heart disease research, and is advancing our understanding of muscle and organ development. Zebrafish have been used to verify the causal gene in muscular dystrophy disorders and also to understand the evolution and formation of melanomas or skin cancers.

"The vast majority of human genes have counterparts in the zebrafish, especially genes related to human disease," says Professor Jane Rogers, senior author formerly at The Genome Analysis Centre. "This high quality genome is testament to the many scientists who worked on this project and will spur biological research for years to come.

"By modeling these human disease genes in zebrafish, we hope that resources worldwide will produce important biological information regarding the function of these genes and possibly find new targets for drug development."

The zebrafish genome has some unique features, not seen in other vertebrates. They have the highest repeat content in their genome sequences so far reported in any vertebrate species: almost twice as much as seen in their closest relative, the common carp. Also unique to the zebrafish, the team identified chromosomal regions that influence sex determination.

The zebrafish genome contains few pseudogenes - genes thought to have lost their function through evolution - compared to the human genome. The team identified 154 pseudogenes in the zebrafish genome, a fraction of the 13,000 or so pseudogenes found in the human genome.

"To realize the benefits the zebrafish can make to human health, we need to understand the genome in its entirety both the similarities to the human genome and the differences," says Professor Christiane Nsslein-Volhard, author and Nobel laureate from the Max Planck Institute for Developmental Biology. "Armed with the zebrafish genome, we can now better understand how changes to our genomes result in disease."

"This genome will help to uncover the biological processes responsible for common and rare disease and opens up exciting new avenues for disease screening and drug development," adds Dr Stemple.


'/>"/>

Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Related medicine news :

1. Dr. Gary McClain of JustGotDiagnosed.com Speaking at Inhibitor Family Camp
2. Six Tips for Preventing Tooth Erosion in Kids from Family Tree Dental Group
3. Lung Cancer Asbestos Victims Now Urges Family Members Of Lung Cancer Victims To Ask If They Were Exposed To Asbestos At Work And To Call Them If The Answer Is Yes
4. Mesothelioma Victims Center Now Urges Victims Of Mesothelioma Or Family Members To Call Them For The Names Of The Most Skilled Mesothelioma Law Firms-Get Compensated
5. Leesburg VA Dentist Dr. Gary S. Nelson Introduces Implant Crowns at Leesburg Family Dentistry
6. Northampton MA Dentist Dr. Teddi Olszewski is the Newest Doctor to Offer Biolase at Northampton Family and Cosmetic Dentistry
7. Southport Family Dental Celebrates it's 14th Year as a Preferred Provider of Invisalign Braces
8. Defining the scope of skills for family medicine residencies
9. Avamere Family of Companies Acquires Six Transitional Care Facilities, Expands Eastward into New Post-Acute Markets.
10. Penn State to Offer Human Development and Family Studies Degree Online
11. Mesothelioma Victims Center Now Urges Family Members Dealing With A Loss To Mesothelioma To Call Them For The Names Of The Best Mesothelioma Law Firms-Get Compensated
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... EXTON, Pa. , Oct. 10, 2017   ... leader in innovative solutions for injectable drug administration, today ... of West,s ID Adapter for improving the intradermal administration ... the Fourth Skin Vaccination Summit in May 2017 by ... Team Lead, Polio Department, World Health Organization (WHO), and ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/4/2017)...  According to the Centers for Disease Control and Prevention (CDC), ... Urgent Care is helping communities across Massachusetts , ... offering no-cost* flu shots through the end of the month. ... regulations. ... a flu shot is by the end of October, according to the ...
Breaking Medicine Technology: