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Family ties: Relationship between human and zebrafish genomes
Date:4/17/2013

Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. Their study highlights the importance of zebrafish as a model organism for human disease research.

The team developed a high-quality annotated zebrafish genome sequence to compare with the human reference genome. Only two other large genomes have been sequenced to this high standard: the human genome and the mouse genome. The completed zebrafish genome will be an essential resource that drives the study of gene function and disease in people.

At first glance, Zebrafish may seem to be a strange comparator to humans, but like us they are vertebrates and we share a common ancestor. They are remarkably biologically similar to people and share the majority of the same genes as humans, making them an important model for understanding how genes work in health and disease.

"Our aim with this project, like with all biomedical research, is to improve human health," says Dr Derek Stemple, senior author from the Wellcome Trust Sanger Institute. "This genome will allow researchers to understand how our genes work and how genetic variants can cause disease in ways that cannot be easily studied in humans or other organisms."

Zebrafish research has already led to biological advances in cancer and heart disease research, and is advancing our understanding of muscle and organ development. Zebrafish have been used to verify the causal gene in muscular dystrophy disorders and also to understand the evolution and formation of melanomas or skin cancers.

"The vast majority of human genes have counterparts in the zebrafish, especially genes related to human disease," says Professor Jane Rogers, senior author formerly at The Genome Analysis Centre. "This high quality genome is testament to the many scientists who worked o
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Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

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