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Family history of colorectal cancer linked with reduced risk of cancer recurrence
Date:6/3/2008

leagues.

If these intriguing findings are validated in other studies, family history may well become a new prognostic factor in colorectal cancer. Should this be the case, genome-wide association studies and tumor gene expression profiling studies will be warranted to identify germline and tumor-specific genetic features associated with a family history of colorectal cancer and favorable outcome following adjuvant chemotherapy.

Over the past 2 decades, some of the first major molecular genetics inroads were achieved through careful study of patients with a strong family history of colorectal cancer, Dr. Pasche writes. The study by Chan et al suggests that family history of colorectal cancer will lead to the identification of novel genetic features predictive of response to chemotherapy. Familial colorectal cancer may therefore confirm its role as a genetics treasure trove for medical discovery.

(JAMA. 2008;299[21]:2564-2565. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including financial disclosures, funding and support, etc.


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