Navigation Links
Family history of colorectal cancer linked with reduced risk of cancer recurrence
Date:6/3/2008

Among patients with advanced colon cancer receiving treatment that includes chemotherapy, a family history of colorectal cancer is associated with a significant reduction in cancer recurrence and death, with the risk reduced further by having an increasing number of affected first-degree relatives, according to a study in the June 4 issue of JAMA.

Approximately 16 percent to 20 percent of patients with colorectal cancer have a first-degree relative with colorectal cancer. Beyond rare but highly penetrant hereditary colorectal cancer syndromes, numerous studies have demonstrated that a history of colorectal cancer in a first-degree relative increases the risk of developing the disease by approximately 2-fold. However, the influence of family history on cancer recurrence and survival among patients with established colon cancer remains uncertain, the authors write.

Jennifer A. Chan, M.D., M.P.H., of the Dana-Farber Cancer Institute, Boston, and colleagues examined the association of family history of colorectal cancer with recurrence and survival of 1,087 patients with stage III colon cancer who were receiving supplemental chemotherapy. Patients provided information on family history of colorectal cancer at the beginning of the study, and were followed up until March 2007 for cancer recurrence and death (median [midpoint] follow-up, 5.6 years).

Among the 1,087 participants, 195 (17.9 percent) reported a family history of colorectal cancer in 1 or more first-degree relatives. The researchers found that a family history of colorectal cancer was associated with a significant reduction in the risk of cancer recurrence or death. Compared with patients without a family history, those with a family history had a 28 percent lower risk for cancer recurrence or death, which occurred in 57 of 195 patients (29 percent) with a family history of colorectal cancer compared with 343 of 892 patients (38 percent) without a family history.

Examining just the risk for cancer recurrence, patients with a family history of colorectal cancer had a 26 percent reduced risk compared with patients without a family history. Cancer recurrence occurred in 27 percent of patients with a family history of colorectal cancer and 35 percent of patients without a family history. The reduced risk of death for patients with a family history of colorectal cancer was 25 percent.

The apparent benefit associated with family history was stronger with an increasing number of affected family members. Compared with participants without a family history of colorectal cancer, participants with two or more affected relatives had a 51 percent lower risk for cancer recurrence or death.

Beyond rare, well-characterized hereditary colorectal cancer syndromes, our data support the hypothesis that a relatively common though less penetrant genetic predisposition may not only influence colorectal cancer risk but also patient survival. This finding may reflect a distinct underlying molecular and pathogenic mechanism in cancers that develop in the setting of a common (i.e., sporadic) family history, the researchers write. Further studies are needed to more fully elucidate potential mechanisms by which a common family history may influence the outcome for patients with colorectal cancer.

(JAMA. 2008;299[21]:2515-2523. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


Editorial: Familial Colorectal Cancer - A Genetics Treasure Trove for Medical Discovery

In an accompanying editorial, Boris Pasche, M.D., Ph.D., of the Northwestern University Feinberg School of Medicine, Chicago, and Contributing Editor, JAMA, comments on the results of the study by Chan and colleagues.

If these intriguing findings are validated in other studies, family history may well become a new prognostic factor in colorectal cancer. Should this be the case, genome-wide association studies and tumor gene expression profiling studies will be warranted to identify germline and tumor-specific genetic features associated with a family history of colorectal cancer and favorable outcome following adjuvant chemotherapy.

Over the past 2 decades, some of the first major molecular genetics inroads were achieved through careful study of patients with a strong family history of colorectal cancer, Dr. Pasche writes. The study by Chan et al suggests that family history of colorectal cancer will lead to the identification of novel genetic features predictive of response to chemotherapy. Familial colorectal cancer may therefore confirm its role as a genetics treasure trove for medical discovery.

(JAMA. 2008;299[21]:2564-2565. Available pre-embargo to the media at www.jamamedia.org)

Editors Note: Please see the article for additional information, including financial disclosures, funding and support, etc.


'/>"/>

Contact: Robbin Ray
617-632-4090
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Work-Family Conflict Dogs Air Force Women After Deployment
2. Work-Family Conflict Dogs Air Force Women After Deployment
3. Isolation of a new gene family essential for early development
4. Lake Elsinore Family Caregiver Receives Free Power Wheelchair From The SCOOTER Store
5. Family-based treatment more effective than supportive psychotherapy in treating bulimia
6. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
7. BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank
8. Regional Center of Orange County Expands Family Support Resources to Meet Growing Needs
9. The Arthur M. Blank Family Foundation Pushes for Pre-K Expansion in Georgia
10. Family History Has Strong Effect on Cardiac Risk
11. Childs Flu Shot Helps Whole Family
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... and clinical practice of radiosurgery, is recognizing five medical residents and students for ... stereotactic body radiotherapy (SBRT). The awards will be presented at the 2016 SRS/SBRT ...
(Date:5/24/2016)... ... 24, 2016 , ... Bio-Logic Aqua® Research Water Life Science® ... a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss healthier lifestyles, especially ... 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated to her career ...
(Date:5/24/2016)... ... May 24, 2016 , ... In light of recent ... of the potential of contaminated well water throughout the Houston area. , Heavy floodwaters ... well water that’s exposed to contaminants. Residents may not even be aware of the ...
(Date:5/24/2016)... ... 2016 , ... The Dream Builders Project, a 501(c)3 nonprofit organization based in ... in Tijuana, Mexico on Saturday, May 21st. The volunteers took the children out for ... More than 15 volunteers traveled from Los Angeles to Tijuana, Mexico for the day ...
(Date:5/24/2016)... Greenwich, Connecticut (PRWEB) , ... May 24, 2016 ... ... of Lyme and tick-borne disease research and education, today announced that it has ... and CEO of the Bonnie J. Addario Lung Cancer Foundation (ALCF) in San ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... , May 23, 2016 Diplomat Pharmacy, Inc. (NYSE: ... Fellowship and Internship programs. The hands-on learning experience is ... The full-time, paid Fellowship and Internship ... . Fellows and interns are provided optional housing ... Flint at the Riverfront Residence Hall to ...
(Date:5/23/2016)... The World Health Organization (WHO) expanded the Intended ... adolescents aged 13 years, and above. Effective immediately, the PrePex ... and adolescent males in the 14 priority countries in Southern ... first male circumcision device to receive WHO Prequalification on 31 ... said: " The expanded use of PrePex ...
(Date:5/23/2016)... 2016 The global  reprocessed medical ... by 2022, according to a new study by Grand ... coupled with the lack of centralized support for waste ... the demand for reprocessed medical devices market. Additionally, the ... that of the original device is the high impact ...
Breaking Medicine Technology: