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Family history of alcoholism affects response to drug used to treat heavy drinking
Date:9/19/2007

the authors, notes that When studied in large groups, naltrexone appears to have a rather small effect upon the ability to reduce drinking or remain abstinent from alcohol. However, there is growing evidence that there are subgroups of patients who show substantial benefit from naltrexone, even when naltrexone fails to work in the overall trial (see Gueorguieva R et al. Biol Psychiatry. 2007 Jun 1;61(11):1290-5). According to Suchitra Krishnan-Sarin, Ph.D., the lead author, The results suggest that family history of alcoholism may be an important predictor of clinical response to naltrexone and could potentially be used to guide clinical practice. Dr. Krystal agrees, These data suggest that family history might influence the optimal dosing of naltrexone and the nature of the clinical response. Their hope is that these findings ultimately can contribute to a better treatment experience for some who are seeking to end their battle with alcohol.


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Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

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