The study appears in the current issue of the journal Circulation: Cardiovascular Genetics.
"We have to be careful not to draw conclusions for families with arrhythmias caused by different mutations," lead researcher Dr. Eline Nannenberg, a clinical geneticist at the Academic Medical Center in Amsterdam, said in a journal news release.
"However, this new data can guide screening. In LQTS1, we advise starting genetic and heart screening of first-degree family members (children, siblings, parents) at a very young age," Nannenberg added.
Female patients who have Brugada syndrome but no symptoms may not need invasive treatment for the first 30 years of life, but should follow standard prevention measures, such as fighting fever, according to the researchers.
In people with SCN5a-overlap syndrome, it may be possible to delay implantation of a pacemaker or implantable cardioverter-defibrillator (ICD) until after age 5, they noted.
The Heart Rhythm Society has more about heart rhythm disorders.
-- Robert Preidt
SOURCE: Circulation: Cardiovascular Genetics, news release, Feb. 28, 2012
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