Navigation Links
Family Tree May Aid Treatment of Inherited Heart Disorders
Date:2/28/2012

TUESDAY, Feb. 28 (HealthDay News) -- Researchers who used family trees dating back to 1811 to estimate the death risk for people with inherited heart rhythm disorders say their findings can help doctors determine when to screen and treat today's patients with these disorders.

Sudden cardiac death can occur in apparently healthy people due to heart rhythm disorders. Genetic testing can identify people with an inherited heart rhythm disorder (arrhythmia), but that raises questions about how and when to treat children who may not yet be experiencing symptoms, which can take years to develop.

In the study, researchers used Dutch archives to reconstruct the family trees for patients with inherited heart conditions, including long QT syndrome, SCN5a-overlap syndrome, CPVT and Brugada syndrome. The arrhythmia-associated gene mutations examined in the study are rare. However, the children of people who carry one of these mutations have a 50 percent chance of inheriting it.

The investigators were able to identify age ranges that were associated with an increased risk of death among people who had the mutations but had not yet been diagnosed or treated for the condition.

Among the findings:

  • The death risk for people with long QT syndrome -- a condition related to sudden infant death syndrome -- was high between 1 and 19 years old, but was particularly high in the first 10 years of life for those with a specific mutation (LQTS1). The risk of death for people with two other mutations (LQTS2 and LQTS3) didn't significantly increase until they were teens or adults.
  • For people with SCN5a-overlap syndrome, death risk started to rise at age 5 and became significant between ages 10 to 59, with a peak between ages 20 to 39. People with this condition have a gene mutation that affects the way heart cells respond to the heart's internal electrical current.
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition that causes fainting, often during exercise or strong emotions. Death risk for people with this condition was highest between ages 20 to 39.
  • Brugada syndrome causes fainting and a rapid heart rhythm that can lead to sudden cardiac death. The risk of death for people with this condition was highest between ages 40 to 59. Males were at greatest risk.

The study appears in the current issue of the journal Circulation: Cardiovascular Genetics.

"We have to be careful not to draw conclusions for families with arrhythmias caused by different mutations," lead researcher Dr. Eline Nannenberg, a clinical geneticist at the Academic Medical Center in Amsterdam, said in a journal news release.

"However, this new data can guide screening. In LQTS1, we advise starting genetic and heart screening of first-degree family members (children, siblings, parents) at a very young age," Nannenberg added.

Female patients who have Brugada syndrome but no symptoms may not need invasive treatment for the first 30 years of life, but should follow standard prevention measures, such as fighting fever, according to the researchers.

In people with SCN5a-overlap syndrome, it may be possible to delay implantation of a pacemaker or implantable cardioverter-defibrillator (ICD) until after age 5, they noted.

More information

The Heart Rhythm Society has more about heart rhythm disorders.

-- Robert Preidt

SOURCE: Circulation: Cardiovascular Genetics, news release, Feb. 28, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Rutgers study finds paid family leave leads to positive economic outcomes
2. January/February 2012 Annals of Family Medicine
3. Family Tips for Getting Fit
4. Improving family consent in organ donation could save lives
5. Key genetic error found in family of blood cancers
6. Family Tree May Affect Diagnosis Age in Some Breast Cancers
7. New research sheds light on how we see family resemblance in faces
8. November/December 2011 Annals of Family Medicine Tip Sheet
9. Drinking Risky for Women With Family History of Breast Cancer: Study
10. Girls with family history of breast disease should avoid alcohol
11. Life beyond cancer: Starting a family following treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... , ... After a year and a half of planning the Multiple Pathways of Recovery ... Pathways of Recovery Conference was held May 2 -4, 2016 at the Mystic Marriott ... together to explore the many pathways individuals use to get into and sustain their recovery. ...
(Date:5/27/2016)... ... 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield of ... 2016 honorees. The award recognizes businesswomen who excel in their fields and who ... the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and Theresa ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting at ... company to wait until March 2017 for an interest rate increase, according to Rajeev ... of Business. , “The Federal Open Market Committee (FOMC) dot charts are of interest ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: