Navigation Links
Family Tree May Affect Diagnosis Age in Some Breast Cancers
Date:12/8/2011

THURSDAY, Dec. 8 (HealthDay News) -- Some women who inherit the BRCA1 or BRCA2 breast and ovarian cancer genes from their father may be diagnosed with breast cancer nearly a decade earlier than those who inherit the genes from their mother, a new study indicates.

Researchers examined the family trees of 128 breast or ovarian cancer patients with the BRCA1 or BRCA2 mutations to determine the origins of the patients' cancer genes.

"No one had ever conducted a study to look at the parent-of-origin effects," lead researcher Dr. Iuliana Shapira said in a news release from the Monter Cancer Center in Lake Success, N.Y.

Of the breast cancer patients, 28 had paternal (from the father) and 29 had maternal (from the mother) BRCA1 mutations, while 24 had paternal and 21 had maternal BRCA2 mutations.

Of the ovarian cancer patients, six had paternal and 10 had maternal BRCA1 mutations, while seven had paternal and three had maternal BRCA2 mutations, according to the researchers.

The mean age at diagnosis was 51 (ranging from 21 to 70) for ovarian cancer and 43 (ranging from 24 to 78) for breast cancer. However, the average age of diagnosis for breast cancer patients with a maternal BRCA1 mutation was 45, compared with about 38 for those with a paternal BRCA1 mutation.

Women with a maternal BRCA2 mutation were diagnosed with breast cancer at an average age of 50, compared to 41 for those with a paternal BRCA2 mutation.

There were no significant differences in the ages that women with paternal or maternal BRCA1 or BRCA2 mutations were diagnosed with ovarian cancer.

"If this observation is duplicated in larger cohorts, the results will have important implications for recommendation of surgical risk reduction in BRCA mutation carriers," Shapira, director of cancer genetics at Monter, said in a center news release.

"That would mean that doctors might think about watching and waiting in young woman with BRCA mutations inherited from her mother's family and being more aggressive in young women who inherited the mutation from their father's side," she explained.

The study was to be presented Thursday at the San Antonio Breast Cancer Symposium. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more about BRCA1 and BRCA2.

-- Robert Preidt

SOURCE: Monter Cancer Center, news release, Dec. 8, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research sheds light on how we see family resemblance in faces
2. November/December 2011 Annals of Family Medicine Tip Sheet
3. Drinking Risky for Women With Family History of Breast Cancer: Study
4. Girls with family history of breast disease should avoid alcohol
5. Life beyond cancer: Starting a family following treatment
6. Study highlights issues faced by friends and family of the suicidal
7. African-Americans more likely to donate kidney to family member
8. Family and community medicine leader elected to Institute of Medicine
9. Relationships more important than genetic ties when deciding who cares for aging family, study finds
10. Generation Squeezed: Todays family staggering under the pressure
11. Protein family key to aging, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Family Tree May Affect Diagnosis Age in Some Breast Cancers
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference ... to read it, and some people don't like it at all. FindaTopDoc took a ... found: , Erotic literature can give readers a taste of their deepest, darkest fantasies ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has recently ... Talei has come up with a proprietary technique that he calls the AuraLyft ... have dropped. For all ages, patients can expect to look refreshed, rejuvenated, and revitalized. ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... Breast Cancer Conference from Sept. 18 to 20. , The two-day conference is ... subtype with the goal of improving patients’ lives and eliminating racial breast cancer-related ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent Care ... MD Now’s 28th facility overall and marks the urgent care center's eighth location in ... North of The Falls shopping mall. The new clinic offers a wide array of ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... Insurance offerings. With the Federal Emergency Management Agency’s (FEMA) recent update of flood ... States. In 2012, the Biggert-Waters Act was enacted to reflect the actual risk ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... , June 6, 2017  Diplomat Specialty Infusion Group, a brand ... environment to its Iowa location. ... now features an ISO 7 cleanroom—the standard needed to ... with a low level of pollutants. ... nutrition consumers and better serve our Iowa ...
(Date:6/2/2017)... June 2, 2017  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading ... announced new findings demonstrating positive biochemical outcomes related to ... One™. The data will be presented at the ERA-EDTA ... Madrid, Spain . The research ... Dialysis Network in Europe ...
(Date:5/30/2017)... , May 30, 2017 Therapix Biosciences Ltd. ... specializing in the development of cannabinoid-based drugs, today ... company overview at three upcoming scientific and investor ... LD Micro Invitational: ... Date:                     ...
Breaking Medicine Technology: