Navigation Links
Family Tree May Affect Diagnosis Age in Some Breast Cancers
Date:12/8/2011

THURSDAY, Dec. 8 (HealthDay News) -- Some women who inherit the BRCA1 or BRCA2 breast and ovarian cancer genes from their father may be diagnosed with breast cancer nearly a decade earlier than those who inherit the genes from their mother, a new study indicates.

Researchers examined the family trees of 128 breast or ovarian cancer patients with the BRCA1 or BRCA2 mutations to determine the origins of the patients' cancer genes.

"No one had ever conducted a study to look at the parent-of-origin effects," lead researcher Dr. Iuliana Shapira said in a news release from the Monter Cancer Center in Lake Success, N.Y.

Of the breast cancer patients, 28 had paternal (from the father) and 29 had maternal (from the mother) BRCA1 mutations, while 24 had paternal and 21 had maternal BRCA2 mutations.

Of the ovarian cancer patients, six had paternal and 10 had maternal BRCA1 mutations, while seven had paternal and three had maternal BRCA2 mutations, according to the researchers.

The mean age at diagnosis was 51 (ranging from 21 to 70) for ovarian cancer and 43 (ranging from 24 to 78) for breast cancer. However, the average age of diagnosis for breast cancer patients with a maternal BRCA1 mutation was 45, compared with about 38 for those with a paternal BRCA1 mutation.

Women with a maternal BRCA2 mutation were diagnosed with breast cancer at an average age of 50, compared to 41 for those with a paternal BRCA2 mutation.

There were no significant differences in the ages that women with paternal or maternal BRCA1 or BRCA2 mutations were diagnosed with ovarian cancer.

"If this observation is duplicated in larger cohorts, the results will have important implications for recommendation of surgical risk reduction in BRCA mutation carriers," Shapira, director of cancer genetics at Monter, said in a center news release.

"That would mean that doctors might think about watching and waiting in young woman with BRCA mutations inherited from her mother's family and being more aggressive in young women who inherited the mutation from their father's side," she explained.

The study was to be presented Thursday at the San Antonio Breast Cancer Symposium. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more about BRCA1 and BRCA2.

-- Robert Preidt

SOURCE: Monter Cancer Center, news release, Dec. 8, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research sheds light on how we see family resemblance in faces
2. November/December 2011 Annals of Family Medicine Tip Sheet
3. Drinking Risky for Women With Family History of Breast Cancer: Study
4. Girls with family history of breast disease should avoid alcohol
5. Life beyond cancer: Starting a family following treatment
6. Study highlights issues faced by friends and family of the suicidal
7. African-Americans more likely to donate kidney to family member
8. Family and community medicine leader elected to Institute of Medicine
9. Relationships more important than genetic ties when deciding who cares for aging family, study finds
10. Generation Squeezed: Todays family staggering under the pressure
11. Protein family key to aging, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Family Tree May Affect Diagnosis Age in Some Breast Cancers
(Date:1/22/2017)... ... , ... "Photo Cloud allows FCPX users to add favorited photos to any ... said Christina Austin - CEO of Pixel Film Studios. , To begin, select ... Presets include scenes with one, three, four or five focus points. There are five ...
(Date:1/21/2017)... ... ... Caronlab Australia, an Australian company known for health and beauty products such ... where it benefited from outstanding meetings with major retail buyers. , Caron Labs has ... this trade show, the company had the chance to demonstrate its products and provide ...
(Date:1/21/2017)... ... ... perfect set of tools for video editors that want to create the illusion of rack ... of Pixel Film Studios. , Video editors using ProDOF can add realistic depth of ... from one area into the next. ProDOF comes with 0.5 second, 1.0 second, 1.5 ...
(Date:1/21/2017)... ... January 21, 2017 , ... Phytocéane invites you to ... the rest of the world with ZANZIBAR SHOWER GEL. Inspired by the beauty of ... Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, crystal-clear shower gel ...
(Date:1/21/2017)... Rosa, CA (PRWEB) , ... January 21, 2017 ... ... announce that Redwood Family Dermatology has recently joined their multi-specialty medical ... a full range of cosmetic services. , “We’re excited to add this excellent ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... The American Pharmacists Association (APhA) is excited ... Medically Underserved Areas Enhancement Act (H.R. 592) ... was previously introduced in the 114 th session ... through pharmacists and their patient care services. ... (R-KY), G.K. Butterfield (D-NC), Tom ...
(Date:1/23/2017)... ALBANY, New York , January 23, 2017 ... Non-Invasive Prenatal Testing Market was valued at US$0.53 bn ... by expanding at a strong 17.50% CAGR between 2014 and 2022. ... - Global Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... ...
(Date:1/23/2017)... PALMA, Spain , January 23, ... a clinical-stage biopharmaceutical company focused on treatments for ... has been enrolled in the Phase IIb "CaLIPSO ... the treatment of cardiovascular calcification (CVC) in end-stage-renal-disease ... ESRD patients, in the last stage of chronic ...
Breaking Medicine Technology: