Navigation Links
Family History Ups Breast Cancer Risk Even Without BRCA Gene
Date:11/17/2008

Unknown mutations may account for increased odds, researchers say

MONDAY, Nov. 17 (HealthDay News) -- The risk of breast cancer for a woman with a strong family history is four times higher than that of the general population -- even if she does not carry one of the breast cancer-linked mutations of the BRCA gene, a new study finds.

And in women younger than age 40 without the BRCA mutations, but with a very strong family history, the risk is about 15 times higher than the general population, according to the Canadian researchers.

Over a six-year period, the researchers followed up nearly 1,500 women from 365 families who had tested negative for the so-called breast cancer gene mutations in BRCA1 and BRCA2.

The study shows that women with a strong family history but not the BRCA1 and BRCA2 mutations are still very much more at risk than the average woman, said study author Kelly Metcalfe, an associate professor of nursing at the University of Toronto.

The findings suggest there are other genetic mutations that play a role in breast cancer, Metcalfe said. She is to report the finding Monday at the American Association for Cancer Research's annual International Frontiers in Cancer Prevention Research meeting, in Washington, D.C.

About 184,000 new breast cancer cases and 40,000 breast cancer deaths are expected this year in the United States, according to the American Cancer Society.

To be included in the Canadian study, women had to have two or more relatives diagnosed with breast cancer before the age of 50 or three relatives with breast cancer at any age.

The researchers compared the rates of breast cancer among these women with a family history against rates found in the general population based on regional cancer registries.

Over the follow-up period, 15.2 of the women in the family history group would have been expected to get breast cancer, but 65 did -- a f
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Work-Family Conflict Dogs Air Force Women After Deployment
2. Work-Family Conflict Dogs Air Force Women After Deployment
3. Isolation of a new gene family essential for early development
4. Lake Elsinore Family Caregiver Receives Free Power Wheelchair From The SCOOTER Store
5. Family-based treatment more effective than supportive psychotherapy in treating bulimia
6. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
7. BlueCare(R) Family Plan, a HUSKY Health Plan from Anthem Blue Cross and Blue Shield in Connecticut, Raises Awareness, Funds and Diapers for New Haven Diaper Bank
8. Regional Center of Orange County Expands Family Support Resources to Meet Growing Needs
9. The Arthur M. Blank Family Foundation Pushes for Pre-K Expansion in Georgia
10. Family History Has Strong Effect on Cardiac Risk
11. Childs Flu Shot Helps Whole Family
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Family History Ups Breast Cancer Risk Even Without BRCA Gene
(Date:12/25/2014)... 2014 Parker & Sons, Inc. an ... and affordable quality regarding heating, cooling and plumbing services ... 2014 by the “Queen of Clean” for impressive contractor ... impressive reputation over the years for providing outstanding quality ... of contractor services for both homeowners and businesses. Linda ...
(Date:12/24/2014)... 25, 2014 AlignLife of Wauwatosa ... afford certain items. During the holiday season, AlignLife looks forward ... 70 toys," says Dr. Sara Mahalko-Leonhardt, owner of AlignLife. "It ... joy, knowing that we are able to give kids toys ... not been for the generosity of our patients." , The ...
(Date:12/24/2014)... Over 700 toys, that’s what AlignLife clinics ... smiling little faces this holiday that might not have ... donations was given to the various charities as well ... through the year. Some of the charities chosen for ... Shrine's Children's Hospitals, Toys for Tots and Crisis Nurseries, ...
(Date:12/24/2014)... Epigenetics finds applications in a large number of fields ... biology, and research for metabolic and genetic disorders. It ... used techniques for the discovery and development of cancer ... rapidly growing worldwide. In 2012, there were 14.1 million ... million people living with cancer (within five years of ...
(Date:12/24/2014)... 2014 Connie Casad, MD, a well-known ... advocate with 30 years of practice experience in Dallas, ... health benefits of dietary detoxification. The second study is ... excellent results from test patients who just completed a ... her interest in conducting the study, Dr. Casad said, ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 3Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3
... business response to global economic and social challengesNEW YORK, April ... aimed at creating new partnerships with governments, NGOs and small ... on Creating Shared Value in New York ... and the Mission of ...
... Inc. (OTC Bulletin Board: PLCSF) announced today that it expects ... the first quarter ended March 31, 2009 before the market ... host a conference call to discuss those results at 11:00 ... joined via telephone by dialing (866) 825-1708 or (617) 213-8060 ...
... 27 Cornerstone Therapeutics Inc. (NasdaqCM: CRTX), a specialty ... for respiratory disorders, today announced that it will host ... May 7, 2009, to discuss its financial results for ... also provide an update on the Company,s strategy, operations ...
... TERI, Inc., a national leader ... with autism and other developmental disabilities, today announced ... Quality Plans(TM) for families and caregivers of people ... the TERI-led International Association for Life Quality ( ...
... Group at Frost & Sullivan is pleased ... the Pharmaceutical CRM Market to be held on Tuesday, ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )2008 has ushered in a variety of ... is adopting a cautious approach, delaying and re-evaluating technology ...
... to highlight advances for chronic condition; third FDA-approved drug to come ... ... Each new treatment that becomes available is a step forward for ... National Fibromyalgia Association (NFA), which is observing Fibromyalgia Awareness ...
Cached Medicine News:Health News:Nestle Launches Major Initiatives in Nutrition, Water and Rural Development 2Health News:Nestle Launches Major Initiatives in Nutrition, Water and Rural Development 3Health News:Nestle Launches Major Initiatives in Nutrition, Water and Rural Development 4Health News:Cornerstone Therapeutics to Host First Quarter 2009 Conference Call 2Health News:Cornerstone Therapeutics to Host First Quarter 2009 Conference Call 3Health News:Cornerstone Therapeutics to Host First Quarter 2009 Conference Call 4Health News:TERI Offers Comprehensive Life Quality Plans to Families, Caregivers of People with Developmental Disabilities 2Health News:Frost & Sullivan: The Pharmaceutical Customer Relationship Management Market - What are the Emerging Trends and Opportunities? 2Health News:Frost & Sullivan: The Pharmaceutical Customer Relationship Management Market - What are the Emerging Trends and Opportunities? 3Health News:Treatment Options Increase For Millions with Fibromyalgia 2Health News:Treatment Options Increase For Millions with Fibromyalgia 3
(Date:12/24/2014)... 24, 2014 /CNW/ -   ... after Health Canada tests confirmed it contains two undeclared ... and phenylpropylmethylamine). The distributor, Empire Health Distribution of ... from retail stores across Canada . ... for weight loss and increased energy. ...
(Date:12/24/2014)... Mexico , Dec. 24, 2014  Novastem, ... of its first patient in its study for ... the American Stroke Association, ischemic strokes account for ... to enroll qualified patients in the study, entitled ... Administration of Allogeneic Mesenchymal Stem Cells and Intrathecal ...
(Date:12/24/2014)... , Dec. 24, 2014  Actavis plc (NYSE: ... Company has received a complete response letter from ... its New Drug Application (NDA) for the fixed-dose ... treatment of hypertension.   Photo - ... disappointed in the receipt of a complete response ...
Breaking Medicine Technology:"Jetfuel Superburn" recalled after Health Canada tests find undeclared drug ingredients 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4
... are problem enough for your patients. Now you ... functional treatment for foot and ankle fractures and ... A combination of prefabricated brace and open foam ... higher standards of safety. The storm can be ...
... Walker Pediatric Boot is the ... boot that offers superior comfort ... two sizes are offered thus ... will fit left or right, ...
... Bledsoe Mid-Calf Boot is a shorter ... boot designed for second degree ankle ... incision protection. The Bledsoe EZ Set ... of motion from 20 degrees of ...
... The Bledsoe Conformer Diabetic Boot features ... cocoon attached to a unique auto-molding innersole ... mid-sole insert in an aluminum shelled walking ... is designed to evenly distribute body weight ...
Medicine Products: