Navigation Links
Family History Might Improve Odds Against Colon Cancer
Date:6/3/2008

Fewer deaths, recurrences seen in those who had relatives with disease, study finds

TUESDAY, June 3 (HealthDay News) -- The genetic makeup that increases the risk of developing colorectal cancer also seems to improve the chances of survival after treatment, a new study indicates.

People with colorectal cancer who had close relatives with the malignancy were 28 percent less likely to die or to have a recurrence after treatment, according to a report in the June 4 issue of the Journal of the American Medical Association by physicians at the Dana-Farber Cancer Institute in Boston.

It is well-known that a close relative of someone with colon cancer is more likely to develop such a cancer, "which is why we recommend that patients who have a family history of colorectal cancer get routinely screened," said study author Dr. Jennifer A. Chan, an instructor in medicine at Harvard Medical School and Dana-Farber. "That is why we did this study."

The study included 1,087 people who had undergone surgery for their cancers and began drug therapy. Over an median follow-up period of 5.6 years, 29 percent of those with a family history died or had a recurrence of cancer, compared to 38 percent of those without a family history.

The reason for the difference isn't known or understood, Chan said. The researchers did try to determine whether lifestyle factors such as diet might be the reason but found no connection.

"Our study was not able to determine the cause," she said. "What we suspect is that there might be some sort of genetic trait that not only increases the risk, but also improves the prognosis for cancer patients."

The increase in survival was associated with the strength of the family history. Participants with two or more close relatives with the cancer had a 51 percent lower risk for cancer recurrence or death than those with no family history.

The immediate impact of the discovery might be to give some reassurance to people with colorectal cancer and a family history, Chan said. "What we hope is that this observation leads to further studies to understand the biological reasons," she said. "If we understand those reasons, we might be able to make better treatment decisions."

The study "could change some expectations about colorectal cancer," said Dr. Boris Pasche, director of the cancer genetics program at Northwestern University, who wrote an accompanying editorial.

"The genetics of colorectal cancer are very clear," Pasche said. "There is an increased risk for those with a family history. But we still don't know what is causing that inheritance."

On the clinical level, the study indicates that "patients with a family history of colorectal cancer might be more treatable than whose who do not," Pasche said.

"If these intriguing findings are validated in other studies, family history may well become a new prognostic factor in colorectal cancer," he wrote. "Should this be the case, genome-wide association studies and tumor gene expression profiling studies will be warranted."

More information

Learn about colorectal cancer from the U.S. National Library of Medicine.



SOURCES: Jennifer A. Chan, M.D., instructor, medicine, Dana-Farber Cancer Institute, Boston; Boris Pasche, M.D., Ph.D., director, cancer genetic program, Northwestern University, Chicago; June 4, 2008, Journal of the American Medical Association


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NARSAD researchers identify specific genes and family traits linked to mental illnesses
2. Discovery of new family of genetic mutations involved in inflammatory intestinal disease
3. Chindex and United Family Healthcare Respond to Sichuan Earthquake Disaster
4. Preschoolers in Family Child Care Homes Need More Activity
5. Family Health International Featured at Global Health Council Conference
6. National Family Month 2008 Focuses on Top Issues Facing Kids and Families Today
7. Young children with OCD benefit from family-based treatment
8. Milliman Says 2008 Medical Cost for American Family of Four Exceeds $15,600
9. Kroger and Its Family of Stores Expand Discounted Generic Drug Program
10. May/June 2008 Annals of Family Medicine tip sheet
11. Almost Family, Inc. Announces Exercise of Over-Allotment Option
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Family History Might Improve Odds Against Colon Cancer 
(Date:12/6/2016)... , ... December 06, 2016 , ... "Add realistic flares ... flicker, flash, and flare from clip to clip with high quality 4K lens flare ... 4K Jewel contains 44 lens flares filmed on the RED Dragon. Utilizing the Dragon ...
(Date:12/5/2016)... , ... December 05, 2016 , ... What: Shriners Hospitals ... the North Pole to our patients – using a video monitor and web-enabled camera. ... hospital will transform the Auditorium into a Christmas Wonderland, which is where the video ...
(Date:12/5/2016)... ... December 05, 2016 , ... Edward ... to announce the arrival of the newest Sciton laser in January 2017. The ... use tunable non-ablative and ablative wavelengths for exceptional results. Outperforming more traditional lasers, ...
(Date:12/5/2016)... ... ... For many years, Andrew G. Zubinas has accumulated over 130 ... the Lithuanian language and its poetry inspired him in writing “ Forest ... all aspects of a living, breathing forest where nothing ever stays the same. His ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... networking and relationship-marketing firm, announced today that nominations will be accepted from ... Executive® (ISE®) Central Awards. , Awards include the Information Security Executive® of ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Research and Markets has announced the addition of the ... Biochemical Research, Disease Diagnostics), End User (Academic & Research Institutes, Pharmaceutical ... their offering. ... The western blotting market is ... Million in 2016, growing at a CAGR of 4.9%. ...
(Date:12/5/2016)...   BIOTRONIK today announced the first patients ... the safety and feasibility of performing the minimally invasive ... BioMonitor 2 is an insertable cardiac remote monitor ... a patient,s skin to help physicians accurately detect and ... a leading cause of stroke and heart failure. BioMonitor ...
(Date:12/5/2016)... R.I. , Dec. 5, 2016  CVS Health, ... it has received a perfect score of 100 percent ... consecutive year. The CEI is an annual national benchmarking ... to LGBT equality, administered by the Human Rights Campaign ... the rich diversity that our colleagues, customers and suppliers ...
Breaking Medicine Technology: