Navigation Links
Family History May Add to Alzheimer's Puzzle
Date:7/29/2008

Genes play only a part of underlying risk for dementia, study suggests

TUESDAY, July 29 (HealthDay News) -- The gene most often associated with Alzheimer's disease doesn't provide a complete picture of overall risk, according to researchers who analyzed family histories of the disease.

Previous research has shown that people with the E4 variant of the APOE gene have a greater risk of developing Alzheimer's, but this new Duke University Medical Center-led study is one of only a few to examine the role of both APOE and family history together.

"We've learned that APOE genotype does not tell the whole genetic story. Other genes may be acting independently of APOE to influence someone's risk for developing the disease," lead investigator Kathleen A. Welsh-Bohmer, director of Duke's Bryan Alzheimer's Disease Research Center, said in a Duke news release.

The study included more than 5,000 people in Cache County, Utah, who were 65 and older when they were enrolled in the study in 1995. About 3,000 of the participants who provided DNA and details about their family history of Alzheimer's were grouped according to the family history of the disease and whether they had the APOE E4 variant.

"Over an average of seven and a half years of observation, the people who experienced the most significant cognitive decline had a family history of the disease and one or more copies of APOE E4," Kathleen M. Hayden, an assistant professor of geriatric psychiatry, said in the Duke news release.

"For this reason, researchers should focus not only on people at risk because of the APOE gene, but also those who have a family history of Alzheimer's disease. Conversely, studying those who survive to late old age without disease is important to discover genes that may offer protection against the disease."

The study was expected to be presented Tuesday at the Alzheimer's Association's International Conference on Alzheimer's Disease, in Chicago.

"These data provide further evidence that we must explore other genetic avenues to learn more about who is at risk for cognitive decline and dementia," Welsh-Bohmer said.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Duke University, news release, July 29, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Elekta Family of Companies to Highlight Cancer Treatment Solutions at 2008 AAPM Annual Meeting
2. Almost Family, Inc. to Report Second Quarter 2008 Financial Results
3. Ceridian LifeWorks Offers CareGiverHelper Service to Clients to Ease Stress of Family Caregiving
4. Almost Family Secures $75 Million Revolving Credit Facility
5. Family resources, parenting quality influence childrens early cognitive development
6. July/August 2008 Annals of Family Medicine tip sheet
7. Life Record Inc. Announces EmergenKey, My Life Record Family and Personal Edition for the iPhone on the Apple App Store
8. Chindexs United Family Healthcare Launches ChinaHealthWatch.org - A global resource for travelers to China
9. Autism and the Family is the Topic for July 11th Conference in Washington, DC
10. Dog Days of Summer Festival Brings Pet Adoptions, Dog-Centric Family Fun Back to Hermon Park
11. New Giant Pharmacy Program Offers Relief for Your Family and Your Wallet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2017)... Chicago, IL (PRWEB) , ... July 28, 2017 , ... ... services to families and business owners in and around Cook County, is working in ... raise support for students and veterans. , Established in honor of a brave soldier ...
(Date:7/27/2017)... , ... July 27, 2017 , ... Georgia Urology ... Dr. Brent Sharpe who is now serving urology patients in the Braselton ... 203 in Flowery Branch, and is open on Mondays, Tuesdays, Wednesdays, and Fridays. The ...
(Date:7/27/2017)... , ... July 27, 2017 , ... Standard Process is ... Center of Excellence at the North Carolina Research Campus (NCRC) in Kannapolis, North Carolina ... center will open in the fall of this year, occupying over 10,000 square feet ...
(Date:7/27/2017)... ... , ... TransPanel Volume 4 is a collection of animating panel transitions made ... transitions that contain between 2 and 6 animated panels. Change the direction of panels ... Volume 4 makes editing easy in Final Cut Pro X. , TransPanel Volume 4 ...
(Date:7/27/2017)... OH (PRWEB) , ... July 27, 2017 , ... ... Electronic Visit Verification to State Medicaid programs, Managed Care Organizations and Home Care ... 2017. , The MEDsys platform, VinCENT, provides technology solutions to over 1,000 agencies ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... , July 26, 2017 The Galien Foundation ... Galien USA Award Nominees. Counted among ... Galien Award recognizes outstanding biomedical and technology product achievement that ... To qualify, each candidate must be U.S. Food and ... years and demonstrate tremendous potential to impact human health. Sales ...
(Date:7/21/2017)... N.Y. and EDMONTON, Alberta ... IBM ) scientists and the University of Alberta ... published new data in Nature,s partner journal, Schizophrenia ... algorithms helped predict instances of schizophrenia with 74% ... predicted the severity of specific symptoms in schizophrenia ...
(Date:7/19/2017)...  Mako Medical Laboratories partnered with Secretary Strickland, the ... Fund (MFA) to bring 140 soldiers back home to ... families one last time before being deployed. Mako Medical ... logistics needed for these soldiers. "Mako Medical Laboratories is ... We just wish we could bring them all home," ...
Breaking Medicine Technology: