Navigation Links
Familial MS May Be More Destructive

Brain scans reveal more damage compared to sporadic cases

FRIDAY, Oct. 12 (HealthDay News) -- Multiple sclerosis that runs in families appears to cause more severe brain damage than the non-familial form, say University at Buffalo researchers.

They used MRI scans to examine the brains of 759 MS patients and found that the 198 patients with familial MS had significantly more destructed lesions, and significantly lower volume of whole brain, white matter and gray matter, as well as other indications of greater brain damage.

"Patients whose parents, children or siblings (first-degree relatives) had MS showed more damage than patients who had cousins with MS. This indicates that the closer the relationship, the greater the risk of MS," research team leader Dr. Robert Zivadinov, professor of neurology, said in a prepared statement.

"Of particular interest is the finding of more severe gray matter damage and more lesions, particularly in those with MS in first-degree relatives. These findings are very interesting, and we will be investigating them further," he added.

The study was to be presented Friday at a European Committee for the Treatment and Research in Multiple Sclerosis meeting in Prague, Czech Republic.

"From the early 1980s on, MS researchers thought that genetic factors likely played a role in the disease, that its traits were determined by several different genes, and our findings support this hypothesis," Zivadinov said.

"Our MRI analysis showed a difference between the severity of disease characteristics in familial MS patients versus what we call sporadic, or non-familial, MS patients. These differences may be related to some disease-modifying genes, but to prove this, we must do further investigation," he added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about MS.

-- Robert Preidt

SOURCE: University at Buffalo, news release, Oct. 12, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tobacco Found To Trigger Familial Pancreatic Cancer
2. Familial Breast cancer without gene mutation not found to cause ovarian cancer.
3. Obsessive-Compulsive Disorder Is Familial
4. Women Testing Negative for Familial Breast Cancer Gene Still at Increased Risk
5. Team Discovers a Gene That Causes Familial Pancreatic Cancer
6. Harm to the chest can be destructive
7. Internet Encourages Self-Destructive Behaviour Among Teens
8. Genetics Plays A Crucial Role In Preemies Destructive Eye Disease
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from reveals that behind the tendency to set ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: