Navigation Links
Familial MS May Be More Destructive

Brain scans reveal more damage compared to sporadic cases

FRIDAY, Oct. 12 (HealthDay News) -- Multiple sclerosis that runs in families appears to cause more severe brain damage than the non-familial form, say University at Buffalo researchers.

They used MRI scans to examine the brains of 759 MS patients and found that the 198 patients with familial MS had significantly more destructed lesions, and significantly lower volume of whole brain, white matter and gray matter, as well as other indications of greater brain damage.

"Patients whose parents, children or siblings (first-degree relatives) had MS showed more damage than patients who had cousins with MS. This indicates that the closer the relationship, the greater the risk of MS," research team leader Dr. Robert Zivadinov, professor of neurology, said in a prepared statement.

"Of particular interest is the finding of more severe gray matter damage and more lesions, particularly in those with MS in first-degree relatives. These findings are very interesting, and we will be investigating them further," he added.

The study was to be presented Friday at a European Committee for the Treatment and Research in Multiple Sclerosis meeting in Prague, Czech Republic.

"From the early 1980s on, MS researchers thought that genetic factors likely played a role in the disease, that its traits were determined by several different genes, and our findings support this hypothesis," Zivadinov said.

"Our MRI analysis showed a difference between the severity of disease characteristics in familial MS patients versus what we call sporadic, or non-familial, MS patients. These differences may be related to some disease-modifying genes, but to prove this, we must do further investigation," he added.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about MS.

-- Robert Preidt

SOURCE: University at Buffalo, news release, Oct. 12, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tobacco Found To Trigger Familial Pancreatic Cancer
2. Familial Breast cancer without gene mutation not found to cause ovarian cancer.
3. Obsessive-Compulsive Disorder Is Familial
4. Women Testing Negative for Familial Breast Cancer Gene Still at Increased Risk
5. Team Discovers a Gene That Causes Familial Pancreatic Cancer
6. Harm to the chest can be destructive
7. Internet Encourages Self-Destructive Behaviour Among Teens
8. Genetics Plays A Crucial Role In Preemies Destructive Eye Disease
Post Your Comments:
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , the ... chains, has published the first annual edition of its Global CSR Risk ... 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly ... ... Performance Index ...
Breaking Medicine Technology: